Some tips on 21535-97-7

The synthetic route of 21535-97-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21535-97-7,3-Methylbenzofuran,as a common compound, the synthetic route is as follows.

Compound E-3 (16 g, 121 mmol) was dissolved in 1,4-dioxane solution (100 mL), and then add selenium dioxide (17.5g, 157mmol), then, the mixture was stirred and refluxed for 16 hours. The reaction was cooled to room temperature, and the mixture was diluted with ethyl acetate /hexane (2:1, 100 mL). After stirring for 10 min, the insoluble material was removed by filtration and washed with ethyl acetate. The combined filtrates were concentrated under reduced pressure and purified by silica gel column chromatographyThe product was obtained as a yellow solid 7.3 g, yield 41%, 21535-97-7

The synthetic route of 21535-97-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan University; Li Guobo; Wu Yong; Wang Yaoling; Liu Sha; Yu Zhujun; Yan Yuhang; Huang Mengyi; (39 pag.)CN110156820; (2019); A;,
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Benzofuran | C8H6O – PubChem

Some tips on 652-39-1

As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

652-39-1, General procedure: To a solution of compounds 2a-2h (5 mmol) in acetic anhydride (5 mL) and triethylamine (2.5 mL) was added ethyl acetoacetate (0.71 mL, 5.5 mmol) under argon. The reaction mixture was stirred at rt for 12 h and then poured into the mixture of concentrated HCl (6 g) and ice-water (6 g). After that, the reaction mixture was stirred at rt for 30 min, additional HCl (8.8 mL, 5M) was added into the mixture, and then the reaction mixture was refluxed for 2 h. After the crude product was cooled to rt, water (100 mL) was added and the reaction mixture was extracted with DCM (2 100 mL). The combined organic layers were washed with brine and then dried (Na2SO4). After removing the solvent, the residue was purified by flash column chromatography.

As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.

Reference£º
Article; Guo, Shenquan; Zhang, Niuniu; Tang, Xiangzheng; Mao, Zhifeng; Zhang, Xuejing; Yan, Ming; Xuan, Yining; Chinese Chemical Letters; vol. 30; 2; (2019); p. 406 – 408;,
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Some tips on 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

18761-31-4, 5-Nitrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Further purification by column chromatography on silica gel (eluted with ethyl acetate/heptane 3:1) yielded 3.2 g of pure 5-nitro-3-(1-piperidylcarbonyl)-2,3-dihydrobenzofuran which crystallized upon standing. Mp: 108-114 C. 5-Amino-3-(1-piperidylcarbonyl)-2,3-dihydrobenzofuran: To a solution of all of the 5-nitrobenzofuran in 90% ethanol (50 ml) kept at reflux were added small portions of Fe powder (in total 2.5 g) and concentrated HCl (in total 0.1 ml) during 10 min. The mixture was refluxed for another hour. The inorganic precipitates were filtered off and the mixture was poured onto brine and ethyl acetate (250 ml). work-up of the organic phase afforded 1 g of crystalline 5-aminobenzofuran derivative., 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

Reference£º
Patent; H. Lundbeck A/S; US5807889; (1998); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 610-93-5

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

610-93-5, 6-Nitroisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

610-93-5, 6-Nitrophthalide (10 mmol) was dissolved in ethyl acetate (100 mL) and methanol (25 mL) and hydrogenated at atmospheric pressure in the presence of 10% Pd/C (0.2 g). After 24 h the reaction mixture was filtered through a bed of celite and the filtrate was removed under reduced pressure.The residue was washed with cold ethyl acetate (20 mL) to yield 6-aminophthalide. 6-Hydroxyphthalide was synthesized by reacting a cold suspension of 6-aminophthalide (3 mmol) in 10 mL H2SO4 (50%) with a cold solution of NaNO2 (3.5 mmol in 3 mL H2O) to yield the diazonium salt. The resulting solution was added to boiling (125 C) H2SO4 (50%, 20 mL) and the reaction mixture was boiled for 5 min. The reaction was rapidly cooled in an ice bath, and subsequently extracted to diethyl ether (3×20 mL). The ether portions were combined, washed with a saturated solution of NaHCO3 (25 mL) and dried over anhydrous Na2SO4. The ether was removed under reduced pressure, leaving the brown 6-hydroxyphthalide residue. Yield 65%; m.p. 198-200 C; 1H NMR (300MHz, DMSO) delta 5.25 (s, 2H), 7.15-7.18 (m, 2H), 7.39 (d, J=9.0 Hz, 1H); ESI-MS m/z: 150.9 [M+H]+.

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Zhimin; Wu, Jiajia; Yang, Xuelian; Cai, Pei; Liu, Qiaohong; Wang, Kelvin D.G.; Kong, Lingyi; Wang, Xiaobing; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5929 – 5940;,
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Brief introduction of 54008-77-4

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

54008-77-4,54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a hot oven-dried Schlenk tube under N2 atmosphere were added Ph3Bi (0.25 mmol, 110 mg, 1.0 equiv), 2-bromobenzofuran (0.825 mmol, 163 mg, 3.3 equiv), Cs2CO3 (0.75 mmol, 244 mg, 3.0 equiv), Pd(OAc)2 (0.025 mmol, 5.6 mg, 0.1 equiv), PPh3 (0.1 mmol, 26 mg, 0.4 equiv), and NMP (3 mL) solvent. The resulting mixture was stirred in preheated oil bath at 90 C for 1 h. After the reaction is over, the mixture was cooled, quenched with dil HCl and extracted with ethyl acetate. The combined organic extract was washed with water, brine, and dried over MgSO4 and concentrated. The crude was subjected to silica gel column chromatography (230-400 mesh) using petroleum ether as the eluent to obtain the pure 2-phenylbenzofuran (2.1) as a white solid (140 mg, 96%). The product was characterized by spectroscopy and in comparison with the literature data.

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

Reference£º
Article; Rao, Maddali L.N.; Awasthi, Dheeraj K.; Talode, Jalindar B.; Tetrahedron Letters; vol. 53; 21; (2012); p. 2662 – 2666;,
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Downstream synthetic route of 23145-07-5

23145-07-5, As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: A mixture of S21-SM (19.6 g, 0.1 mol), CuCN (27.3 g, 0.3 mol) and CuT (38.3 g, 0.2mol) in DMF (200 mL) was stirred at 150 ¡ãC for 4hs. Cooled, the mixture was diluted with ethylacetate and washed with brine, dried over anhydrous sodium sulfate, filtrated and concentrated to provide a residue, which was purified by column chromatography to afford S2 1-1.

23145-07-5, As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIANG, Gui-Bai; ZHOU, Changyou; WANG, Haisheng; HUO, Xianghong; WO2015/95261; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 69999-16-2

69999-16-2 2,3-Dihydrobenzofuranyl-5-acetic acid 2737455, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.,69999-16-2

EXAMPLE 50 Preparation of 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran STR64 A solution of (2,3-dihydrobenzofuran-5-yl)acetic acid (4.9 g-see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added over 10 minutes, dropwise, to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was then added dropwise with caution followed by 10% aqueous sodium hydroxide (1.5 ml) and, finally, water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate (2*50 ml). The filtrate and washings were combined and concentrated in vacuo to give the title compound as an oil, yield 3.3 g. 1 H N.M.R. (CDCl3) delta=7.10 (s, 1H); 7.00 (d, 1H); 6.75 (m, 1H); 4.65-4.55 (m, 2H); 3.90-3.75 (m, 2H); 3.30-3.15 (m, 2H); 2.90-2.80 (m, 2H); 1.85-1.75 (brs, 1H) ppm.

69999-16-2 2,3-Dihydrobenzofuranyl-5-acetic acid 2737455, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US5219871; (1993); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 496-16-2

As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

496-16-2, 2,3-Dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Take a 1001 ^ three mouth reaction bottle,2,3-dihydrobenzofuran (128, 0.1111) was dissolved in nitrogen,Nitrogen-dimethylformamide (120 g, 1.64 mil) was placed in a reaction flask,Heated to 70 ¡ã C to 80 ¡ã C in 2 hours with mechanical agitation, In part by adding phosphorus pentachloride / nitrogen,Nitrogen-dimethylformamide mixed formylating reagent (25 g, 0.2 mol).The reaction mixture was incubated for 8 hours.After the reaction,The reaction mixture was added dropwise to ice water (l0 g) and stirred at room temperature for 5 hours.Toluene 50mL extraction,Organic layer followed by water,Saturated aqueous sodium bicarbonate solution and washed with water,Dried over anhydrous sodium sulfate,filter,The organic layer was concentrated to give product 2, 3-dihydrobenzofuran-5-carbaldehyde (14. 5 g, 0.08 mil).This product can be used for the production of lamivudine., 496-16-2

As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

Reference£º
Patent; Hangzhou Duyi Technology Co., Ltd.; Bian Gaofeng; Wang Jian; Zheng Zengying; Li Zhenye; (7 pag.)CN106554345; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 641-70-3

641-70-3 3-Nitrophthalic anhydride 21631, abenzofuran compound, is more and more widely used in various fields.

641-70-3, 3-Nitrophthalic anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

641-70-3, 52.5 g (0.27 mol) of 3-nitrophthalic anhydride were stirred in portions over the course of 30 minutes into 75 ml of concentrated aqueous ammonia at room temperature. The mixture was then cooled to 0 C., after which a precipitate crystallized out and was filtered off with suction. This precipitate was dissolved in 125 ml of water by gently heating, and 25.6 ml of 32% strength hydrochloric acid were rapidly added. The mixture was cooled to 0 C., and the crystals which separated out were filtered off with suction. 45 g of the product were obtained.

641-70-3 3-Nitrophthalic anhydride 21631, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Abbott GmbH & Co. KG; US6737421; (2004); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 24410-61-5

24410-61-5, As the paragraph descriping shows that 24410-61-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24410-61-5,7-Fluorobenzofuran,as a common compound, the synthetic route is as follows.

Step 1 Preparation of 7-fluorobenzo[b]furan-2-ylsulfonyl chloride. Starting from 7-fluorobenzo[b]furan (10.4 g), the objective compound (5.7 g) was obtained in a manner similar to Step 1 of Example 91.

24410-61-5, As the paragraph descriping shows that 24410-61-5 is playing an increasingly important role.

Reference£º
Patent; Mochida Pharmaceutical Co., Ltd.; US5004751; (1991); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem