Category: benzofurans

Liang, Dong-Dong; Guo, Shen-Yi; Tong, Shuo; Wang, Mei-Xiang published an article about the compound: 6-Fluoronicotinonitrile( cas:3939-12-6,SMILESS:N#CC1=CC=C(F)N=C1 ).Reference of 6-Fluoronicotinonitrile. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3939-12-6) through the article.

A practical synthetic method has been developed for polyfunctionalized biaryls e.g., I, e.g., II based on a facile one-pot nucleophilic aromatic substitution (SNAr) reaction and [5,5]- or [3,3]-sigmatropic rearrangement reaction cascade. Under mild basic conditions, N-arylhydroxylamines ArN(R)OH (R = Bn, Me, Boc; Ar = Ph, 6-fluoropyridin-2-yl, 3,5-dichlorophenyl, etc.) reacted with o-activated fluoro (het)arenes R1F (R1 = 2-nitrophenyl, 6-fluoropyridin-2-yl, 4-cyanophenyl, etc.) to form N,O-diarylhydroxylamine intermediates which underwent spontaneously selective [5,5]-sigmatropic rearrangement reaction to produce diverse functionalized 4-amino-4′-hydroxy-1,1′-biaryls e.g., I. A sequential SNAr reaction and [3,3]-sigmatropic rearrangement took place between N-arylhydroxylamines and 2-fluoropyridine derivatives or 4-fluorobenzonitrile to afford functionalized 2-amino-2′-hydroxy-1,1′-biaryls e.g., II. As invaluable and unique building blocks, the resulting biaryls were applied in the straightforward synthesis of N2, O2-coronarene, carbazole, aza- and diaza carbazole derivatives e.g, III.

The article 《Polyfunctionalized biaryls accessed by a one-pot nucleophilic aromatic substitution and sigmatropic rearrangement reaction cascade under mild conditions》 also mentions many details about this compound(3939-12-6)Reference of 6-Fluoronicotinonitrile, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

SDS of cas: 1260795-42-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Methyl 4-bromo-2-formylbenzoate, is researched, Molecular C9H7BrO3, CAS is 1260795-42-3, about Unified Approach to Isoindolinones and THIQs via Lewis Acid Catalyzed Domino Mukaiyama-Mannich Lactamization/Alkylations: Application in the Synthesis of (±)-Homolaudanosine. Author is Dhanasekaran, Sivasankaran; Kayet, Anirban; Suneja, Arun; Bisai, Vishnumaya; Singh, Vinod K..

Isoindolinones such as I (R = H, O2N, NC, Cl, Br, Ph; R1 = Ph, 4-FC6H4, 4-BrC6H4, 4-MeSC6H4, 3,4-Me2C6H3, 3,5-Me2C6H3, PhCH2, H2C:CHCH2) and tetrahydroisoquinolines such as II [R2 = Ph, 3,4-(MeO)2C6H3, 3,4,5-(MeO)3C6H2] were prepared using tandem Mukaiyama-Mannich and lactamization or alkylation reactions from either substituted Me 2-formylbenzoates 5-R-2-OCHC6H3CO2Me (R = H, O2N, NC, Cl, Br, Ph) or 2-(2-bromoethyl)benzaldehydes such as 2-(BrCH2CH2)C6H4CHO, amines such as R1NH2 (R1 = Ph, 4-FC6H4, 4-BrC6H4, 4-MeSC6H4, 3,4-Me2C6H3, 3,5-Me2C6H3, PhCH2, H2C:CHCH2), and silyl enol ethers such as R2C(OSiMe3):CH2 [R2 = Ph, 3,4-(MeO)2C6H3, 3,4,5-(MeO)3C6H2] (III) in the presence of either Zn(OTf)2 or Cu(OTf)2 and TBAF (for I) in CHCl3. Using this method, (±)-homolaudanosine IV was prepared in three steps from III [R2 = 3,4-(MeO)2C6H3], 4,5-(MeO)2-2-(BrCH2CH2)C6H2CHO, and benzylamine. The structure of I (R = H; R1 = 4-BrC6H4) was determined by X-ray crystallog.

The article 《Unified Approach to Isoindolinones and THIQs via Lewis Acid Catalyzed Domino Mukaiyama-Mannich Lactamization/Alkylations: Application in the Synthesis of (±)-Homolaudanosine》 also mentions many details about this compound(1260795-42-3)SDS of cas: 1260795-42-3, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Antacids. II. Gel of aluminum hydroxide》. Authors are Okasaki, Kanzo; Tanabe, Shizuko.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Synthetic Route of C19H19N2NaO2. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The antacidic effectiveness of Al(OH)3 is studied by the modified Fuchs’ method. The efficacy of the spray-dried gel is better than the one dried at low temperature The efficacy decreases in the order liquid gel, dried gel, and granules. Even if dried gel is suspended in water, its efficacy is not improved. The efficacy is related not only to the size of particles, but also to aging. Mech. mixture of dried gel and other antacids, such as Mg salts, did not improve the antacid efficacy, but such mixtures treated with water showed good result.

The article 《Antacids. II. Gel of aluminum hydroxide》 also mentions many details about this compound(129-18-0)Synthetic Route of C19H19N2NaO2, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Self-Assembled Platinum Supramolecular Metallacycles Based on a Novel TADF Photosensitizer for Efficient Cancer Photochemotherapy, published in 2021-03-01, which mentions a compound: 2923-28-6, mainly applied to supramol photosensitizer self assembled organoplatinum metallacycle photochemotherapy; photochemotherapy; photosensitizers; self-assembly; supramolecular coordination complexes, Reference of Silver(I) trifluoromethanesulfonate.

Recently, supramol. coordination complexes (SCCs) based on photosensitizers as bridging ligands have attracted great attention in cancer therapy owing to their synergistic effect between photodynamic therapy (PDT) and chemotherapy. Herein, a highly emissive supramol. platinum triangle BTZPy-Pt based on a novel type of photosensitizer BTZPy with thermally activated delayed fluorescence (TADF) was fabricated. The BTZPy and BTZPy-Pt exhibited strong luminescence emission in the visible range with high quantum yields (quantum yields (QYs) for BTZPy and BTZPy-Pt were about 78 and 62% in ethanol solutions, resp.). Addnl., BTZPy had been proved to be an excellent photosensitizer with superior 1O2 generation capability (the 1O2 generation quantum yield reached up to ca. 95%) for PDT. By the combination of the excellent phototoxicity of BTZPy and the antitumor activity of the Pt center, the platinum triangle BTZPy-Pt demonstrated a highly efficient anticancer performance toward HeLa cells (IC50: 0.5μg mL-1). This study not only provides a blueprint to fabricate new types of photosensitizers but also paves a way to design novel SCCs for efficient PDT.

The article 《Self-Assembled Platinum Supramolecular Metallacycles Based on a Novel TADF Photosensitizer for Efficient Cancer Photochemotherapy》 also mentions many details about this compound(2923-28-6)Reference of Silver(I) trifluoromethanesulfonate, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analysis of mixed preparations. II. Determination of antihistaminics in the mixed preparations》. Authors are Itai, Takanobu; Kamiya, Shozo.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).HPLC of Formula: 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

cf. C.A. 51, 12433f. Antihistaminics, contained in the preparations for colds with various other ingredients, can be determined colorimetrically by precipitation as reineckates. By regulating the pH of their solutions or changing the quantity of added MeOH, the differential determination from other basic ingredients is accomplished. For the determination of antihistaminics in the mixture of aspirin, phenacetin, and caffeine, samples are dissolved in water and the antihistamine is precipitated with 2% NH4 reineckate in MeOH solution In the presence of aminopyrine or antipyrine, Clark-Lubs’ buffer solution is added in order to hold the pH of the solution at 6.5-7.0, then NH4 reineckate is added. The reineckate of ephedrine or methylephedrine is more soluble in MeOH than that of antihistaminics. From preparations containing thiamine, free antihistamine base is extracted with Et2O after adding K2HPO4. The aqueous solution hereby obtained is used for the determination of thiamine as its reineckate. Antihistaminics in the mixture of aspirin, phenacetin, and caffeine are titrated as free bases by passing through a column of Amberlite IR-4B (OH form). As aspirin is adsorbed on the resin, it is eluted with 50% alc. solution of N HCl, and titrated by bromometry.

The article 《Analysis of mixed preparations. II. Determination of antihistaminics in the mixed preparations》 also mentions many details about this compound(129-18-0)HPLC of Formula: 129-18-0, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mansour, Ahmed M.; Radacki, Krzysztof; Shehab, Ola R. published the article 《Role of the ancillary ligand in controlling the lysozyme affinity and electronic properties of terpyridine fac-Re(CO)3 complexes》. Keywords: preparation rhenium terpyridine carbonyl triazolato complex; crystal structure rhenium terpyridine carbonyl triazolato complex; lysozyme binding rhenium terpyridine carbonyl triazolato complex.They researched the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ).Electric Literature of CAgF3O3S. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2923-28-6) here.

The lysozyme binding affinity and the electronic properties of [ReX(CO)3(terpy-κ2N1,N2)] (X = Br- and triazolateCOOCH2CH3,CF3) are reported. The triazolate complex was prepared in a [3+2] cycloaddition click reaction. The bromo compound reacted with lysozyme affording adducts with Re(CO)3+ fragments, while the triazolate compound persisted. A red shift of the MLCT band of the triazolate compound in progressively less polar solvents may be due to the neg. solvatochromism.

The article 《Role of the ancillary ligand in controlling the lysozyme affinity and electronic properties of terpyridine fac-Re(CO)3 complexes》 also mentions many details about this compound(2923-28-6)Electric Literature of CAgF3O3S, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C18H20N2O12. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Thermostabilization of Bacillus amyloliquefaciens α-amylase by chemical crosslinking. Author is Habibi, Azadeh Ebrahim; Khajeh, Khosro; Naderi-Manesh, Hossein; Ranjbar, Bijan; Nemat-Gorgani, Mohsen.

Chem. crosslinking of a mesophilic α-amylase from Bacillus amyloliquefaciens (BAA) was carried out. Intramol. crosslinks between Lys residues upon treatment of the enzyme with ethylene glycol bis(succinic acid N-hydroxy succinimide ester) resulted in enhancement of thermostability as indicated by irreversible thermoinactivation experiments Enhancement of thermostability coincided with a dramatic protection against aggregation, combined with a decrease in surface hydrophobicity. Deamidation, another important mechanism of irreversible thermoinactivation, was also diminished upon modification. While no significant changes in the kinetic parameters were evident, rigidification of the protein structure was suggested by CD and fluorescence studies.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of 6-Fluoronicotinonitrile. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer. Author is Mitch, Charles H.; Quimby, Steven J.; Diaz, Nuria; Pedregal, Concepcion; de la Torre, Marta G.; Jimenez, Alma; Shi, Qing; Canada, Emily J.; Kahl, Steven D.; Statnick, Michael A.; McKinzie, David L.; Benesh, Dana R.; Rash, Karen S.; Barth, Vanessa N..

Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and selectivity for κ opioid receptors. On the basis of receptor binding assays in Chinese hamster ovary (CHO) cells expressing cloned human opioid receptors, (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide (25) had a Ki = 0.565 nM for κ opioid receptor binding while having a Ki = 35.8 nM for μ opioid receptors and a Ki = 211 nM for δ opioid receptor binding. Compound 25 was also a potent antagonist of κ opioid receptors when tested in vitro using a [35S]-guanosine 5’O-[3-thiotriphosphate] ([35S]GTP-γ-S) functional assay in CHO cells expressing cloned human opioid receptors. Compounds were also evaluated for potential use as receptor occupancy tracers. Tracer evaluation was done in vivo, using liquid chromatog.-tandem mass spectrometry (LC/MS/MS) methods, precluding the need for radiolabeling. (S)-3-Chloro-4-(4-((2-(pyridine-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide (18) was found to have favorable properties for a tracer for receptor occupancy, including good specific vs. nonspecific binding and good brain uptake.

After consulting a lot of data, we found that this compound(3939-12-6)Quality Control of 6-Fluoronicotinonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 767291-67-8, is researched, Molecular C20H42N2, about The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand, the main research direction is sparteine chiral catalyst stereoselective alkylation hydrazone.Synthetic Route of C20H42N2.

An asym. alkylation of ketones represents a fundamental transformation in organic chem. Chiral auxiliaries have been used almost exclusively for this transformation. Herein the authors describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83:17, using a chiral ligand protocol. The synthesis of the target compounds was achieved using 3-pentanone 2,2-dimethylhydrazone, 4-heptanone 2,2-dimethylhydrazone, Cycloheptanone 2,2-dimethylhydrazone, benzyl bromide,1-iodopentane, 1-iodohexane, allyl, bromide as starting materials. (7R,7AR,14R,14aS)-dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine [alkaloid, (+)-sparteine] and (7S,7aR,14S,14aS)-dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine [(-)-sparteine] were used as chiral ligands. The title compounds thus formed included (2R)-2-methyl-1-phenyl-3-pentanone, (4S)-4-methyl-3-nonanone, (2R)-2-(2-propen-1-yl)cycloheptanone, (2S)-2-(2-propen-1-yl)cycloheptanone.

After consulting a lot of data, we found that this compound(767291-67-8)Synthetic Route of C20H42N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

SDS of cas: 134434-31-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Isoquinolin-3-ol, is researched, Molecular C9H7NO, CAS is 134434-31-4, about Resonance energies and tautomerism of substituted aromatic heterocycles and their benzo derivatives. Author is Yang, Pipeng; Duan, Wengui.

The recently developed quantified resonance theory (QRT) has been applied to substituted aromatic five- and six-membered heterocycles and their benzo derivatives The calculated resonance energy differences ΔRE between tautomeric forms agree with those estimated from tautomeric equilibrium data for the 2- and 4-pyridone, 2-quinolone and 1-isoquinolone series. For tautomerism of extensive heteroaromatic compounds in solution, the ΔRE and the differences in heats of atomization ΔΔH3 calculated by QRT can be used to rationalize and predict the predominant tautomer and the shifting trend in the equilibrium for a series of similar compounds

After consulting a lot of data, we found that this compound(134434-31-4)SDS of cas: 134434-31-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem