Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques was written by Swahn, Britt-Marie;Sandell, Johan;Pyring, David;Bergh, Margareta;Jeppsson, Fredrik;Jureus, Anders;Neelissen, Jan;Johnstroem, Peter;Schou, Magnus;Svensson, Samuel. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.HPLC of Formula: 551001-79-7 This article mentions the following:
The synthesis and SAR of new β-amyloid binding agents are reported. Evaluation of important properties for achieving good signal-to-background ratio is described. 2-(2-Fluoro-6-methylamino-3-pyridinyl)-6-benzofuranol (I), 2-(3-fluoro-2-methylamino-5-pyridinyl)-6-benzofuranol, and 2-(2-fluoro-3-methylamino-6-pyridinyl)-6-benzofuranol displayed desirable lipophilic and pharmacokinetic properties. I was further evaluated with autoradiog. studies in vitro on human brain tissue and in vivo in Tg2576 mice. I showed an increased signal-to-background ratio compared to flutemetamol, indicating its suitability as PET ligand for β-amyloid deposits in AD patients. The preparation of the corresponding 18F-labeled PET radioligand of I is presented. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7HPLC of Formula: 551001-79-7).
(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.HPLC of Formula: 551001-79-7
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem