Category: benzofurans

Zeki, K.; Lokmaci, E.; Dogu, Ezgi; Khene, S.; Salih, B.; Canlica, M. published an article in 2021. The article was titled 《Photophysicochemical properties of [Tetrakis 6-(tert-butyl-2,3-dihydrobenzo [b] [1,4] dioxine) phthalocyaninato] In(III) and Zn(II) with very high singlet oxygen quantum yield》, and you may find the article in Inorganica Chimica Acta.Application of 5471-63-6 The information in the text is summarized as follows:

Synthesis and photophysicochem. properties of [tetrakis 6-(tert-butyl-2,3-dihydrobenzo [b] [1,4] dioxine) phthalocyaninato] In(III) (InPc-4) and [tetrakis 6-(tert-butyl-2,3-dihydrobenzo [b] [1,4] dioxine) phthalocyaninato] Zn(II) (ZnPc-5) containing 4-tert-butylcatechol at the peripheral positions are synthesized for application as photosensitizers in photodynamic therapy (PDT). Fluorescence quantum yield, singlet oxygen quantum yield and photodegradation quantum yield were determined for each complex. High singlet oxygen quantum yield of 0.84 and 0.86 (in THF) were obtained for InPc-4 and ZnPc-5, resp. D. functional theory (DFT) and time dependent d. functional theory (TDDFT) were carried out to rationalise the exptl. results. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Hollow ferric-tannic acid nanocapsules with sustained O2 and ROS induction for synergistic tumor therapy》 was written by Zhu, Huimin; Cao, Guodong; Qiang, Chu; Fu, YiKe; Wu, Yulian; Li, Xiang; Han, Gaorong. Product Details of 5471-63-6 And the article was included in Biomaterials Science in 2020. The article conveys some information:

Nanoparticles presenting promoted catalytic activity, oxygen induction and loading capability are in high demand for effective synergistic tumor therapy. Herein, ferric-tannic acid complex nanocapsules with fine hollow microstructure (HFe-TA) are synthesized and loaded with a photosensitizer (indocyanine green, ICG) for synergistic tumor therapy. In acidic environment, ICG@HFe-TA decomposes and releases Fe3+ ions, TA and ICG mols. Fe3+, with low catalytic activity, is effectively converted into highly catalytic Fe2+ by the reductant TA, enabling promoted efficacy of .OH induction. More importantly, the ROS (1O2) induction by ICG is significantly enhanced under 808 nm laser irradiation due to the O2 byproduct of Fe3+/Fe2+ conversion. In consequence, the ICG@HFe-TA nanoparticles exhibit considerable in vitro and in vivo tumor inhibition owing to the combined effect of .OH and 1O2 induced intracellularly. This study has therefore demonstrated a potential platform enabling combined photodynamic and chemodynamic therapy with high efficacy. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Product Details of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Product Details of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kong, Na; Zhang, Hanjie; Feng, Chan; Liu, Chuang; Xiao, Yufen; Zhang, Xingcai; Mei, Lin; Kim, Jong Seung; Tao, Wei; Ji, Xiaoyuan published their research in Nature Communications in 2021. The article was titled 《Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy》.Category: benzofurans The article contains the following contents:

The modulation of intracellular reactive oxygen species (ROS) levels is crucial for cellular homeostasis and determination of cellular fate. A sublethal level of ROS sustains cell proliferation, differentiation and promotes tumor metastasis, while a drastic ROS burst directly induces apoptosis. Herein, surface-oxidized arsenene nanosheets (As/AsxOy NSs) with type II heterojunction are fabricated with efficient ·O2- and 1O2 production and glutathione consumption through prolonging the lifetime of photo-excited electron-hole pairs. Moreover, the portion of AsxOy with oxygen vacancies not only catalyzes a Fenton-like reaction, generating ·OH and O2 from H2O2, but also inactivates main anti-oxidants to cut off the ′′retreat routes′′ of ROS. After polydopamine (PDA) and cancer cell membrane (M) coating, the engineered As/AsxOy@PDA@M NSs serve as an intelligent theranostic platform with active tumor targeting and long-term blood circulation. Given its narrow-band-gap-enabled in vivo fluorescence imaging properties, As/AsxOy@PDA@M NSs could be applied as an imaging-guided non-invasive and real-time nanomedicine for cancer therapy. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Category: benzofurans)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wang, Qi; Cai, Jie; Niu, Xinrui; Wang, Jing; Liu, Jiawei; Xie, Chen; Huang, Wei; Fan, Quli published an article in 2021. The article was titled 《Rational design of high performance nanotheranostics for NIR-II fluorescence/magnetic resonance imaging guided enhanced phototherapy》, and you may find the article in Biomaterials Science.Recommanded Product: 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Nanotheranostics, which can provide great insight into cancer therapy, has been deemed as a promising technol. to settle the unmet medical needs. The rational design of high performance nanotheranostics with multiple complementary imaging features and satisfactory therapeutic efficacy is particularly valuable. Herein, versatile nanotheranostic agents DPPB-Gd-I NPs were fabricated by using gadolinium-diethylenetriaminepentaacetic acid chelates and an iodine-decorated copolymer as encapsulation matrixes to encapsulate a polymer DPPB through one-step nanopptn. We have demonstrated that such nanoagents are able to efficiently damage tumors under single dose injection and NIR laser illumination conditions due to the enhanced photodynamic therapy and enhanced photothermal therapy (the tumor inhibition rate was as high as 94.5%). Moreover, these nanoagents can be utilized as dual-modal NIR-II fluorescence/magnetic resonance imaging probes for tumor diagnosis with high sensitivity, deep tissue penetration, and excellent spatial resolution Overall, this work offers a powerful tactic to fabricate high performance nanotheranostics for clin. application.1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2012,RSC Advances included an article by Song, Wen-Jian; Yang, Xiao-Dong; Zeng, Xiang-Hui; Xu, Xiao-Liang; Zhang, Gao-Lan; Zhang, Hong-Bin. HPLC of Formula: 50551-57-0. The article was titled 《Synthesis and cytotoxic activities of novel hybrid compounds of imidazole scaffold-based 2-substituted benzofurans》. The information in the text is summarized as follows:

A series of novel hybrid compounds between 2-substituted benzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results show that the hybrid compounds were more selective towards an ovarian carcinoma cell line (Skov3-3) and suggest that hybrid compounds bearing 2-substituted benzofuran and benzimidazole moieties, as well as imidazolium salts, were vital for modulating cytotoxic activity. Two 2-substituted benzofuran imidazole hybrids may serve as valuable leads for further structural modifications. The title compounds thus formed included 1-[(2-benzofuranyl)methyl]-3-(phenylmethyl)-1H-benzimidazolium bromide (I) and related substances, such as [(benzofuranyl)methyl]imidazole derivatives The synthesis of the target compounds was achieved by a reaction of imidazole derivatives with 2-benzofuranmethanol. In the experimental materials used by the author, we found Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0HPLC of Formula: 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.HPLC of Formula: 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Erbing, Elis; Sanz-Marco, Amparo; Vazquez-Romero, Ana; Malmberg, Jesper; Johansson, Magnus J.; Gomez-Bengoa, Enrique; Martin-Matute, Belen published an article on February 2 ,2018. The article was titled 《Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations》, and you may find the article in ACS Catalysis.Application In Synthesis of 7-Iodoisobenzofuran-1(3H)-one The information in the text is summarized as follows:

A protocol for the C-H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows the ortho-selective iodination of a variety of benzoic acids under extraordinarily mild conditions in the absence of any additive or base in 1,1,1,3,3,3-hexafluoroisopropanol as the solvent. The iridium catalyst used tolerates air and moisture, and selectively gives ortho-iodobenzoic acids with high conversions. Mechanistic investigations revealed that an Ir(III)/Ir(V) catalytic cycle operates, and that the unique properties of HFIP enables the C-H iodination using the carboxylic moiety as a directing group. After reading the article, we found that the author used 7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0Application In Synthesis of 7-Iodoisobenzofuran-1(3H)-one)

7-Iodoisobenzofuran-1(3H)-one(cas: 105694-46-0) belongs to benzofurans.Application In Synthesis of 7-Iodoisobenzofuran-1(3H)-oneBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Yang, Le; Chua, Xian Wei; Yang, Zhihong; Ding, Xiangpeng; Yu, Yong; Suwardi, Ady; Zhao, Meng; Ke, Karen Lin; Ehrler, Bruno; Di, Dawei published an article in Nanoscale Advances. The title of the article was 《Photon-upconverters for blue organic light-emitting diodes: a low-cost, sky-blue example》.Formula: C20H14O The author mentioned the following in the article:

In the research ecosystem’s quest towards having deployable organic light-emitting diodes with higher-energy emission (e.g., blue light), we advocate focusing on fluorescent emitters, due to their relative stability and color purity, and developing design strategies to significantly improve their efficiencies. We propose that all triplet-triplet annihilation upconversion (TTA-UC) emitters would make good candidates for triplet fusion-enhanced OLEDs (“”FuLEDs””), due to the energetically uphill nature of the photophys. process, and their common requirements. We demonstrate this with the low-cost sky-blue 1,3-diphenylisobenzofuran (DPBF). Having satisfied the criteria for TTA-UC, we show DPBF as a photon upconverter (Ith 92 mW cm-2), and henceforth demonstrate it as a bright emitter for FuLEDs. Notably, the devices achieved 6.5% external quantum efficiency (above the ∼5% threshold without triplet contribution), and triplet-exciton-fusion-generated fluorescence contributes up to 44% of the electroluminescence, as shown by transient measurements. Here, triplet fusion translates to a quantum yield (φ TTA-UC) of 19%, at an elec. excitation of ∼0.01 mW cm-2. The enhancement is meaningful for com. blue OLED displays. We also found DPBF to have decent hole mobilities of ∼0.08 cm2 V-1 s-1. This addnl. finding can lead to DPBF being used in other capacities in various printable electronics. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xiong, Tao; Li, Mingle; Chen, Yingchao; Du, Jianjun; Fan, Jiangli; Peng, Xiaojun published their research in Chemical Science in 2021. The article was titled 《A singlet oxygen self-reporting photosensitizer for cancer phototherapy》.COA of Formula: C20H14O The article contains the following contents:

Photodynamic cancer therapy has attracted great attention with the increasing threat of tumors, and improving its therapeutic efficacy is highly desirable. However, due to the highly efficient intersystem crossing potency to generate singlet oxygen (1O2), high-efficiency photosensitizers often suffer from weak fluorescence and excess injury to normal tissue. To overcome these obstacles, here we show a reliable self-reporting strategy for real-time monitoring of therapeutic progression. As a proof of concept, a mol. dyad is designed by connecting benzo[a]phenoselenazinium (NBSe) to rhodamine (Rh), namely Rh-NBSe, where the fluorescence of the Rh unit is initially suppressed by the fluorescence resonance energy transfer mechanism, but enabled to recover as feedback signal once the reaction with photosensitized 1O2 takes place. The observed fluorescence increases by irradiation in vitro and in vivo successfully reflect the real-time 1O2 generation speed in photodynamic therapy. In addition, the favorable therapeutic advantages of Rh-NBSe are also verified, for example, the high ΦΔ (0.8) and the low IC50 (0.2 μM, 6 J cm-2). Based on the therapeutic ability and real-time 1O2 self-reporting ability, Rh-NBSe demonstrates significant potential for self-regulating phototherapy. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhang, Jiayin; Wang, Qiyu; Hong, Liang; Song, Guoli; Zhang, Zhiguo published an article in 2021. The article was titled 《Optimal fluorescence and photosensitivity properties of dual-functional NaYb1-xF4:Tmx3+ nanoparticles for applications in imaging guided photodynamic therapy》, and you may find the article in RSC Advances.Formula: C20H14O The information in the text is summarized as follows:

The fluorescence and photosensitivity properties of NaYb1-xF4:Tmx3+ nanoparticles were optimized to develop noninvasive near-IR fluorescence imaging-guided photodynamic therapy. The emission at 800 nm from Tm3+ presented an exponential increase with an increase in the Tm3+ doping concentration from 0 to 2%. The photosensitivity properties of NaYb1-xF4:Tmx3+ nanoparticles were also studied via the chemoprobe method, which used a reactive oxygen quencher, 1,3-diphenylisobenzofuran (DPBF). With the increase in the doping concentration of Tm3+, the generation rate of reactive oxygen species in NaYb1-xF4:Tmx3+ nanoparticles decreased linearly at a rate of 0.3. The doping concentration of Tm3+ had two opposite effects on the 800 nm emission and generation rates of reactive oxygen species. The competitive relationship was discussed and an optimal value for the Tm3+ doping concentration of approx. 1% was determined At this concentration, the energy of the Yb3+ excited state can be fully utilized, and the fluorescence and photosensitivity properties are an effective combination. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liu, Ting; Zhang, Honglin; Zhang, Xiyu; Zhao, Hua; Zhang, Zhiguo; Tian, Ye published an article in 2021. The article was titled 《The effect of imidazole on the singlet oxygen quantum yield of sinoporphyrin sodium》, and you may find the article in Chemical Physics.Related Products of 5471-63-6 The information in the text is summarized as follows:

In this paper, the effect of imidazole on the singlet oxygen quantum yield (ΦΔ) of sinoporphyrin sodium (DVDMS) was studied. A relative method was used to measure ΦΔ with Rose Bengal (RB) as the reference and 1,3-diphenylisobenzofuran (DPBF) as the singlet oxygen trapping reagent. It can be found that ΦΔ of DVDMS decreased with the increment of imidazole concentration, and kept 0.33 after the imidazole concentration was above 0.26 M. The process of 1O2 generation and optical properties of DVDMS in different imidazole concentrations were studied to analyze the reason for the above behavior. The invariability of UV-vis absorption and photoluminescence spectra suggested that the reduction of ΦΔ was attributed to the decrease of interaction between DVDMS and O2, which was caused by the surrounding of imidazole on DVDMS. For efficient implementation of PDT, it is necessary to identify the factors that may reduce the effect of PDT. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem