Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Antagonistic effects against single lethal doses of Amanita phalloides. Author is Floersheim, G. L..
Agents with antagonistic effects against phalloidin [17466-45-4] or α-amanitin [23109-05-9] were tested in mice against lethal doses of an extract from the whole mushroom A. phalloides. The following categories of agents reduced lethality of the extract First, agents protecting only against phalloidin such as rifampicin [13292-46-1], Na phenylbutazone [129-18-0] and antamanide [16898-32-1]. Second, silymarin [22888-70-6] and prednisolone [50-24-8] which display both antiamatoxic and marked (silymarin) or moderate (prednisolone [61-33-6]) antiphallotoxic activity. Thioctic acid [1077-28-7] displayed some activity when tested against mid- lethal doses of the extract Cytochrome c [9007-43-6], a chem. with curative potencies against α-amanitin did not reduce the lethality of the extract All of the effective agents acted only when applied prior to the poisoning. The pattern or protective activity would indicate that in mice death after single doses of A. phalloides may follow a qual. particular course which is difficult to ascribe to phallo- or amatoxic effects alone.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem