Category: benzofurans

Electric Literature of 569-31-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 569-31-3, Name is 6,7-Dimethoxy-3H-1-isobenzofuranone, molecular formula is C10H10O4. In a Article，once mentioned of 569-31-3

7-Methoxyphthalide (3a) and meconine (3b) have been synthesised by the lithiation of appropriate N,N-dimethylbenzylamines (1a and 1b) followed by the reaction of the lithium derivatives with ethylchloroformate.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 569-31-3. In my other articles, you can also check out more blogs about 569-31-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3147O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 4-Aminophthalide, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 59434-19-4, Name is 4-Aminophthalide, molecular formula is C8H7NO2

The 13C and 1H NMR spectra of several phthalides, phthalimides, phthalimidines and 1-hydroxyphthalimidines, many of them bearing an amino substituent at the aromatic ring, have been recorded and analysed.Chemical shifts were correlated by multiple linear regression analysis and substituent shift parameters were calculated.In most cases, standard deviations were lower than 0.5 ppm for 13C and 0.05 ppm for 1H spectra.Agreement between calculated and experimental shifts was satisfactory and permitted unequivocal structure assignment.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1354O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 4687-25-6, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4687-25-6, Name is Benzofuran-3-carbaldehyde, molecular formula is C9H6O2

Based on examples of the successful applications in drug discovery of bioisosterism, a series of streptochlorin analogues in which indole has been replaced by other heterocycles has been designed and synthesized, as a continuation of our studies aimed at the discovery of novel streptochlorin analogues with improved antifungal activity. Biological testing showed that most of the indole-replaced streptochlorin analogues were inactive, though compound 6f had a broad spectrum of antifungal activity with significant activity against Alternaria solani. The SAR study demonstrated that indole ring is an essential moiety for the antifungal activity of streptochlorin analogues, promoting the idea of indole ring as a framework that might be exploited in the future.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Product Details of 4687-25-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 4687-25-6

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1222O – PubChem

Application of 57319-65-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 57319-65-0, molcular formula is C8H7NO2, introducing its new discovery.

To improve the pharmacokinetics of a previously reported series of dipeptidyl nitrile cathepsin B inhibitors, the P2-P3 amide group was replaced with an arylamine. Further optimization of this template resulted in highly potent and selective inhibitors with excellent oral availability.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 57319-65-0 is helpful to your research. Application of 57319-65-0

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1388O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Product Details of 652-12-0. Introducing a new discovery about 652-12-0, Name is Tetrafluorophthalic anhydride

Structurally modified phthalimide derivatives were prepared through condensation of phthalic and tetrafluorophthalic anhydride with selected sulfonamides with variable yields. All compounds were screened for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) using a micro broth dilution technique. The fluorinated derivatives (compounds 2c, 2d, 2f and 2h) had antimycobacterium activity comparable with classical sulfonamide drugs. The minimum inhibitory concentration (MIC) of compounds 2c, 2d, 2f and 2h was greater than that of isoniazid (MIC <0.02 mug/mL) and in vitro activity was greater than that of pyrazinamide, another first line antimycobacterium drug (MIC 50-100 mug/mL). The new compounds could be considered new lead compounds in the treatment of multi-drug resistant tuberculosis. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 652-12-0, you can also check out more blogs about652-12-0

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3700O – PubChem

125-20-2, Name is Thymolphthalein, belongs to benzofurans compound, is a common compound. Quality Control of ThymolphthaleinIn an article, once mentioned the new application about 125-20-2.

The invention discloses a method for detecting beta – D – glucuronic acid neuraminidase substrate, in particular to hundreds of miles of phenolphthalein – alpha – D – glucuronic acid, its preparation method comprises the following steps: the hundreds of miles of phenolphthalein with acetyl bromide – alpha – D – glucose acid methyl ester by the reaction of the hundreds of miles of phenolphthalein – alpha – acetyl – D – glucuronic acid methyl ester, removing acetyl get hundreds of miles of phenolphthalein – alpha – D – glucuronic acid methyl ester, then the hydrolysis reaction to obtain the hundreds of miles of phenolphthalein – alpha – D – glucuronic acid. The invention hundreds of miles of phenolphthalein – alpha – D – glucuronic acid as a detecting beta – D – glucuronic acid neuraminidase substrate, has stable properties not easy to deteriorate, the advantages of sensitive coloring, and the process is simple, and the cost can be significantly reduced. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4252O – PubChem

90843-31-5, Name is 5-Acetyl-2,3-dihydrobenzo[b]furan, belongs to benzofurans compound, is a common compound. Recommanded Product: 90843-31-5In an article, once mentioned the new application about 90843-31-5.

[Object] It is to provide a novel LXRbeta agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer’s disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C?R7; each X and Y independently show CH2, C=O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2059O – PubChem

Application of 1563-38-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, molecular formula is C10H12O2. In a Article，once mentioned of 1563-38-8

Hydrolytic enzymes constitute one of the largest and most diverse protein classes in Nature and play key roles in nearly all physiological and pathological processes. The mammalian serine hydrolase superfamily contains a remarkable number of uncharacterized members, with at least 40-50% of these enzymes lacking experimentally verified endogenous substrates and products. Assignment of metabolic and cellular functions to these enzymes requires the development of pharmacological tools to selectively perturb their activity. We describe herein a functional proteomic strategy to systematically develop potent and selective inhibitors for uncharacterized serine hydrolases and its application to the brain-enriched enzyme alpha/beta-hydrolase-6. We anticipate that the methods described herein will facilitate the development of selective chemical probes to annotate the metabolic and (patho)physiological functions of many of the uncharacterized serine hydrolases that currently populate eukaryotic and prokaryotic proteomes. Copyright

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1563-38-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2382O – PubChem

64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, belongs to benzofurans compound, is a common compound. HPLC of Formula: C15H10FNOIn an article, once mentioned the new application about 64169-67-1.

The present invention discloses a simple in situ method for the purification of citalopram acid addition salts without isolating crystalline citalopram base as a solid, wherein citalopram base is treated with metal hydrides in solvent medium followed by acid addition, to remove structurally similar impurities by filtration to get crude citalopram acid addition salts. The resulting citalopram salts are subjected to simple purification to get pharmaceutically acceptable acid addition salts. The said citalopram base is prepared by subjecting 5-cyanophthalane to an eco-friendly and safe C-alkylation reaction with 3,N,N dimethylaminopropyl chloride in the presence of strong base in a mixture of dimethylsulfoxide and toluene.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3888O – PubChem

Electric Literature of 127264-14-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran, molecular formula is C10H11BrO. In a Article，once mentioned of 127264-14-6

1,1-Diarylalkanes are important structural frameworks which are widespread in biologically active molecules. Herein, we report a reductive relay cross-coupling of alkyl bromides with aryl bromides by nickel catalysis with a simple nitrogen-containing ligand. This method selectively affords 1,1-diarylalkane derivatives with good to excellent yields and regioselectivity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 127264-14-6. In my other articles, you can also check out more blogs about 127264-14-6

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3838O – PubChem