Tag: 100-200

Khusnutdinov, R. I. et al. published their research in Russian Journal of Organic Chemistry in 2011 | CAS: 1646-27-1

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: Methyl benzofuran-2-carboxylate

Synthesis of 1-benzofuran-2-carboxylates by reaction of 1-benzofuran with halomethanes and alcohols in the presence of iron compounds was written by Khusnutdinov, R. I.;Baiguzina, A. R.;Mukminov, R. R.. And the article was included in Russian Journal of Organic Chemistry in 2011.Recommanded Product: Methyl benzofuran-2-carboxylate This article mentions the following:

Alkyl 1-benzofuran-2-carboxylates were obtained in quant. yield by reaction of 1-benzofuran with halomethanes and alcs. in the presence of iron-containing catalysts both in the presence and in the absence of radical initiators. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wei, Haidong et al. published their research in Synthesis in 2013 | CAS: 54802-10-7

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Copper-catalyzed domino synthesis of quinazolin-4(3H)-ones from (hetero)arylmethyl halides, bromoacetate, and cinnamyl bromide was written by Wei, Haidong;Li, Tianbin;Zhou, Yue;Zhou, Lihong;Zeng, Qingle. And the article was included in Synthesis in 2013.Category: benzofurans This article mentions the following:

Alkyl halides, including heteroarylmethyl and arylmethyl halides, bromoacetate, and cinnamyl bromide, are readily prepared via halogenation from basic raw materials, even using green processes (no data). It is essential to replace their downstream products with them to prepare medicinally important heterocycles quinazolin-4(3H)-ones. Copper(I) bromide catalyzed domino reaction of alkyl halides and anthranilamides under air affords 2-substituted quinazolin-4(3H)-ones in good to excellent yields and with wide functional group tolerance. A mechanism for a copper(I) bromide involved organometal-catalyzed reaction via a four-step domino reaction is proposed. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Category: benzofurans).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Satheeshkumar, K. et al. published their research in Inorganic Chemistry Communications in 2022 | CAS: 54802-10-7

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 54802-10-7

An easy to make Hg(II) complex as a selective and sensitive fluorescent turn-on chemosensor for iodide in an aqueous solution based on metal ion displacement mechanism was written by Satheeshkumar, K.;Saravana Kumar, P.;Shanmugapriya, R.;Nandhini, C.;Vennila, K. N.;Elango, Kuppanagounder P.. And the article was included in Inorganic Chemistry Communications in 2022.Product Details of 54802-10-7 This article mentions the following:

A simple Schiff base ligand (L) bearing 3,5-dibromo-2-hyrdoxybenzaldehyde fluorophore moiety has rationally been designed, synthesized and characterized. The Hg(II) complex of L was synthesized by simply stirring a mixture of L and HgCl2 in ethanol at RT and the resultant non-fluorescent complex HgL is found to detect iodide ion selectively, with a turn-on fluorescence in H2O:DMSO (1:1 volume/volume) medium. The detection of iodide was performed via the metal ion displacement mechanism with a 1:2 (Probe:Iodide) stoichiometry and binding constant of 1.51 × 104 M-1. Novel HgL complex showed rapid response towards iodide ion with a limit of detection (LOD) as low as 60 nM. Moreover, the sensing mechanism of iodide by the complex is theor. supported by d. functional theory (DFT) and time dependent d. functional theory (TD-DFT) calculations In addition, estimation of iodide in real water samples, table salt and urine sample demonstrate the practical value of the probe. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Product Details of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Trofimov, F. A. et al. published their research in Khimiya Geterotsiklicheskikh Soedinenii in 1975 | CAS: 54802-10-7

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C9H8N2O2

2-Acyl-3-aminobenzofurans. II. Synthesis of heterocyclic systems consisting of 2-acyl-3-aminobenzofuran derivatives was written by Trofimov, F. A.;Shevchenko, L. I.;Lelyak, G. F.;Grinev, A. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.COA of Formula: C9H8N2O2 This article mentions the following:

Cyclization of I (R = Ac, R1 = OH) by Ac2O gave 87% benzofurooxazine II; cyclization by PhNH2 gave 54% III (R = Me, R1 = Ph). Treatment of I (R = H, R1 = OMe) with CH(OEt)3 gave 15% III (R = R1 = H); treatment with O-methylcaprolactam gave 35% III [RR1 = (CH2)5]. Treatment of I (R = ClCH2CO, R1 = Ph) with urotropine gave IV. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7COA of Formula: C9H8N2O2).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C9H8N2O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Andrisano, Renato et al. published their research in Ricerca sci. in 1960 | CAS: 1646-27-1

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C10H8O3

Near-ultraviolet absorption spectra of some furan and benzofuran derivatives. Observations on relation with chemical properties was written by Andrisano, Renato. And the article was included in Ricerca sci. in 1960.Electric Literature of C10H8O3 This article mentions the following:

The relation between aromatic character and ultraviolet spectra of heterocyclic compounds is discussed. Comparison of the spectra of the hydrocarbons and their acetyl derivatives gave the order of aromaticity of benzene > thiophene > pyrrole > furan, selenophene ≥ thiophene, and α-furanyl > β-furanyl. The spectra of some derivatives of benzofuran (I) are recorded. 2-Methylbenzofuran has a spectrum very similar to that of I, but benzofuran-2-carboxylic acid and the Me ester are displaced to higher wave length, due to the increased conjugation. 2-, 4-, 5-, 6- and 7-Nitro substituents also increases the wave length, decreasing in that order. The shifts are similar in nitro-2,3-dimethylindoles. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Electric Literature of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kobayashi, Jun-ichi et al. published their research in Bioorganic & Medicinal Chemistry in 2021 |CAS: 1459793-02-2

The Article related to trpm8 antagonist adverse event, cyp3a4 induction, oab, phenylglycinamide, reactive metabolite, trpm8, trpm8 antagonist, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Recommanded Product: 1459793-02-2

On January 15, 2021, Kobayashi, Jun-ichi; Hirasawa, Hideaki; Fujimori, Yoshikazu; Nakanishi, Osamu; Kamada, Noboru; Ikeda, Tetsuya; Yamamoto, Akitoshi; Kanbe, Hiroki published an article.Recommanded Product: 1459793-02-2 The title of the article was Identification of N-acyl-N-indanyl-α-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects. And the article contained the following:

Transient receptor potential melastatin 8 (TRPM8), a temperature-sensitive ion channel responsible for detecting cold, is an attractive mol. target for the treatment of pain and other disorders. We have previously discovered a selective TRPM8 antagonist, KPR-2579, which inhibited bladder afferent hyperactivity induced by acetic acid instillation into the bladder. However, addnl. studies have revealed potential adverse effects with KPR-2579, such as the formation of a reactive metabolite, CYP3A4 induction, and convulsions. In this report, we describe the optimization of α-phenylglycinamide derivatives to mitigate the risk of these adverse effects. The optimal compound 13x exhibited potent inhibition against icilin-induced wet-dog shakes and cold-induced frequent voiding in rats, with a wide safety margin against the potential side effects. The experimental process involved the reaction of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride(cas: 1459793-02-2).Recommanded Product: 1459793-02-2

The Article related to trpm8 antagonist adverse event, cyp3a4 induction, oab, phenylglycinamide, reactive metabolite, trpm8, trpm8 antagonist, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Recommanded Product: 1459793-02-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rochette, Elise M. et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2013 |CAS: 1459793-02-2

The Article related to chiral sulfinimide radical stereoselective cyclization, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C8H10ClNO

Rochette, Elise M.; Lewis, William; Dossetter, Al G.; Stockman, Robert A. published an article in 2013, the title of the article was Highly diastereoselective radical cyclisations of chiral sulfinimines.Formula: C8H10ClNO And the article contains the following content:

Chiral amines are formed by the highly diastereoselective intramol. addition of alkyl and aryl radicals onto chiral mesityl sulfinimines. The experimental process involved the reaction of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride(cas: 1459793-02-2).Formula: C8H10ClNO

The Article related to chiral sulfinimide radical stereoselective cyclization, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C8H10ClNO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nakanishi, Teruo et al. published their research in Seikagaku in 1970 |CAS: 29735-85-1

The Article related to benzofurans inhibition deaminases, deaminases inhibition benzofurans, inhibition deaminases benzofurans, amp deaminase inhibition benzofurans, and other aspects.Quality Control of 5-Hydroxybenzofuran-3-carboxylic acid

Nakanishi, Teruo; Saeki, Toru published an article in 1970, the title of the article was Inhibitory action of benzofuran compounds on 5′-AMP deaminase and adenosine deaminase.Quality Control of 5-Hydroxybenzofuran-3-carboxylic acid And the article contains the following content:

The inhibitory action of benzofuran derivatives on 5′-AMP deaminase (I) and adenosine deaminase (II) was investigated by using a number of synthetic compounds Introduction of carboxyl or hydroxyl groups increased the inhibitory action on I, but no pronounced effect of the substituent was observed on II. No common feature in structure seems to exist for the inhibition of these 2 deaminases. The experimental process involved the reaction of 5-Hydroxybenzofuran-3-carboxylic acid(cas: 29735-85-1).Quality Control of 5-Hydroxybenzofuran-3-carboxylic acid

The Article related to benzofurans inhibition deaminases, deaminases inhibition benzofurans, inhibition deaminases benzofurans, amp deaminase inhibition benzofurans, and other aspects.Quality Control of 5-Hydroxybenzofuran-3-carboxylic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Andrews, Mark et al. published their patent in 2021 |CAS: 29735-85-1

The Article related to heteroaryl aryl amidoamide preparation il17 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 29735-85-1

On December 16, 2021, Andrews, Mark; Soerensen, Morten Dahl; Larsen, Mogens; Devaux, Nicolas; Barros Ribeiro da Silva, Vicinius; Perron, Quentin; Liang, Xifu; Seitzberg, Jimmi Gerner published a patent.Recommanded Product: 29735-85-1 The title of the patent was N-Heteroaryl and N-aryl amidoamides as small molecule modulators of IL-17 and their preparation. And the patent contained the following:

The invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments. Compounds of formula I wherein X, Y, Z and V are independently N, CH and CR4; R1 is (un)substituted C1-4 alkyl, (un)substituted C3-7 cycloalkyl, C1-6 alkoxy, (un)substituted Ph, etc.; R2 is (un)substituted 5- to 6-membered heteroaryl; R3 is CHR5R6, (un)substituted C3-10 cycloalkyl, (un)substituted tetrahydronaphthyl, etc.; R4 is (un)substituted C1-6 alkyl, (un)substituted C1-6 alkoxy, OH, NH2 and halo; R5 and R6 are independently H, (un)substituted Ph, (un)substituted C1-6 alkyl, (un)substituted C3-7 cycloalkyl, etc.; and pharmaceutically acceptable salts, hydrates and solvates thereof, are claimed. Example compound II was prepared by deprotection of N-[(1S)-1-(dicyclopropylmethyl)-2-[[5-[3,5-dimethyl-1-(2-trimethylsilylethoxymethyl)pyrazol-4-yl]-6-fluoro-2-pyridyl]amino]-2-oxo-ethyl]-2-isopropylpyrazole-3-carboxamide. The invention compounds were evaluated for their IL-17 modulatory activity. From the assay, it was determined that compound II exhibited EC50 value of 15 nM. The experimental process involved the reaction of 5-Hydroxybenzofuran-3-carboxylic acid(cas: 29735-85-1).Recommanded Product: 29735-85-1

The Article related to heteroaryl aryl amidoamide preparation il17 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 29735-85-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hirasawa, Hideaki et al. published their patent in 2016 |CAS: 1459793-02-2

The Article related to glycine amide preparation trpm8 inhibitor, nerve hyperexcitability disease treatment glycine amide trpm8 inhibition, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Application In Synthesis of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride

On May 26, 2016, Hirasawa, Hideaki; Kawamura, Naohiro; Kobayashi, Junichi published a patent.Application In Synthesis of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride The title of the patent was TRPMB inhibitors containing α-substituted glycine amides. And the patent contained the following:

Disclosed is a pharmaceutical composition containing a compound I [A1 = C6-10 aryl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.), 5-membered heterocyclyl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.) or 6-membered heterocyclyl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.); A2 = C6-10 aryl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.), heterocyclyl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.) or C3-6 cycloalkyl; X = CH or N; Y = -CR1R2- or oxygen atom; R1, R2 = independently H, halo or C1-6 alkyl; R3, R4 = independently H, halo, C1-6 alkyl, etc., wherein R3 and R4 cannot be H together when X = CH and R1 = R2 = H; n = 1 or 2], or pharmaceutically acceptable salt thereof as an active component. The composition is claimed useful for the treatment of diseases or conditions associated with afferent nerve hyperexcitability or injury, e.g. LUTS (lower urinary tract symptoms). For example, a compound (II) showed potent inhibitory effect on icilin-induced wet-dog shaking in rat. The experimental process involved the reaction of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride(cas: 1459793-02-2).Application In Synthesis of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride

The Article related to glycine amide preparation trpm8 inhibitor, nerve hyperexcitability disease treatment glycine amide trpm8 inhibition, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Application In Synthesis of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem