Heterocyclic Building Block-benzofuran

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase was written by Bagal, Sharan K.;Gregson, Clare;O Donovan, Daniel H.;Pike, Kurt G.;Bloecher, Andrew;Barton, Peter;Borodovsky, Alexandra;Code, Erin;Fillery, Shaun M.;Hsu, Jessie Hao-Ru;Kawatkar, Sameer P.;Li, Chengzhi;Longmire, David;Nai, Youfeng;Nash, Samuel C.;Pike, Andrew;Robinson, James;Read, Jon A.;Rawlins, Phillip B.;Shen, Minhui;Tang, Jia;Wang, Peng;Woods, Haley;Williamson, Beth. And the article was included in Journal of Medicinal Chemistry in 2021.Product Details of 2135600-87-0 This article mentions the following:

In this paper the discovery of potent and orally bioavailable EED ligands with good solubilities was disclosed. The solubility of the EED ligands was optimized through a variety of design tactics, with the resulting compounds exhibiting in vivo efficacy in EZH2-driven tumors. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride (cas: 2135600-87-0Product Details of 2135600-87-0).

(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride (cas: 2135600-87-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 2135600-87-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid characterization of the chemical constituents of Sijunzi decoction by UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry was written by Guan, Zhibo;Wang, Miao;Cai, Yi;Yang, Hongmei;Zhao, Min;Zhao, Chunjie. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2018.Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

Sijunzi decoction, a renowned Chinese prescription drug, has long been utilized to treat gastrointestinal problems. Ultra-HPLC combined with Fourier transform ion cyclotron resonance MS was used to sep. and characterize the components of Sijunzi decoction. The UHPLC was carried out on a C8 column (150 × 2.1 mm, 1.8 μm); the mobile phase consisted of 0.2% formic acid (A) and acetonitrile (B). Characterization of 120 chem. compounds was performed by UHPLC-MS. The key constituents among them included ginsenosides (in Radix Ginseng), 16 triterpene carboxylic acids (in Poria), sesquiterpenes (in Rhizoma Atractylodis Macrocephalae), triterpene saponins (in Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle) as well as flavonoids (in Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle) in Sijunzi decoction. This research developed the bases for prospective research associated with Sijunzi decoction, together with being expected to be useful to rapidly extract and characterize the constituents in other Traditional Chinese herbal formulations. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Quality Control of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemosystematic and evolutionary trends of the genistoid clade sensu stricto (Papilionoideae, Fabaceae) was written by Feitoza, Rodrigo B. B.;Lima, Helena R. P.. And the article was included in Phytochemistry (Elsevier) in 2021.Recommanded Product: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

The Papilionoideae, which comprises 503 genera and approx. 14,000 species, is the largest and most diverse subfamily of the Fabaceae family. In this subfamily, the Crotalarieae, Genisteae, Podalyrieae, Thermopsideae, Sophoreae and Euchresteae tribes are closely related by micro and macromol. features, thus forming the genistoid clade. This group combines well-known genera, whereas other genera lack phytochem. and chemotaxonomic studies. Thus, this work aimed to characterize the special metabolites in these genera in order to define the chem. profile, the micromol. markers and the chem. diversity, as well as to evaluate the group evolutionary trends. Flavonoids and alkaloids were identified as chemosystematic markers for the studied tribes due to high occurrence number and structural diversity. Among flavonoids, the flavones and isoflavones predominated. Low protection indexes of flavonoid hydroxyls by O-glycosylation or O-methylation were observed, whereas C-prenylation and C-glycosylation were frequent, mainly at C-6 and C-8 positions. The flavone/flavonol ratio shows the predominance of the flavones. Quinolizidine and piperidine alkaloids were present in most genera. Pyrrolizidine alkaloids were found in a few genera from Thermopsideae, Genisteae and Crotalarieae, which suggests a mechanism of adaptive convergence. Cluster anal. allowed separation of genera for each tribe by chem. similarities. The micromol. trends of protection of flavonoid hydroxyls and alkaloid oxidation indicate the genistoid clade is through evolutionary transition, which is consistent with its phylogenetic position in the Papilionoideae subfamily. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Recommanded Product: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A comparison of nitrophenyl esters and lactones as substrates of cytosolic aldehyde dehydrogenase was written by Kitson, Trevor M.;Kitson, Kathryn E.. And the article was included in Biochemical Journal in 1996.Recommanded Product: 21997-23-9 This article mentions the following:

P-Nitrophenyl (PNP) acetate and propionate show a burst of p-nitrophenoxide release when their hydrolysis is catalyzed by sheep liver cytosolic aldehyde dehydrogenase. This is not seen in the presence of NAD⁺ or NADH, implying a change in rate-determining step. 6-Nitrodihydrocoumarin (6-NDC) shows no burst of absorbance in the visible region. We propose that the pK_a of the transient reporter group produced during the hydrolysis of this lactone is high (approx. 10) and that the incipient covalently linked p-nitrophenoxide moiety is protonated immediately on formation. The small burst seen in the hydrolysis of 5-nitro-2-coumaranone (5-NC) suggests that the pK_a of its reporter group is about 8.5. NADH markedly enhances the steady-state rate with the lactones. 5-NC shows a large rapid burst of color development in the presence of NADH; this implies that NADH decreases the pK_a of the reporter group to 7-7.5. In the presence of NAD^–, 5-NC and 6-NDC give an unusual neg. burst in the stopped-flow traces. We propose that, under these circumstances, acylation of the enzyme is extremely fast and that the first event seen in the stopped-flow traces is protonation of the reporter group. NAD⁺ also greatly increases the steady-state rate. With the lactones in the presence of NADH, the k_cat value (nearly 6 s^-1), a measure of the deacylation rate, is compatible with the single-site model for dehydrogenase and esterase activities. In the experiment, the researchers used many compounds, for example, 5-Nitrobenzofuran-2(3H)-one (cas: 21997-23-9Recommanded Product: 21997-23-9).

5-Nitrobenzofuran-2(3H)-one (cas: 21997-23-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 21997-23-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ultrasound-triggered herceptin liposomes for breast cancer therapy was written by Elamir, Amal;Ajith, Saniha;Sawaftah, Nour Al;Abuwatfa, Waad;Mukhopadhyay, Debasmita;Paul, Vinod;Al-Sayah, Mohammad H.;Awad, Nahid;Husseini, Ghaleb A.. And the article was included in Scientific Reports in 2021.Recommanded Product: 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid This article mentions the following:

The functionalization of liposomes with monoclonal antibodies is a potential strategy to increase the specificity of liposomes and reduce the side-effects associated with chemotherapeutic agents. The active targeting of the Human Epidermal growth factor Receptor 2 (HER2), which is overexpressed in HER2 pos. breast cancer cells, can be achieved by coating liposomes with an anti-HER2 monoclonal antibody. In this study, we synthesized calcein and Doxorubicin-loaded immunoliposomes functionalized with the monoclonal antibody Trastuzumab (TRA). Both liposomes were characterized for their size, phospholipid content and antibody conjugation. Exposing the liposomes to low-frequency ultrasound (LFUS) triggered drug release which increased with the increase in power d. Trastuzumab conjugation resulted in enhancing the sensitivity of the liposomes to LFUS. Compared to the control liposomes, TRA-liposomes showed higher cellular toxicity and higher drug uptake by the HER2 + cell line (SKBR3) which was further improved following sonication with LFUS. Combining immunoliposomes with LFUS is a promising technique in the field of targeted drug delivery that can enhance efficiency and reduce the cytotoxicity of antineoplastic drugs. In the experiment, the researchers used many compounds, for example, 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0Recommanded Product: 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid).

2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Recommanded Product: 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and aldose reductase-inhibitory activity of benzo[b]furan derivatives possessing a carboxymethylsulfamoyl group was written by Ohishi, Yoshitaka;Mukai, Teruo;Nagahara, Michiko;Yajima, Motoyuki;Kajikawa, Norio. And the article was included in Chemical & Pharmaceutical Bulletin in 1989.Category: benzofurans This article mentions the following:

Various benzo[b]furan derivatives with a carboxymethylsulfamoyl group e.g. I [R = (CH₂)_nMe, CH₂C₆H₄NO₂-4, CH₂COMe, CH₂CO₂H; n = 0-6], were prepared and evaluated for aldose reductase-inhibitory potency. Most of the compounds displayed significant inhibitory activities (IC₅₀, 10^-8-10^-7 M). Among the test compounds, the compounds having a carboxymethylsulfamoyl group at the 3- or 4-position exhibited the greatest inhibitory potency. Structure-activity trends of the tested compounds are discussed. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8Category: benzofurans).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Combustion of furniture wood waste and solid wood: Kinetic study and evolution of pollutants was written by Moreno, Ana Isabel;Font, Rafael;Conesa, Juan A.. And the article was included in Fuel in 2017.SDS of cas: 205-39-0 This article mentions the following:

This work is focused on the combustion processes of wood waste. Two kinds of waste have been studied: furniture wood waste (treated and used wood) and solid wood from factories (untreated wood). A kinetic study has been carried out for each material in air and an N₂:O₂ 9:1 atm with dynamic and dynamic + isothermal runs at different heating rates, considering the decomposition of the three main components of the wood and also the combustion of the char obtained. Satisfactory kinetic models were obtained for each kind of wood. Significant differences in thermal behavior were found between furniture wood waste and solid wood, probably due to the presence of additives and inorganic compounds in the furniture wood waste, which modifies the kinetic parameters of the thermal process. Moreover, combustion runs at 850 °C of both kinds of woods were also carried out in a laboratory scale tubular reactor in order to analyze the volatile and semivolatile compounds The main differences were found in the higher yield of nitrogenated compounds found during the combustion of the furniture wood waste. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0SDS of cas: 205-39-0).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 205-39-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Palladium(0)-Catalyzed Dearomatization of 2-Nitrobenzofurans through Formal (3+2) Cycloadditions with Vinylcyclopropanes: A Straightforward Access to Cyclopenta[b]benzofurans was written by Ling, Johanne;Laugeois, Maxime;Michelet, Veronique;Ratovelomanana-Vidal, Virginie;Vitale, Maxime R.. And the article was included in Synlett in 2018.Product Details of 33094-66-5 This article mentions the following:

The design and synthesis of a series of novel cyclopenta[b]benzofuran derivatives e.g., I via palladium-catalyzed dearomatization of various 2-nitrobenzofurans such as 2-nitrobenzofuran, 5-chloro-2-nitrobenzofuran, 7-methoxy-2-nitrobenzofuran, etc. efficiently undergo a dearomative (3+2) cycloaddition with vinylcyclopropanes such as 2-vinylcyclopropane-1,1-dicarbonitrile, diisopropyl 2-vinylcyclopropane-1,1-dicarboxylate, 5,7-dimethyl-1-vinyl-5,7-diaza-spiro[2.5]octane-4,6,8-trione, etc. has been reported. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Product Details of 33094-66-5).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 33094-66-5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Use of dielectrophoresis for directing T cells to microwells before nanostraw transfection: modelling and experiments was written by Lard, Mercy;Ho, Bao D.;Beech, Jason P.;Tegenfeldt, Jonas O.;Prinz, Christelle N.. And the article was included in RSC Advances in 2022.Application of 1461-15-0 This article mentions the following:

Nanostraw substrates have great potential for achieving minimally invasive cell transfection. Cells located on the nanostraw substrate are subjected to mild DC elec. pulses applied across the nanostraw substrate, which open pores in the cell membrane on top of the nanostraws and drives charged cargo through these pores via electrophoresis. However, with this method, the current may leak through uncovered nanostraws, thereby decreasing the desired effect in the cell-covered nanostraws. A minimization of the number of uncovered nanostraws could be achieved by high cell coverage, but this is challenging when working with small cell populations. Nanostraw substrates of smaller area could be covered by smaller cell populations but are hard to integrate into fluidics systems. Here, we use simulations and experiments to show that this issue can be addressed by covering the nanostraw substrate with an insulating layer containing pores of similar size to cells. The pores act as traps into which cells can be guided using dielectrophoresis, ensuring a high degree of occupancy while maintaining a high cell viability, even if the total number of cells is low. In the experiment, the researchers used many compounds, for example, 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0Application of 1461-15-0).

2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 1461-15-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ti(IV) doping: An effective strategy to boost Lewis acidic performance of ZnO catalyst in fluorescein dye synthesis was written by Jadhav, Nirajkumar H.;Shinde, Dnyaneshwar R.;Sakate, Sachin S.;Rasal, Nishant K.;Pawar, Ramdas A.. And the article was included in Catalysis Communications in 2019.Application of 36886-76-7 This article mentions the following:

Zn_1-xTi_xO NPs were efficiently synthesized using a simple solution free mechanochem. method. The synthesized ZnO and Ti(IV)-doped ZnO catalysts are exhibited polycrystallinity, a hexagonal crystal structure, and roughly spherical agglomerates. The surface areas of the Zn_1-xTi_xO catalysts were pos. correlated with the doping percentage of Ti(IV), which also enhanced the Lewis acidity of the NPs. The catalysts exhibited excellent activity during the synthesis of fluorescein dyes. This methodol. was also extended to sulfone-fluorescein dye synthesis. In the experiment, the researchers used many compounds, for example, 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7Application of 36886-76-7).

3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application of 36886-76-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem