Category: benzofurans

1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, belongs to benzofurans compound, is a common compound. SDS of cas: 1563-38-8In an article, once mentioned the new application about 1563-38-8.

A new methodology for the retrospective screening of pesticide metabolites in ambient air was developed, using liquid chromatography coupled to Orbitrap high-resolution mass spectrometry (UHPLC-HRMS), including two systematic workflows (i) post-run target screening (suspect screening) and (ii) non-target screening. An accurate-mass database was built and used for the post-run screening analysis. The database contained 240 pesticide metabolites found in different matrixes such as air, soil, water, plants, animals and humans. For non-target analysis, a “fragmentation-degradation” relationship strategy was selected. The proposed methodology was applied to 31 air samples (PM10) collected in the Valencian Region (Spain). In the post-target analysis 34 metabolites were identified, of which 11 (3-ketocarburan, carbofuran-7-phenol, carbendazim, desmethylisoproturon, ethiofencarb-sulfoxide, malaoxon, methiocarb-sulfoxide, N-(2-ethyl-6-methylphenyl)-L-alanine, omethoate, 2-hydroxy-terbuthylazine, and THPAM) were confirmed using analytical standards. The semiquantitative estimated concentration ranged between 6.78 and 198.31 pg m-3. Likewise, two unknown degradation products of malaoxon and fenhexamid were elucidated in the non-target screening.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2387O – PubChem

Reference of 54450-20-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 54450-20-3, molcular formula is C8H5BrO2, introducing its new discovery.

Compounds in a structurally novel series of substituted 10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acids and related 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids were prepared and shown to possess potent, bladder-selective smooth muscle relaxant properties and thus are potentially useful for the treatment of urge urinary incontinence. Electrophysiological studies using rat detrusor myocytes have demonstrated that prototype compound 7 produces a significant increase in hyperpolarizing current, which is iberiotoxin (IbTx)-reversed, thus consistent with activation of the large-conductance Ca2+-activated potassium channel (BKCa).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 54450-20-3 is helpful to your research. Reference of 54450-20-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3604O – PubChem

Related Products of 496-41-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Article，once mentioned of 496-41-3

Lysine specific demethylase 1 (LSD1) plays a vital role in epigenetic regulation of gene activation and repression in several human cancers and is recognized as a promising antitumor therapeutic target. In this paper, a series of 4-(4-benzyloxy)phenoxypiperidines were synthesized and evaluated. Among the tested compounds, compound 10d exhibited the potent and reversible inhibitory activity against LSD1 in vitro (IC50 = 4 muM). Molecular docking was conducted to predict its binding mode. Furthermore, 10d displayed it could inhibit migration of HCT-116 colon cancer cells and A549 lung cancer cells. Taken together, 10d deserves further investigation as a hit-to-lead for the treatment of LSD1 associated tumors.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2027O – PubChem

24673-56-1, Name is 3-Methylbenzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. Safety of 3-Methylbenzofuran-2-carboxylic acidIn an article, once mentioned the new application about 24673-56-1.

Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2709O – PubChem

Synthetic Route of 4265-16-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4265-16-1, molcular formula is C9H6O2, introducing its new discovery.

The HTS-based discovery and structure-guided optimization of a novel series of GKRP-selective GK-GKRP disrupters are revealed. Diarylmethanesulfonamide hit 6 (hGK-hGKRP IC50 = 1.2 muM) was optimized to lead compound 32 (AMG-0696; hGK-hGKRP IC50 = 0.0038 muM). A stabilizing interaction between a nitrogen atom lone pair and an aromatic sulfur system (nN ? sigmaS-X) in 32 was exploited to conformationally constrain a biaryl linkage and allow contact with key residues in GKRP. Lead compound 32 was shown to induce GK translocation from the nucleus to the cytoplasm in rats (IHC score = 0; 10 mg/kg po, 6 h) and blood glucose reduction in mice (POC = -45%; 100 mg/kg po, 3 h). X-ray analyses of 32 and several precursors bound to GKRP were also obtained. This novel disrupter of GK-GKRP binding enables further exploration of GKRP as a potential therapeutic target for type II diabetes and highlights the value of exploiting unconventional nonbonded interactions in drug design.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4265-16-1 is helpful to your research. Synthetic Route of 4265-16-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H995O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of Crystal violet lactone. Introducing a new discovery about 1552-42-7, Name is Crystal violet lactone

Disclosed is a thermochromic microencapsulated pigment which comprises as four essential components (a) an electron-donating chromatic organic compound, (b) an electron-accepting compound, (c) a reaction medium determining the temperatures at which the color reactions of component (a) with component (b) take place, and (d) a color change temperature regulator, the color change temperature regulator (d) comprising one or more compounds selected from the group consisting of esters, alcohols, ketones, acid amides, hydrocarbons, and fatty acids and having a melting point Y ( C.) satisfying the relationship (X+30) C.<=Y<=200 C., wherein X ( C.) is the melting point of component (c), and the four essential components being microencapsulated. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of Crystal violet lactone, you can also check out more blogs about1552-42-7

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4137O – PubChem

Application of 69604-00-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 69604-00-8, Name is Ethyl 5-nitrobenzofuran-2-carboxylate, molecular formula is C11H9NO5. In a Patent，once mentioned of 69604-00-8

The present invention provides a pyrimidine heterocyclic compound, pyrimidine heterocyclic compound salt and preparation method and application, the present invention provides compounds of formula (I) pyrimidine heterocyclic compound, through the selection of a particular Rq, so that the obtained compound as the treatment or prevention of anti-HIV virus drugs, not only has very good drug resistance and long half-life, but also the compound active high, low in toxicity and high stability. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 69604-00-8. In my other articles, you can also check out more blogs about 69604-00-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3862O – PubChem

Reference of 10242-11-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 10242-11-2, 5-Bromobenzofuran-2-carboxylic acid, introducing its new discovery.

The present invention includes antagonists of human type 2 taste receptors (hT2Rs) having structural Formula (I).The present invention also provides compositions containing these antagonists, the use of these antagonists for modulating taste perception, particularly bitter taste, and the method of preparing these antagonists (I).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 10242-11-2. In my other articles, you can also check out more blogs about 10242-11-2

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3912O – PubChem

64175-51-5, Name is 2-(Benzofuran-3-yl)acetic acid, belongs to benzofurans compound, is a common compound. Recommanded Product: 2-(Benzofuran-3-yl)acetic acidIn an article, once mentioned the new application about 64175-51-5.

We report the development of palladium(0)-catalyzed syn-selective 1,2-carboboration and -silylation reactions of alkenes containing cleavable directing groups. With B2pin2 or PhMe2Si-Bpin as nucleophiles and aryl/alkenyl triflates as electrophiles, a broad range of mono-, di-, tri- and tetrasubstituted alkenes are compatible in these transformations. We further describe a directed dearomative 1,2-carboboration of electron-rich heteroarenes by employing this approach. Through use of a removable chiral directing group, we demonstrate the viability of achieving stereoinduction in Heck-type alkene 1,2-difunctionalization. This work introduces new avenues to access highly functionalized boronates and silanes with precise regio- and stereocontrol.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2673O – PubChem

Related Products of 1280665-55-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1280665-55-5, Name is Methyl 7-amino-2,3-dihydrobenzofuran-4-carboxylate, molecular formula is C10H11NO3. In a article，once mentioned of 1280665-55-5

The invention relates to azabicyclo [3.2.1] octane derivatives, their preparation and their use in medicine. Specifically, the invention relates to a compound of general formula (I) indicated by the azabicyclo [3.2.1] octane derivatives, preparation method thereof and its pharmaceutically acceptable salts, and their use as therapeutic agents, in particular the use of the FXR agonists, of formula (I) in the definition of each substituent as defined in the specification. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3120O – PubChem