Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: C10H7NO4, 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a document, author is Maeno, Zen, introduce the new discover.
Efficient Synthesis of Benzofurans via Cross-Coupling of Catechols with Hydroxycoumarins Using O-2 as an Oxidant Catalyzed by AlPO4-Supported Rh Nanoparticle
An efficient synthesis of benzofuran derivatives via the cross-coupling of catechols and hydroxycoumarins in H2O using O-2 as an ideal oxidant is reported. The above reaction allows the direct use of substrates without prefunctionalization, involves formation of C-C and C-O bonds in cascade manner, and affords H2O as the sole by-product. This simple and clean reaction is achieved by the development of an AlPO4-supported Rh nanoparticle catalyst. The catalyst was applicable to the synthesis of a wide range of benzofurans. We also successfully utilized this catalytic method for total synthesis of flemichapparin C, one of the naturally occurring coumestans exhibiting bioactivity. The combined functions of Rh nanoparticles and AlPO4 play a key role in this reaction where in situ generated o-benzoquinone by Rh nanoparticles is possibly an intermediate for nucleophilic addition to hydroxycoumarins on AlPO4.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3. HPLC of Formula: C10H7NO4.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem