Studies in benzofurans: Part III. Synthesis and reactions of 2-alkyl- or 2-aryl-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidines and 4-thio analogs was written by Sangapure, S. S.;Agasimundin, Y. S.. And the article was included in Indian Journal of Chemistry in 1978.Application of 54802-10-7 This article mentions the following:
3-Amino-2-benzofurancarboxamide underwent acylation-cyclization by treatment with AcCl or BzCl and alkali to give benzofuro[3,2-d]pyrimidinones I [Z = O, R = Me (II), Ph]. Treatment of II with POCl3 gave III, which with thiourea gave the thione (I; Z = S, R = Me). The latter was also prepared directly from II and P2S5. The thione underwent S-alkylation by treatment with alkyl halide and aqueous alkali. The substitution reactions of III with Na alkoxides, phenols, thiophenols, and aliphatic and aromatic amines are described. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).
3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application of 54802-10-7
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem