Palladium-Catalyzed Direct Arylation of Polysubstituted Benzofurans was written by Carrer, Amandine;Brinet, Dimitri;Florent, Jean-Claude;Rousselle, Patricia;Bertounesque, Emmanuel. And the article was included in Journal of Organic Chemistry in 2012.Reference of 1646-27-1 This article mentions the following:
An efficient access to 2-substituted 3-arylbenzofurans, e.g., I, through a palladium-catalyzed C3 direct arylation of 2-substituted benzofurans with aryl bromides is described. The scope and limitation of this reaction was studied. The method tolerates a variety of functional groups on the aryl halide and has been successfully extended to polysubstituted benzofurans to obtain the corresponding 3-arylbenzofurans with good to excellent yields. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Reference of 1646-27-1).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Reference of 1646-27-1
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem