Category: benzofurans

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate(SMILESS: O=C(OCC)C[C@@H](O)CCl,cas:90866-33-4) is researched.Safety of Methanesulfonato(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)palladium(II). The article 《A method for determining ketoreductase activity in broth》 in relation to this compound, is published in Zhongguo Niangzao. Let’s take a look at the latest research on this compound (cas:90866-33-4).

The UV-Vis spectrophotometer method to determine the enzyme activity in fermentation broth was studied using Et 4-chloroacetoacetate (COBE) as substrate, NAD hydro-phosphate acid (NADPH) as a coenzyme. The enzyme activity was calculated by continuously measuring the consumption of NADPH. The optimum reaction conditions were acquired as follows: NADPH concentration 0.2 mmol/L, COBE 1.0 mmol/L, phosphate buffer 100 mmol/L, pH 6 and temperature 40 °C. Finally, five times parallel detections were done to determine the enzyme activity under the optimum reaction system. It showed that relative standard deviation was 0.48%. This method with advantages of simple, short time-consuming, high accuracy, good repeatability could be generally used in the measurement of ketoreductase activity.

If you want to learn more about this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Safety of (R)-Ethyl 4-chloro-3-hydroxybutanoate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(90866-33-4).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Separation of ethyl (R) 4-chloro-3-hydroxybutyrate from racemic mixture by using bulk liquid membrane.

The separation of optically active Et (R) 4-chloro-3-hydroxybutyrate (CHBE), which is precursor of L-carnitine, from its racemic mixture was studied. Bulk liquid membrane was used as a separation method. Racemic mixture was prepared by mixing each pure enantiomers. Carrier material that facilitates transport of CHBE was dissolved in membrane phase and cinchonidine, cyclodextrin were used as carriers. Carrier concentration, pH gradient, salt addition varied during experiment as exptl. parameters. CHBE transported from feed phase to receiving through the membrane phase, but the enantioselectivity was still in low range. Through whole experiment, proper selection of membrane phase and carrier was key factors that affected CHBE separation

If you want to learn more about this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(90866-33-4).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Rev. Rhumat. called Action of antirheumatic drugs on the rheumatoid arthritic serum factors (hemagglutinating factor, the latex-agglutinating factors 1 and 2, and the streptococcal agglutinating factor), Author is Seifert, H., which mentions a compound: 129-18-0, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2, Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The specific destruction of so-called rheumatoid factor is suggested as the cause of the lowering of the titers of the Waaler-Rose test, the latex-fixation test, and streptococcal-agglutinating test, frequently observed during antirheumatic therapy. The concept of a rheumatoid factor is abandoned in favor of 4 factors isolated from the serum of patients with rheumatoid arthritis: hemagglutinating factor; latex-agglutinating factor LF1; latex agglutinating factor LF2 (which agglutinates only particles of latex pretreated with human γ-globulin); and streptococcal-agglutinating factor. Earlier studies showed that each of these 4 factors consists of an a (agglutinating) fraction and a p (precipitating) fraction. These factors were treated in vitro with antirheumatic drugs for 5 hrs. to demonstrate their lability. The greatest destructive effect was produced by hydrocortisone. Approx. 6-8 mg. sufficed to destroy 1 mg. of factor. Using this procedure, the factor-destroying capacity of known antirheumatic drugs can be determined and other possible agents can be screened. Whether the factor-destroying capacity in each case parallels antirheumatic potency requires further investigation.

If you want to learn more about this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(129-18-0).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yuasa, Yoshifumi; Tsuruta, Haruki published the article 《Practical syntheses of (S)-4-hydroxytetrahydrofuran-2-one, (S)-3-hydroxytetrahydrofuran, and their (R)-enantiomers》. Keywords: hydroxytetrahydrofuranone preparation; hydroxytetrahydrofuran preparation; THF hydroxy preparation; furanol preparation; chlorohydroxybutanoate cyclocondensation kinetics.They researched the compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ).HPLC of Formula: 90866-33-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:90866-33-4) here.

Optically active 4-hydroxytetrahydrofuran-2-one was synthesized in good yield from ClCH2CHOHCH2CO2Et (I) by refluxing with dilute HCl. In a similar manner, optically active 3-hydroxytetrahydrofuran was prepared from ClCH2CHOH(CH2)2OH, which was derived from I by NaBH4-reduction These cyclizations proceed without racemization.

If you want to learn more about this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)HPLC of Formula: 90866-33-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(90866-33-4).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Antagonistic effects against single lethal doses of Amanita phalloides. Author is Floersheim, G. L..

Agents with antagonistic effects against phalloidin [17466-45-4] or α-amanitin [23109-05-9] were tested in mice against lethal doses of an extract from the whole mushroom A. phalloides. The following categories of agents reduced lethality of the extract First, agents protecting only against phalloidin such as rifampicin [13292-46-1], Na phenylbutazone [129-18-0] and antamanide [16898-32-1]. Second, silymarin [22888-70-6] and prednisolone [50-24-8] which display both antiamatoxic and marked (silymarin) or moderate (prednisolone [61-33-6]) antiphallotoxic activity. Thioctic acid [1077-28-7] displayed some activity when tested against mid- lethal doses of the extract Cytochrome c [9007-43-6], a chem. with curative potencies against α-amanitin did not reduce the lethality of the extract All of the effective agents acted only when applied prior to the poisoning. The pattern or protective activity would indicate that in mice death after single doses of A. phalloides may follow a qual. particular course which is difficult to ascribe to phallo- or amatoxic effects alone.

If you want to learn more about this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(129-18-0).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies. Author is Zhu, Dunming; Yang, Yan; Buynak, John D.; Hua, Ling.

In our effort to search for effective carbonyl reductases, the activity and enantioselectivity of a carbonyl reductase from Sporobolomyces salmonicolor have been evaluated toward the reduction of a variety of ketones. This carbonyl reductase (SSCR) reduces a broad spectrum of ketones including aliphatic and aromatic ketones, as well as α- and β-ketoesters. Among these substrates, SSCR shows highest activity for the reduction of α-ketoesters. Aromatic α-ketoesters are reduced to (S)-α-hydroxy esters, while (R)-enantiomers are obtained from the reduction of aliphatic counterparts. This interesting observation is consistent with enzyme-substrate docking studies, which show that hydride transfer occurs at the different faces of carbonyl group for aromatic and aliphatic α-ketoesters. It is worthy to note that sterically bulky ketone substrates, such as 2′-methoxyacetophenone, 1-adamantyl Me ketone, Et 4,4-dimethyl-3-oxopentanoate and Et 3,3-dimethyl-2-oxobutanoate, are reduced to the corresponding alcs. with excellent optical purity. Thus, SSCR possesses an unusually broad substrate specificity and is especially useful for the reduction of ketones with sterically bulky substituents.

If you want to learn more about this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(90866-33-4).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hirschelmann, R.; Bekemeier, Heinz researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.They published the article 《Inhibition of the incorporation of [14C]-leucine into lymphocytes from peritoneal exudate of the rat by cytostatics, antiphlogistics, and selenophenones》 about this compound( cas:129-18-0 ) in Acta Biologica et Medica Germanica. Keywords: lymphocytes peritoneal exudate metabolism; peritoneal exudate lymphocytes metabolism; protein synthesis cytostatics; cytostatics protein synthesis; antiphlogistics protein synthesis; selenophenones protein synthesis; selenium compound protein synthesis. We’ll tell you more about this compound (cas:129-18-0).

Actinomycin C, azathioprine, cyclophosphamide, indomethacin, benzydamine, phenylbutazone, aminophenazone, sodium salicylate, and some new selenophenones (4-alkylseleno-α-alkyl-β-hexamethyleniminophenones) were tested in relation to leucine-14C incorporation into lymphocytes isolated from peritoneal exudate of rats with formaldehyde peritonitis and to depression of the viability of the lymphocytes. It was not possible by these means to discriminate cytostatics from antiphlogistics used in rheumatic diseases. The procedure may be a simple screening test for substances which influence protein synthesis.

If you want to learn more about this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(129-18-0).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthetic Route of C18H20N2O12. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Selective calcium-dependent interaction of calmodulin with the head domain of synapsin 1. Author is Hayes, Nandini V. L.; Bennett, Alison F.; Baines, Anthony J..

The calcium-dependent regulatory protein calmodulin is a critical element in the machinery regulating exocytosis at nerve terminals. T. Okabe and K. Sobue (1987) showed that calmodulin interacts with one of the proteins intimately connected with the neuronal exocytotic process, i.e. synapsin 1. Here, the site at which calmodulin interacts with synapsin 1 was studied. It is possible to generate chem. crosslinked Ca2+-dependent complexes between synapsin 1 and calmodulin in vitro, and covalent crosslinking was used in conjunction with calmodulin affinity chromatog. to identify fragments of synapsin 1 that interact with calmodulin. Ca2+-dependent calmodulin binding is restricted to the head domain (residues 1-453 in bovine synapsin 1). Within this domain the binding site is located in a unique 11-kDa Staphylococcus aureus V8 proteinase-generated fragment. This fragment does not contain the site for cAMP-dependent phosphorylation and therefore does not represent the N terminus of the protein.

If you want to learn more about this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Synthetic Route of C18H20N2O12, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(70539-42-3).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Modification of horseradish peroxidase with bifunctional N-hydroxysuccinimide esters: effects on molecular stability》. Authors are Miland, Enda; Smyth, Malcolm R.; Fagain, Ciaran O..The article about the compound:Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinatecas:70539-42-3,SMILESS:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O).Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. Through the article, more information about this compound (cas:70539-42-3) is conveyed.

Horseradish peroxidase (HRP) has been chem. modified with the homobifunctional crosslinking reagents suberic acid N-hydroxysuccinimide ester (SA-NHS) and ethylene glycol bis-succinimidyl succinate (EG-NHS) yielding derivatives of native HRP with enhanced stability in a range of organic solvents. Modification did not cause any loss of activity. It has been shown that these modification reagents react specifically with the ε-amino groups of the six lysine residues of HRP. Stability increased with concentrations of EG-NHS up to a level of 4-5 mg ml-1. A marked difference was observed in the tryptophan fluorescence profiles of native and the EG-NHS peroxidases upon thermoinactivation at 65°. Both modified peroxidases exhibited improved resistance to the denaturant guanidine hydrochloride.

If you want to learn more about this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(70539-42-3).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, structural characterization, and bonding analysis of two-coordinate copper(I) and silver(I) complexes of pyrrole-based bis(phosphinimine): new metal-pyrrole ring π-interactions, published in 2021, which mentions a compound: 2923-28-6, mainly applied to copper silver pyrrole phosphinimine complex preparation crystal mol structure; electron density aromaticity copper silver pyrrole phosphinimine complex, COA of Formula: CAgF3O3S.

The reaction between 2,5-bis(diphenylphosphinomethyl)pyrrole and Me3SiN3 gave the new pyrrole-based bis(phosphinimine) L1H in an excellent yield. L1H reacts with [CuCl(COD)]2, AgBF4, or AgOTf to give the corresponding two-coordinate mononuclear ionic complex formulated as [M{(L1H)-κ2N,N}]+[X]- where M = Cu and Ag; X = [CuCl2], BF4 or OTf. Their single crystal x-ray diffraction studies confirmed the two-coordinate geometry formed by the chelate bonding mode of L1H. These 10-membered metalacycles exhibit planar chirality and were also characterized by spectroscopic methods. In addition, in all three structures, there exists a hitherto unknown π-interaction between the pyrrole ring atoms and metal, represented as η2-(Cα-N) in the copper(I) complex, and η3-(Cα-N-Cα’) in the silver(I) complexes. These weak interactions were supported by DFT calculations in terms of their electron densities, non-covalent interaction plots and the decrease in the aromaticity of the pyrrole ring.

If you want to learn more about this compound(Silver(I) trifluoromethanesulfonate)COA of Formula: CAgF3O3S, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(2923-28-6).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem