Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase was written by Bagal, Sharan K.;Gregson, Clare;O Donovan, Daniel H.;Pike, Kurt G.;Bloecher, Andrew;Barton, Peter;Borodovsky, Alexandra;Code, Erin;Fillery, Shaun M.;Hsu, Jessie Hao-Ru;Kawatkar, Sameer P.;Li, Chengzhi;Longmire, David;Nai, Youfeng;Nash, Samuel C.;Pike, Andrew;Robinson, James;Read, Jon A.;Rawlins, Phillip B.;Shen, Minhui;Tang, Jia;Wang, Peng;Woods, Haley;Williamson, Beth. And the article was included in Journal of Medicinal Chemistry in 2021.Product Details of 2135600-87-0 This article mentions the following:
In this paper the discovery of potent and orally bioavailable EED ligands with good solubilities was disclosed. The solubility of the EED ligands was optimized through a variety of design tactics, with the resulting compounds exhibiting in vivo efficacy in EZH2-driven tumors. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride (cas: 2135600-87-0Product Details of 2135600-87-0).
(5-Fluoro-2,3-dihydrobenzofuran-4-yl)methanamine hydrochloride (cas: 2135600-87-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 2135600-87-0
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem