Category: benzofurans

Electric Literature of C20H14OIn 2020 ,《Effective singlet oxygen generation in silica-coated CsPbBr3 quantum dots through energy transfer for photocatalysis》 was published in ChemSusChem. The article was written by Gu, Kailun; Wang, Yu; Shen, Jianhua; Zhu, Jingrun; Zhu, Yihua; Li, Chunzhong. The article contains the following contents:

Here, silica-coated CsPbBr3 quantum dots (QDs) were demonstrated to be effective photosensitizers for the generation of singlet oxygen (1O2). The silica encapsulation improved the stability of the perovskite QDs while also preserving an excellent light-harvesting capability in the visible-light region. The appropriate exciton binding energy and dark exciton generation characteristics of perovskite QDs may be responsible for the energy transfer. The high oxidizability of 1O2 makes the material attractive for application in decomposition of organic dyes such as methyl orange. This work provides new insight for designing excellent perovskite-based photocatalysts. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Electric Literature of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Electric Literature of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sun, Lina; Wang, Xianwen; Gong, Fei; Yin, Kui; Zhu, Wenxiang; Yang, Nailin; Bai, Shang; Liao, Fan; Shao, Mingwang; Cheng, Liang published an article in 2021. The article was titled 《Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy》, and you may find the article in Theranostics.Computed Properties of C20H14O The information in the text is summarized as follows:

Sonodynamic therapy (SDT) triggered by ultrasound (US) can overcome pivotal limitations of photo-therapy owing to its high depth-penetration and low phototoxicity. However, there is still a need to develop more efficient sonosensitizes to enhance the therapy efficiency. In this study, Pt nanoparticles (Pt NPs) are reduced on silicon nanowires (SiNWs) by in situ reduction to prepare Si-Pt nanocomposites (Si-Pt NCs). Si-Pt NCs can produce reactive oxygen radicals (ROS) under ultrasound (US) irradiation, which have sonodynamic therapy (SDT) effect. Meanwhile, Si-Pt NCs can convert excess hydrogen peroxide (H2O2) into ROS in the tumor microenvironment, which endow strong chemodynamic therapy (CDT) effect. Taking the advantages of the mesoporous structure of SiNWs, the SDT and CDT effects of Si-Pt NCs are stronger than those of the pure Pt NPs and SiNWs. Besides, the mild photothermal effect of Si-Pt NCs further improves the SDT & CDT activity and realizes the combined cancer therapy. The developed Si-Pt NCs with the ability of photothermal enhanced SDT/CDT combined therapy play a momentous role in the novel cancer treatment. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Biomineralization-inspired nanozyme for single-wavelength laser activated photothermal-photodynamic synergistic treatment against hypoxic tumors》 was written by Xu, Pengping; Wang, Xueying; Li, Tuanwei; Wu, Huihui; Li, Lingli; Chen, Zhaolin; Zhang, Lei; Guo, Zhen; Chen, Qianwang. SDS of cas: 5471-63-6 And the article was included in Nanoscale in 2020. The article conveys some information:

Hypoxia, one of the features of most solid tumors, can severely impede the efficiency of oxygen-dependent treatments such as chemotherapy, radiotherapy and type-II photodynamic therapy. Herein, a catalase-like nanozyme RuO2@BSA (RB) was first prepared through a biomineralization strategy, and a high efficiency near-IR photosensitizer (IR-808-Br2) was further loaded into the protein shell to generate the safe and versatile RuO2@BSA@IR-808-Br2 (RBIR) for the imaging-guided enhanced phototherapy against hypoxic tumors. RB not only acts like a catalase, but also serves as a photothermal agent that speeds up the oxygen supply under near-IR irradiation (808 nm). The loaded NIR photosensitizer could immediately convert mol. oxygen (O2) to cytotoxic singlet oxygen (1O2) upon the same laser irradiation Results indicated that RBIR achieved enhanced therapeutic outcomes with negligible side effects. Features such as a simple synthetic route and imaging-guided and single-wavelength-excited phototherapy make the nanozyme a promising agent for clin. applications. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wu, Yongzhi; Chen, Fangman; Huang, Nengwen; Li, Jinjin; Wu, Chenzhou; Tan, Bowen; Liu, Yunkun; Li, Longjiang; Yang, Chao; Shao, Dan; Liao, Jinfeng published an article in 2021. The article was titled 《Near-infrared light-responsive hybrid hydrogels for the synergistic chemo-photothermal therapy of oral cancer》, and you may find the article in Nanoscale.Recommanded Product: 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Light-stimulus-responsive therapies have been recognized as a promising strategy for the efficient and safe treatment of oral squamous cell carcinoma (OSCC). Hydrogels have emerged as a promising multifunctional platform combining localized drug delivery and sustained drug release with multimodal properties for combined OSCC therapy. However, inaccurate drug release and limited light-absorption efficiency have hindered their on-demand chemo-photothermal applications. To tackle these problems, an injectable and near-IR (NIR) light-responsive hybrid system was developed by incorporating light-responsive mesoporous silica nanoparticles (MSNs) as doxorubicin (DOX) carriers into the IR820/methylcellulose hydrogel networks for chemophotothermal therapy. Under NIR radiation, the incorporated IR820, a new green cyanine dye, was excited to induce photothermal effects against tumor cells. Meanwhile, MSNs achieved self-degradation-controlled DOX release via the cleavage of diselenide bonds induced by reactive oxygen species. Through the combination of chemotherapy and phototherapy, a long-lasting synergistic anti-tumor effect was achieved in vitro and in vivo with less toxicity. These findings demonstrate the potential of light-responsive hydrogels as a multifunctional platform for accurate synergistic chemophotothermal treatment of OSCC. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Synthesis, spectroscopic characterization and photoactivity of Zr(IV) phthalocyanines functionalized with aminobenzoic acids and their GO-based composites》 was written by Tahershamsi, Leili; Gerasymchuk, Yuriy; Wedzynska, Anna; Ptak, Maciej; Tretyakova, Iryna; Lukowiak, Anna. Computed Properties of C20H14OThis research focused onzirconium phthalocyanine photoactivity aminobenzoic acid graphite oxide composite. The article conveys some information:

Two complexes of bis(aminobenzoato)zirconium(IV) phthalocyanine and their graphite oxide-based composites were synthesized and characterized in respect of their photochem. properties. Structures of phthalocyanines were confirmed by Mass and IR spectroscopies. The absorption and photoluminescence spectra were investigated to show various behavior of the complexes in different media (DMSO and saline). Optical technique (monitoring variation of absorption spectra of diphenylisobenzofuran used as an indicator) was used to prove the generation of reactive oxygen species (ROS) by under light irradiation in the range of the first biol. window. The photoactivity of the materials was compared and discussed in terms of their potential ability to be used in biomedical applications, for example, as photosensitizers in photodynamic therapy. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Photocatalytic coatings based on a zinc(II) phthalocyanine derivative immobilized on nanoporous gold leafs with various pore sizes》 was written by Steinebrunner, David; Schnurpfeil, Guenter; Woehrle, Dieter; Wittstock, Arne. Recommanded Product: 1,3-DiphenylisobenzofuranThis research focused onzinc phthalocyanine nanoporous gold leaf pore size photocatalytic coating. The article conveys some information:

A series of singlet oxygen sensitizing hybrid materials is reported consisting of a zinc(II) phthalocyanine (ZnPc) derivative immobilized on nanoporous gold leafs (npAu) with various pore sizes. The resulting photocatalytic coatings exhibit a thickness of around 100 nm and pore sizes between 9-50 nm. Herein, we report the synthesis and characterization of those hybrid materials which were synthesized by functionalization of npAu leafs by an azide terminated alkanethiol self-assembled monolayer (SAM) and subsequent copper catalyzed azide-alkyne cycloaddition (CuAAC). The characterization of the samples morphol. included SEM (SEM), UV-Vis spectroscopy as well as energy dispersive X-ray spectroscopy (EDX). The morphol.-reactivity relationship was investigated employing the hybrid photocatalysts in the photooxidation of diphenylisobenzofuran (DPBF) as selective singlet oxygen quencher. An increasing photocatalytic activity was found for smaller pore sizes up to 15 nm, due to the gain in sp. surface area concomitant with an increasing amount of immobilized photosensitizer, completely dominating the effect of the higher spectral overlap caused by the shift of the plasmon resonance of npAu, until mass transport and diffusion limitation gets predominant for pore sizes below 15 nm.1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Impact of photosensitizer orientation on the distance dependent photocatalytic activity in zinc phthalocyanine-nanoporous gold hybrid systems》 was written by Steinebrunner, David; Schnurpfeil, Guenter; Kohroede, Mathis; Epp, Alexander; Klangnog, Khaetthariya; Tapia Burgos, Jorge Adrian; Wichmann, Andre; Woehrle, Dieter; Wittstock, Arne. Formula: C20H14OThis research focused onzinc phthalocyanine gold self assembly diphenylisobenzofuran photocatalytic oxidation. The article conveys some information:

Nanoporous gold powder was functionalized in a two-step approach by an azide terminated alkanethiol self-assembled monolayer (SAM) and a zinc(II) phthalocyanine (ZnPc) derivative by copper catalyzed azide-alkyne cycloaddition (CuAAC). A series of different hybrid systems with systematic variation of the alkyl chain length on both positions, the alkanethiol SAM and the peripheral substituents of the ZnPc derivative, was prepared and studied in the photooxidation of diphenylisobenzofuran (DPBF). An enhancement by nearly one order of magnitude was observed for the photosensitized singlet oxygen (1O2) generation of the hybrid systems compared to the same amount of ZnPc in solution caused by the interaction of the npAu surface plasmon resonance and the excited state of the immobilized sensitizer. This interaction was shown to be distance dependent, with decreasing activity for short SAMs with alkyl chain lengths < 6 methylene groups caused by quenching of the excited state via electron transfer as well as decreasing activity for SAMs with n > 8 methylene groups due to decreasing energy transfer for long distances. An unexpected distance dependent behavior was observed for the variation of the peripheral alkyl chain on the photosensitizer revealing a planar orientation of the immobilized photosensitizer on the nanoporous gold surface by a penta-coordinated central zinc ion through interaction with free azide groups from the self-assembled monolayer. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computed Properties of C20H14OIn 2021 ,《Self-Assembled Platinum Supramolecular Metallacycles Based on a Novel TADF Photosensitizer for Efficient Cancer Photochemotherapy》 was published in Molecular Pharmaceutics. The article was written by Lv, Shibo; Miao, Yuyang; Zheng, Daoyuan; Li, Xiaoju; Liu, Dapeng; Song, Fengling. The article contains the following contents:

Recently, supramol. coordination complexes (SCCs) based on photosensitizers as bridging ligands have attracted great attention in cancer therapy owing to their synergistic effect between photodynamic therapy (PDT) and chemotherapy. Herein, a highly emissive supramol. platinum triangle BTZPy-Pt based on a novel type of photosensitizer BTZPy with thermally activated delayed fluorescence (TADF) was fabricated. The BTZPy and BTZPy-Pt exhibited strong luminescence emission in the visible range with high quantum yields (quantum yields (QYs) for BTZPy and BTZPy-Pt were about 78 and 62% in ethanol solutions, resp.). Addnl., BTZPy had been proved to be an excellent photosensitizer with superior 1O2 generation capability (the 1O2 generation quantum yield reached up to ca. 95%) for PDT. By the combination of the excellent phototoxicity of BTZPy and the antitumor activity of the Pt center, the platinum triangle BTZPy-Pt demonstrated a highly efficient anticancer performance toward HeLa cells (IC50: 0.5μg mL-1). This study not only provides a blueprint to fabricate new types of photosensitizers but also paves a way to design novel SCCs for efficient PDT. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Excellent capacity of singlet oxygen generation by gadolinium labelled sinoporphyrin sodium》 was written by Liu, Ting; Zhang, Honglin; Zhao, Hua; Zhang, Zhiguo; Tian, Ye. Computed Properties of C20H14O And the article was included in Journal of Luminescence in 2020. The article conveys some information:

In this paper, we studied the effect of imidazole, a small organic mol. used as a solvent in the synthesis of multifunctional photosensitizers (PSs), on the singlet oxygen quantum yield (ΦΔ) of the PS, gadolinium-containing sinoporphyrin sodium (Gd-DVDMS), using a relative method with Rose Bengal as the reference and 1,3-diphenylisobenzofuran as the singlet oxygen trapping reagent. After completely removal of imidazole by dialysis, the ΦΔ value of Gd-DVDMS was obtained to be as high as 0.97. In addition, with an increase in the imidazole concentration, the ΦΔ of Gd-DVDMS gradually decreased, and stabilized at a value of 0.37. To understand the above phenomenon, the UV-visible absorption and photoluminescence spectra of Gd-DVDMS for different imidazole concentrations were analyzed. The triplet state quantum yield of Gd-DVDMS was constant, while the O2 quenching rate of the triplet state decreased; this indicated that the energy exchange between the PS and O2 was reduced by imidazole. We deduced that decrease in ΦΔ was attributable to the increase in the distance between Gd-DVDMS and O2, owing to imidazole wrapping around Gd-DVDMS. It is speculated that as the wrapping progressed, the effects of the dissolution and attachment of imidazole reached a balance, and hence, the ΦΔ remained constant The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C20H14OIn 2022 ,《Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy》 was published in Bioactive Materials. The article was written by Chang, Meiqi; Feng, Wei; Ding, Li; Zhang, Hongguang; Dong, Caihong; Chen, Yu; Shi, Jianlin. The article contains the following contents:

Tumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy (PDT). Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable an oxygen-boosted PDT, but is limited by scant penetration depth and efficiency of external light. Herein, aiming at the dual purposes of reducing biol. toxicity induced by long-term light irradiation and alleviating hypoxia, we here introduce a novel-designed CaAl2O4:Eu,Nd blue persistent luminescence material (PLM) as the in vivo light source after pre-excited in vitro. The ingenious construction of blue-emitting PLM with “”optical battery”” characteristics activates cyanobacterial cells and verteporfin simultaneously, which performs the successive oxygen supply and singlet oxygen generation without the long-term external excitation, resulting in the modulated tumor hypoxic microenvironment and enhanced photodynamic tumor proliferation inhibition efficiency. Both in vitro cellular assessment and in vivo tumor evaluation results affirm the advantages of self-produced oxygen PDT system and evidence the notable antineoplastic outcome. This work develops an irradiation-free photosynthetic bacteria-based PDT platform for the optimization of both oxygen production capacity and light utilization efficiency in cancer treatment, which is expected to promote the clin. progress of microbial-based photonic therapy. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem