Tag: M.W:200-300

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, molecular formula is C11H11NO3. In an article, author is Jang, Hyo Jung,once mentioned of 174775-48-5, Category: benzofurans.

Colorimetric Detection of Co2+, Cu2+, and Zn2+ by a Multifunctional Chemosensor in Aqueous Solution

A novel multifunctional colorimetric sensor HMBC ((E)-3-((2-hydroxy-3-methoxybenzylidene)amino)benzofuran-2-carboxamide), based on 3-aminobenzofuran-2-carboxamide and 2-hydroxyl-3-methoxylbenzaldehyde, was designed and synthesized. The chemosensor HMBC could sense Co2+, Cu2+, and Zn2+ by color changes from colorless to yellow. Limits of detection (0.38, 0.41, and 1.02 mu M) of HMBC for Co2+, Cu2+, and Zn2+ were much lower than the New Jersey Department of Environmental Protection (NJDEP) standard (1.70 mu M) for Co2+ and the WHO guidelines (31.5 mu M and 76 mu M) for Cu2+ and Zn2+. Significantly, HMBC could be applied for the quantification of Co2+, Cu2+, and Zn2+ in real samples. The sensing process of HMBC for Co2+, Cu2+, and Zn2+ was well demonstrated by H-1 NMR and UV-Visible titrations, Job plots, theoretical calculations, and ESI-mass spectroscopy.

Interested yet? Keep reading other articles of 174775-48-5, you can contact me at any time and look forward to more communication. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: C10H7NO4, 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a document, author is Maeno, Zen, introduce the new discover.

Efficient Synthesis of Benzofurans via Cross-Coupling of Catechols with Hydroxycoumarins Using O-2 as an Oxidant Catalyzed by AlPO4-Supported Rh Nanoparticle

An efficient synthesis of benzofuran derivatives via the cross-coupling of catechols and hydroxycoumarins in H2O using O-2 as an ideal oxidant is reported. The above reaction allows the direct use of substrates without prefunctionalization, involves formation of C-C and C-O bonds in cascade manner, and affords H2O as the sole by-product. This simple and clean reaction is achieved by the development of an AlPO4-supported Rh nanoparticle catalyst. The catalyst was applicable to the synthesis of a wide range of benzofurans. We also successfully utilized this catalytic method for total synthesis of flemichapparin C, one of the naturally occurring coumestans exhibiting bioactivity. The combined functions of Rh nanoparticles and AlPO4 play a key role in this reaction where in situ generated o-benzoquinone by Rh nanoparticles is possibly an intermediate for nucleophilic addition to hydroxycoumarins on AlPO4.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3. HPLC of Formula: C10H7NO4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, SMILES is O=C(C1=CC2=CC(N)=CC=C2O1)OCC, in an article , author is Zhao, Chao, once mentioned of 174775-48-5, Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate.

Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A

Protein kinases play an indispensable role in signaling pathways that regulate tumor cell functions, which represent potent therapeutic targets in cancers. Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) as a serine/threonine kinase has recently been reported to be upregulated in pancreatic ductal adenocarcinoma (PDAC) and show protumorigenic effect. By activity-guided phytochemical investigation of the extracts from Glycyrrhiza uralensis Fisch, we expect to find the effective constituents that can suppress pancreatic cancer cell proliferation and/or induce cells apoptotic by inhibiting DYRK1A. Eight isopentenyl-substituted compounds (1-8), including four coumarins (1-4), one benzofuran (5), and three flavonoids (6-8), were isolated and identified from G. uralensis Fisch. Among them, licocoumarone (LC, 5) showed effective inhibitory activity against DYRK1A with an IC50 value of 12.56 mu M. Molecular docking analysis suggested that LC completely occupied the whole pocket of DYRK1A and formed obvious hydrophobic interactions and hydrogen bonds with DYRK1A residues. Further in vitro validation, including Microscale Thermophoresis (MST) and drug affinity responsive target stability (DARTS) techniques, demonstrated the specific combining capacity of LC to DYRK1A. Meanwhile, LC induced significant cytotoxicity against DYRK1A-overexpressing BxPC-3 cells with an IC50 value of 50.77 mu M. Mechanism studies revealed that LC reduced c-MET protein level by inhibiting DYRK1A. These findings provide preliminary evidences that LC as a natural DYRK1A inhibitor suppresses human pancreatic adenocarcinoma BxPC-3 cell proliferation and induces cell apoptotic, which might present new options and possibilities for targeted therapies in pancreatic cancer therapy.

Interested yet? Read on for other articles about 174775-48-5, you can contact me at any time and look forward to more communication. Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Meyer-Alert, Henriette, once mentioned the application of 6296-53-3, Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, molecular weight is 205.1669, MDL number is MFCD00453138, category is benzofurans. Now introduce a scientific discovery about this category.

Benzo[a]pyrene and 2,3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio)

Biotests like the fish embryo toxicity test have become increasingly popular in risk assessment and evaluation of chemicals found in the environment. The large range of possible endpoints is a big advantage when researching on the mode of action of a certain substance. Here, we utilized the frequently used model organism zebrafish (Danio rerio) to examine regulative mechanisms in the pathway of the aryl-hydrocarbon receptor (AHR) in early development. We exposed embryos to representatives of two chemical classes known to elicit dioxin-like activity: benzo[a]pyrene for polycyclic aromatic hydrocarbons (PAHs) and 2,3-benzofuran for polar O-substituted heterocycles as a member of heterocyclic compounds in general (N-, S-, O-heterocycles; NSO-hets). We measured gene transcription of the induced P450 cytochromes (cyp1), their formation of protein and biotransformation activity throughout the whole embryonic development until 5 days after fertilization. The results show a very specific time course of transcription depending on the chemical properties (e.g. halogenation, planarity, K-ow), the physical decay and the biodegradability of the tested compound. However, although this temporal pattern was not precisely transferable onto the protein level, significant regulation in enzymatic activity over time could be detected. We conclude, that a careful choice of time and end point as well as consideration of the chemical properties of a substance are fairly important when planning, conducting and especially evaluating biotests.

If you are interested in 6296-53-3, you can contact me at any time and look forward to more communication. Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of Ethyl 5-aminobenzofuran-2-carboxylate, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, molecular formula is C11H11NO3. In an article, author is Sun, Zhi-Gang,once mentioned of 174775-48-5.

The Research Progress of Direct Thrombin Inhibitors

Blood coagulation is the process of changing the blood from the flowing state to the gel state. It is an important part of the hemostatic function. Coagulation is a process by which a series of coagulation factors are sequentially activated, and finally thrombin is formed to form fibrin clot. Direct thrombin inhibitors are important anticoagulant drug. These drugs can selectively bind to the active site of thrombin, inhibit thrombin activity, have strong action and high specificity, and have important significance in the clinical treatment of thrombus diseases. Some of them come from natural products of animals or plants, and many of them have been applied in the clinic. The other part is derived from the design, synthesis and activity studies of small molecule inhibitors. This review discusses the progress of direct thrombin inhibitors in recent years.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem