Tag: 100-200

Evidence of a peri effect in the benzofuran series was written by Belleney, Joel;Vebrel, Joel;Platzer, Nicole;Theobald, Francois. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1983.Synthetic Route of C10H8O3 This article mentions the following:

The synthesis of 2,3-dimethoxycarbonylbenzofuran, of its 4 monomethyl derivatives, and of some di- and tri-Me derivatives allowed their structural anal. by ¹³C NMR and mass spectrometry to be studied. The importance of electronic and steric interactions in these compounds is observed The crystal structure of 2,3-dimethoxycarbonyl-4-methylbenzofuran was determined from 172 independent reflections and refined to R 0.044. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Synthetic Route of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Synthetic Route of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹⁸F-PET imaging agents for β-amyloid plaques was written by Swahn, Britt-Marie;Sandell, Johan;Pyring, David;Bergh, Margareta;Jeppsson, Fredrik;Jureus, Anders;Neelissen, Jan;Johnstroem, Peter;Schou, Magnus;Svensson, Samuel. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.HPLC of Formula: 551001-79-7 This article mentions the following:

The synthesis and SAR of new β-amyloid binding agents are reported. Evaluation of important properties for achieving good signal-to-background ratio is described. 2-(2-Fluoro-6-methylamino-3-pyridinyl)-6-benzofuranol (I), 2-(3-fluoro-2-methylamino-5-pyridinyl)-6-benzofuranol, and 2-(2-fluoro-3-methylamino-6-pyridinyl)-6-benzofuranol displayed desirable lipophilic and pharmacokinetic properties. I was further evaluated with autoradiog. studies in vitro on human brain tissue and in vivo in Tg2576 mice. I showed an increased signal-to-background ratio compared to flutemetamol, indicating its suitability as PET ligand for β-amyloid deposits in AD patients. The preparation of the corresponding ¹⁸F-labeled PET radioligand of I is presented. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7HPLC of Formula: 551001-79-7).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.HPLC of Formula: 551001-79-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reversible energy transfer and oxetane formation in the photoreactions of carbonyl compounds with benzofurans was written by Farid, S.;Hartman, S. E.;DeBoer, C. D.. And the article was included in Journal of the American Chemical Society in 1975.COA of Formula: C10H8O3 This article mentions the following:

The photoreactions of propiophenone and acetophenone with benzofuran lead both to dimerization of the olefin and to oxetane formation. The dependency of the product ratio on the concentration of the reactants can be rationalized in terms of 2 different mechanisms. Kinetic studies gave support for the mechanism involving a reversible energy-transfer step as a reaction competing with the oxetane formation. The data implied, however, that the difference in triplet energies of propiophenone and acetophenone is much smaller than the reported values, which were derived from the phosphorescence spectra in glasses. This apparent contradiction was eliminated by establishing that both ketone triplets in benzene at room temperature are practically isoenergetic. This was concluded from a chem. kinetic study based on competing oxetane formation from both ketones with 2-methyl-2-butene. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1COA of Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Direct Amidation of Esters by Ball Milling was written by Nicholson, William I.;Barreteau, Fabien;Leitch, Jamie A.;Payne, Riley;Priestley, Ian;Godineau, Edouard;Battilocchio, Claudio;Browne, Duncan L.. And the article was included in Angewandte Chemie, International Edition in 2021.Name: Methyl benzofuran-2-carboxylate This article mentions the following:

The direct mechanochem. amidation of esters RC(O)OR¹ (R = Cy, Ph, pyridin-2-yl, etc.; R¹ = Me, Et) by ball milling is described. The operationally simple procedure requires an ester, amines R²NHR³ (R² = H, Me, Et; R³ = i-Pr, Ph, 2,4,6-trimethylphenyl, etc.; R²R³ = -(CH₂)₂O(CH₂)₂-, -(CH₂)₅-, -(CH₂)₆-, etc.) and 1,2,3,4-tetrahydroquinoline, and substoichiometric KOtBu, and was used to prepare a large and diverse library of 78 amide structures RC(O)N(R²)R³ and (3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochem. protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochems. as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Name: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Name: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Palladium-Catalyzed Direct Arylation of Polysubstituted Benzofurans was written by Carrer, Amandine;Brinet, Dimitri;Florent, Jean-Claude;Rousselle, Patricia;Bertounesque, Emmanuel. And the article was included in Journal of Organic Chemistry in 2012.Reference of 1646-27-1 This article mentions the following:

An efficient access to 2-substituted 3-arylbenzofurans, e.g., I, through a palladium-catalyzed C3 direct arylation of 2-substituted benzofurans with aryl bromides is described. The scope and limitation of this reaction was studied. The method tolerates a variety of functional groups on the aryl halide and has been successfully extended to polysubstituted benzofurans to obtain the corresponding 3-arylbenzofurans with good to excellent yields. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Reference of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Reference of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Studies in benzofurans: Part III. Synthesis and reactions of 2-alkyl- or 2-aryl-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidines and 4-thio analogs was written by Sangapure, S. S.;Agasimundin, Y. S.. And the article was included in Indian Journal of Chemistry in 1978.Application of 54802-10-7 This article mentions the following:

3-Amino-2-benzofurancarboxamide underwent acylation-cyclization by treatment with AcCl or BzCl and alkali to give benzofuro[3,2-d]pyrimidinones I [Z = O, R = Me (II), Ph]. Treatment of II with POCl₃ gave III, which with thiourea gave the thione (I; Z = S, R = Me). The latter was also prepared directly from II and P₂S₅. The thione underwent S-alkylation by treatment with alkyl halide and aqueous alkali. The substitution reactions of III with Na alkoxides, phenols, thiophenols, and aliphatic and aromatic amines are described. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and characterisation of copper(II) complexes with 2,3-substituted benzofuran schiff bases was written by Halli, M. B.;Qureshi, Z. S.;Basavaraj, A.. And the article was included in Journal of Saudi Chemical Society in 2002.Product Details of 54802-10-7 This article mentions the following:

The complexes Cu.L.Cl₂ where, L = Schiff base derived from the condensation of 3-amino-2-benzofurancarboxamide/ethyl-3-amino-2-benzofurancarboxylate with substituted benzaldehydes/acetophenone were synthesized. The complexes were characterized by elemental analyses, magnetic susceptivity, conductance measurements as well as electronic, ESR and IR spectral data. The spectral studies show that schiff base behaves as a neutral bidentate in all the complexes. The ligands and their complexes were evaluated for their antibacterial and anthelmintic activities (no data). In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Product Details of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Product Details of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Infrared spectra of some substituted benzofuran derivatives was written by Epstein, W. W.;Horton, W. J.;Lin, C. T.. And the article was included in Journal of Organic Chemistry in 1965.Recommanded Product: 1646-27-1 This article mentions the following:

The ir spectra of a number of simple and complex substituted benzofurans (I) were studied. The findings indicated a relationship between the presence or absence of furan H atoms and medium to strong bands in the 1020-1180-cm.^-1 region. I were divided into 2 groups. One group wherein R¹ = H and the 2nd group in which R¹ = COMe, CO₂Me, CO₂H, iso-Pr, iso-PrCO, C:CHMe, and COCH₂COMe. The 1st had 2 bands, one in the 1125-1160cm.^-1 region and the other in the 1029-1087-cm.^-1 region associated with the in-plane bending modes of the β- and α-H atoms on the furan nucleus. The 2nd had only 1 band at 1121-1172 cm.^-1 characteristic of the β-H. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Direct Synthesis of Ketones from Methyl Esters by Nickel-Catalyzed Suzuki-Miyaura Coupling was written by Zheng, Yan-Long;Xie, Pei-Pei;Daneshfar, Omid;Houk, Kendall N.;Hong, Xin;Newman, Stephen G.. And the article was included in Angewandte Chemie, International Edition in 2021.Name: Methyl benzofuran-2-carboxylate This article mentions the following:

The direct conversion of alkyl esters to ketones has been hindered by the sluggish reactivity of the starting materials and the susceptibility of the product towards subsequent nucleophilic attack. We have now achieved a cross-coupling approach to this transformation using nickel, a bulky N-heterocyclic carbene ligand, and alkyl organoboron coupling partners. 65 Alkyl ketones bearing diverse functional groups and heterocyclic scaffolds have been synthesized with this method. Catalyst-controlled chemoselectivity is observed for C(acyl)-O bond activation of multi-functional substrates bearing other bonds prone to cleavage by Ni, including aryl ether, aryl fluoride, and N-Ph amide functional groups. D. functional theory calculations provide mechanistic support for a Ni⁰/Ni^II catalytic cycle and demonstrate how stabilizing non-covalent interactions between the bulky catalyst and substrate are critical for the reaction’s success. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Name: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Name: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rhenium and technetium complexes of thioamide derivatives of pyridylhydrazine that bind to amyloid-β plaques was written by Fletcher, Scott P.;Noor, Asif;Hickey, James L.;McLean, Catriona A.;White, Jonathan M.;Donnelly, Paul S.. And the article was included in JBIC, Journal of Biological Inorganic Chemistry in 2018.Computed Properties of C9H9BO4 This article mentions the following:

Abstract: Age-associated deposition of amyloid-β in cerebral blood vessels, a condition referred to as cerebral amyloid angiopathy, can contribute to stroke and dementia. This research aimed to design new radioactive technetium-99 m complexes that bind to amyloid-β plaques that have the potential to assist in diagnosis of cerebral amyloid angiopathy using single-photon-emitted computed tomog. (SPECT) imaging. Six new pyridylthiosemicarbazide ligands containing either benzofuran or styrylpyridyl functional groups that are known to selectively bind to amyloid plaques were prepared Non-radioactive isotopes of technetium are not available so rhenium was used as a surrogate for exploratory chem. The new ligands were used to prepare well-defined [Re-oxo]³⁺ complexes where two pyridylthiosemicarbazide ligands were coordinated to a single metal ion to give bivalent complexes with two amyloid-β targeting functional groups. The interaction of the [Re-oxo]³⁺ complexes with synthetic amyloid-β_1-42 and with amyloid plaques in human brain tissue was investigated. Two ligands were selected to develop methods to prepare their [^99mTc-oxo]³⁺ complexes at the tracer level. These technetium-99 m complexes are likely to be isostructural to their rhenium-oxo analogs. Graphical abstract: [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Computed Properties of C9H9BO4).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C9H9BO4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem