Tag: M.W:100-200

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4265-16-1, name is Benzo[b]furan-2-carboxaldehyde, introducing its new discovery. COA of Formula: C9H6O2

A novel palladium-catalyzed selective hydroxylfluorination of gem-difluoroalkenes has been developed. By employing easily obtainable gem-difluoroalkenes and NFSI as the fluorine source, the scope, advantages, and limitations of this reaction were investigated. The reaction presents an efficient synthesis to afford a series of alpha-trifluoromethyl alcohols in good to excellent yields. Furthermore, this reaction probably proceeds via oxidation of Pd0 to PdII fluoride complex by NFSI, followed by fluoropalladation of gem-difluoroalkenes to generate an alpha-trifluoromethylbenzyl?Pd intermediate. And this strategy offers more possibilities for the construction of other bonds, such as C?C, C?N and C?S.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1128O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. name: 2,3-Dihydrobenzofuran-2-carboxylic acid, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1914-60-9

The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer’s disease, Parkinson’s disease and the like.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2167O – PubChem

Reference of 41717-32-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 41717-32-2, Name is 1-Benzofuran-2-carbonitrile,introducing its new discovery.

The tandem reaction is a growing field to yield important advances toward green and sustainable chemistry. Herein, we report a bifunctional manganese oxide catalyst with an interface binding redox phase (alpha-MnO2) and a basic phase (NaxMnO2). The molar ratio of NaOH/Mn plays a great role in the formation of alpha-MnO2/NaxMnO2. The sodium cation is essential for the formation of a basic NaxMnO2 phase while the potassium cation promotes the formation of a redox-active alpha-MnO2 phase. The interface structure of alpha-MnO2/NaxMnO2 geometrically favors the ammoxidation-Pinner tandem reaction to synthesize imidates in a 58-96% yield from aldehydes. Thus a phase collaborative effect is observed. In the ammoxidation process, the redox cycle of MnIV/MnIII is involved and the lattice oxygen in the alpha-MnO2 phase acts as an active oxygen species. The O-H in methanol is activated and dissociated on the basic sites of NaxMnO2 to the adsorbed methoxyl species to facilitate the Pinner synthesis. This approach bypasses the conventional synthesis of imidates, which suffer from harsh reaction conditions and the requirement for multiple steps.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H615O – PubChem

Reference of 496-41-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Article，once mentioned of 496-41-3

In this study, a successful medicinal chemistry campaign that exploited virtual, biophysical, and biological investigations led to the identification of a novel class of IDO1 inhibitors based on a benzimidazole substructure. This family of compounds is endowed with an extensive bonding network in the protein active site, including the interaction with pocket C, a region not commonly exploited by previously reported IDO1 inhibitors. The tight packing of selected compounds within the enzyme contributes to the strong binding interaction with IDO1, to the inhibitory potency at the low nanomolar level in several tumoral settings, and to the selectivity toward IDO1 over TDO and CYPs. Notably, a significant reduction of L-Kyn levels in plasma, together with a potent effect on abrogating immunosuppressive properties of MDSC-like cells isolated from patients affected by pancreatic ductal adenocarcinoma, was observed, pointing to this class of molecules as a valuable template for boosting the antitumor immune system.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1957O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 41717-32-2, name is 1-Benzofuran-2-carbonitrile, introducing its new discovery. category: benzofuran

An iridium-catalyzed hydrogen transfer has been developed in the presence of p-benzoquinone, allowing the synthesis of a diversity of substituted benzofurans, benzothiophenes, and indoles from substituted benzylic alcohols.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H591O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 2,3-Dihydrobenzofuran-5-amine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 42933-43-7, Name is 2,3-Dihydrobenzofuran-5-amine, molecular formula is C8H9NO

Benzo[b]perhydroheterocyclic arylamine compounds have shown to be particularly useful as stabilizers. The compounds may serve as antioxidants, antiozoants, heat stabilizers and ultraviolet light stabilizers and such compounds are oil soluble, thus particularly suited for use as an antioxidant in a lubricating oil composition.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H494O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 5-Methoxybenzofuran-3(2H)-one, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 39581-55-0, name is 5-Methoxybenzofuran-3(2H)-one. In an article，Which mentioned a new discovery about 39581-55-0

A series of substituted racemic naphthofurans were synthesized as ‘hybrid’ molecules of the two major prototypical hallucinogenic drug classes, the phenethylamines and the tryptamines/ergolines. Although it was hypothesized that these new agents might possess high affinity for the serotonin 5-HT(2A)/(2C) receptor subtypes, unexpected affinity for muscarinic receptors was observed. The compounds initially synthesized for this study were (±)-anti- and syn-4-amino-6-methoxy-2a,3,4,5-tetrahydro-2H-naphtho[1,8- bc]furan (4a,b), respectively, and their 8-bromo derivatives 4c,d, respectively. The brominated primary mines 4c,d were assayed initially for activity in the two-lever drug discrimination (DD) paradigm in rats trained to discriminate saline from LSD tartrate (0.08 mg/kg). Also, 4c,d were evaluated for their ability to compete against agonist and antagonist radioligands at cloned human 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors. After the syn diastereomers were found to have the highest activity in these preliminary assays, the N-alkylated analogues syn-N,N-dimethyl-4-amino-6- methoxy-2a,3,4,5-tetrahydro-2H-naphtho[1,8-bc]furan (4e) and syn-N,N- dipropyl-4-amino-6-methoxy-2a,3,4,5-tetrahydro-2H-naphtho[1,8-bc]furan (4f) were prepared and assayed for their affinities at [3H]ketanserin-labeled 5- HT(2A) and [3H]-8-OH-DPAT-labeled 5-HT(1A) sites. All of the molecules tested had relatively low affinity for serotonin receptors, yet a preliminary screen indicated that compound 4d had affinity for muscarinic receptors. Thus, 4b,d,e were evaluated for their affinity at muscarinic M1-M5 receptors and also assessed for their functional characteristics at the M1 and M2 isoforms. Compound 4d had affinities of 12-33 nM at all of the muscarinic sites, with 4b,e having much lower affinity. All three compounds fully antagonized the effects of carbachol at the M1 receptor, while only 4d completely antagonized carbachol at the M2 receptor. The fact that the naphthofurans lack LSD-like activity suggests that they do not bind to the serotonin receptor in a way such that the tricyclic naphthofuran nucleus is bioisosteric with, and directly superimposable upon, the A, B, and C rings of LSD. This also implies, therefore, that the hallucinogenic phenethylamines cannot be directly superimposed on LSD in a common binding orientation for these two chemical classes, contrary to previous hypotheses.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2240O – PubChem

Synthetic Route of 4265-16-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2. In a Article，once mentioned of 4265-16-1

A 1,2-reductive dearomatization of quinolines and copper(II) acetate monohydrate/(R,R)-Ph-BPE/P(p-tolyl)3-catalyzed enantioselective hydroamination sequence was developed, affording diverse 4-amino-1,2,3,4-tetrahydroquinolines with high levels of enantioselectivity in either a stepwise or one-pot fashion. Pleasingly, internal cis-cyclic alkenes, which are challenging substrates in copper hydride-catalyzed enantioselective hydroamination reactions, were transformed efficiently under mild conditions.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1116O – PubChem

Electric Literature of 4265-16-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2. In a Article，once mentioned of 4265-16-1

In the presence of a catalytic amount of Ni(cod)2 (cod = 1,5-cyclooctadiene) and PCy3 (Cy = cyclohexyl), the cross-tetramerization of tetrafluoroethylene (TFE), ethylene, alkynes, and aldehydes leads to a variety of fluorine-containing enone derivatives. This reaction is the first example of a highly selective cross-tetramerization between four different unsaturated compounds. Stoichiometric reactions revealed that the present reaction involves partially fluorinated five- and seven-membered nickelacycles as key reaction intermediates.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H879O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C10H9NO3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 57805-85-3, Name is Methyl 3-amino-2-benzo[b]furancarboxylate, molecular formula is C10H9NO3

The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound represented by the following Formula (1) The compounds indicated by formula (1) are used to promote the growth of plants. A plant seed resulting from treating with the compound represented by formula (1) and comprising an effective quantity of the compound represented by formula (1). A composition for promoting plant growth comprising the compound represented by formula (1) and an inactive ingredient.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3073O – PubChem