64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, belongs to benzofurans compound, is a common compound. HPLC of Formula: C15H10FNOIn an article, once mentioned the new application about 64169-67-1.
The present invention discloses a simple in situ method for the purification of citalopram acid addition salts without isolating crystalline citalopram base as a solid, wherein citalopram base is treated with metal hydrides in solvent medium followed by acid addition, to remove structurally similar impurities by filtration to get crude citalopram acid addition salts. The resulting citalopram salts are subjected to simple purification to get pharmaceutically acceptable acid addition salts. The said citalopram base is prepared by subjecting 5-cyanophthalane to an eco-friendly and safe C-alkylation reaction with 3,N,N dimethylaminopropyl chloride in the presence of strong base in a mixture of dimethylsulfoxide and toluene.
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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3888O – PubChem