Tag: M.W:200-300

Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 652-12-0, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 652-12-0

The introduction of fluorine into bioactive molecules is a matter of importance in medicinal chemistry. In this study, representatives of various chemical entities of fluoroaromatic compounds were synthesized. Depending on the reaction conditions, either tetrafluorophthalimides or ammonium tetrafluorophthalamates are accessible from tetrafluorophthalic anhydride and primary amines. Tetrafluorophthalamic acids undergo thermal decarboxylation to yield tetrafluorobenzamides. These could be successfully converted upon treatment with primary amines, in the course of an aromatic nucleophilic substitution, to 2,3,5-trifluorobenzamides with respective amino substituents at the 4-position. The five structure types were characterized by means of spectroscopic and crystallographic methods. The synthesized compounds were evaluated as inhibitors of angiogenesis by measuring microvessel outgrowth in a rat aortic ring assay. The biological activity was maintained throughout these different polyfluorinated chemotypes.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3766O – PubChem

Reference of 763114-25-6, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 763114-25-6, 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile, introducing its new discovery.

An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4010O – PubChem

Application of 127264-14-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran, molecular formula is C10H11BrO. In a Patent，once mentioned of 127264-14-6

Amines of the following formula: STR1 where the variables are defined in the specification are useful in the treatment of diseases associated with altered motility and/or tone of smooth muscle.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 127264-14-6. In my other articles, you can also check out more blogs about 127264-14-6

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3805O – PubChem

Electric Literature of 652-12-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 652-12-0, Name is Tetrafluorophthalic anhydride, molecular formula is C8F4O3. In a Article，once mentioned of 652-12-0

A specific example of a Sequestration Enabling Reagent (SER), tetrafluorophthalic anhydride, is used in the purification of solution-phase reactions involving amines with electrophiles. The SER is added to an incomplete reaction mixture containing product, amine, and electrophile. The SER covalently reacts with remaining amine, affording a derivatized amine with an artificially-imparted acid tag. This ‘tagged’ amine is now sequesterable by the same CMR/R polyamine resin used to sequester the electrophile and both are easily removed from the reaction mixture affording pure product.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 652-12-0. In my other articles, you can also check out more blogs about 652-12-0

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3751O – PubChem

Synthetic Route of 127264-14-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran,introducing its new discovery.

The invention relates to a darifenacin intermediate – 2, 3 – dihydro – 5 – benzofuran acetic acid. By the P-hydroxy-acetic acid and bromo acetaldehyde acetal as the starting material, the presence of O – alkylation reaction under a condition of the corresponding ether compound; then by esterification reaction to obtain the corresponding ester; in PPA (poly phosphoric acid) under the action of the, cyclization to obtain 2, 3 – benzofuran – 5 – acetate; 2, 3 – benzofuran – 5 – acetic acid layer which hydrolysis, to acidify the corresponding carboxylic acid; obtained by catalytic hydrogenation of 2, 3 – dihydro – 5 – benzofuran acetic acid; or the first 2, 3 – benzofuran – 5 – acetate obtained by catalytic hydrogenation of 2, 3 – dihydro – 5 – benzofuran acetic acid esters; and hydrolyzed, acidified to obtain 2, 3 – dihydro – 5 – benzofuran acetic acid. The method of the invention by simple and safe, each reaction raw materials are cheap and easy to obtain, the reaction yield is high, and is particularly suitable for industrial production of 2, 3 – dihydro – 5 – benzofuran acetic acid. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3825O – PubChem

Synthetic Route of 10242-12-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid, introducing its new discovery.

The invention provides a 3 – (2 – phenylethyl and five-membered heterocyclic) – 4 – (3 – dimethylamine c amino) quinoline derivatives and its preparation method and application, 3 – (2 – phenylethyl and five-membered heterocyclic) – 4 – (3 – dimethylamine c amino) quinoline derivatives of the formula is: . The compound has a good anti-tumor activity, can be applied to the preparation of anti-tumor drug. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3518O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of Ethyl (5-bromobenzofuran)-2-carboxylate, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 84102-69-2, name is Ethyl (5-bromobenzofuran)-2-carboxylate. In an article，Which mentioned a new discovery about 84102-69-2

A superior method for the synthesis of substituted ethyl benzofuran-2-carboxylates in 80-99% yields from substituted 2-formylphenoxy ethylcarboxylates using 0.4 equiv of commercially available P(MeNCH2CH2)3N at 70 C for 3 hours is described.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4044O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 143878-29-9, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 143878-29-9

High acid crudes contain large amounts of naphthenic acids (NAs), which lead to severe corrosion in oil refinery equipment and serious environmental problems. The goal of this study is to develop a non-catalytic supercritical methanol (scMeOH) route for effective deacidification of NA mixtures and high acid crudes (Laguna and Bachaquero-13). Various reaction parameters, including temperature, pressure, reaction time, and NA-to-methanol ratio, are explored to find effective reaction conditions for reducing the total acid number (TAN) of the mixtures. Almost complete TAN reduction of naphthenic acid (96.9%) is achieved at 400 C, 10 MPa, and 3 h. The reaction in scMeOH at 400 C, 30 MPa and 1 h is effective in the TAN reaction of high acid crudes (93.6-94.0%). The chemical composition of the liquid products obtained under the different reaction conditions, analyzed using gas chromatography-mass spectroscopy, show that esters are the most abundant species, indicating that esterification with scMeOH is the major reaction pathway. The most recalcitrant NA species, which remained after the reaction, are found to be 2-ethyl-2,3,3-trimethyl-butanoic acid and 2,3-dimethyl-2-(1-methylethyl)-butanoic acid. This is attributed to the branched hydrocarbons located near the carboxylic acid groups, which hinder the access of methanol molecules.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4089O – PubChem

Application of 652-12-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.652-12-0, Name is Tetrafluorophthalic anhydride, molecular formula is C8F4O3. In a Article，once mentioned of 652-12-0

In this paper we report the design, synthesis and pharmacological evaluation of a new series of phenyl sulfonamide derivatives 2a-h and 3-8 planned by structural modification on the anti-inflammatory prototype LASSBio-468 (1). Among the synthesized analogues, the tetrafluorophthalimide LASSBio-1439 (2e) stands out showing an in vitro anti-TNF-a effect similar to the standard thalidomide. The relevance of tetrafluorination of the phthalimide nucleus was also confirmed by the anti-inflammatory profile of 2e, through oral administration, in a murine model of pulmonary inflammation. The corresponding tetrafluorocarboxyamide metabolite LASSBio-1454 (15), generated from partial hydrolysis of the derivative 2e, presented a significant in vitro effect and a pronounced anti-inflammatory activity in vivo.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3717O – PubChem

Electric Literature of 501892-90-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.501892-90-6, Name is Methyl 3-bromobenzofuran-5-carboxylate, molecular formula is C10H7BrO3. In a Review，once mentioned of 501892-90-6

Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and chemotherapy have long been the first choices for cancer patients. However, the prognosis of CRC has never been satisfying, especially for patients with metastatic lesions. Targeted therapy is a new optional approach that has successfully prolonged overall survival for CRC patients. Following successes with the anti-EGFR (epidermal growth factor receptor) agent cetuximab and the anti-angiogenesis agent bevacizumab, new agents blocking different critical pathways as well as immune checkpoints are emerging at an unprecedented rate. Guidelines worldwide are currently updating the recommended targeted drugs on the basis of the increasing number of high-quality clinical trials. This review provides an overview of existing CRC-targeted agents and their underlying mechanisms, as well as a discussion of their limitations and future trends.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3984O – PubChem