Wu, Jiang et al. published their research in Chemical Science in 2016 |CAS: 60770-67-4

The Article related to aryl halide diisopropylphenylimidazolidinyl difluoromethylthiosilver palladium catalyst difluoromethylthiolation, heteroaryl triflate diisopropylphenylimidazolidinyl difluoromethylthiosilver palladium catalyst difluoromethylthiolation and other aspects.Product Details of 60770-67-4

Wu, Jiang; Liu, Yafei; Lu, Changhui; Shen, Qilong published an article in 2016, the title of the article was Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides.Product Details of 60770-67-4 And the article contains the following content:

Palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described. A vast range of heteroaryl halides such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl and pyrazolyl halides could be difluoromethylthiolated efficiently, thus providing medicinal chemists with new tools for their search of new led compounds for drug discovery. Likewise, aryl iodides were difluoromethylthiolated in high yields under a modified reaction condition. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Product Details of 60770-67-4

The Article related to aryl halide diisopropylphenylimidazolidinyl difluoromethylthiosilver palladium catalyst difluoromethylthiolation, heteroaryl triflate diisopropylphenylimidazolidinyl difluoromethylthiosilver palladium catalyst difluoromethylthiolation and other aspects.Product Details of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Huang, Mingming et al. published their research in Chemistry – A European Journal in 2021 |CAS: 60770-67-4

The Article related to crystal structure mol nickel heterocyclic carbene preparation optimized dft, nickel catalyzed borylation aryl sulfoxide regioselective substituent steric effect, boron, n-heterocyclic carbenes, borylation, cross-coupling, nickel and other aspects.Application of 60770-67-4

On June 1, 2021, Huang, Mingming; Wu, Zhu; Krebs, Johannes; Friedrich, Alexandra; Luo, Xiaoling; Westcott, Stephen A.; Radius, Udo; Marder, Todd B. published an article.Application of 60770-67-4 The title of the article was Ni-Catalyzed Borylation of Aryl Sulfoxides. And the article contained the following:

A nickel/N-heterocyclic carbene (NHC) catalytic system has been developed for the borylation of aryl sulfoxides with B2(neop)2 (neop=neopentyl glycolato). A wide range of aryl sulfoxides with different electronic and steric properties were converted into the corresponding arylboronic esters in good yields. The regioselective borylation of unsym. diaryl sulfoxides was also feasible leading to borylation of the sterically less encumbered aryl substituent. Competition experiments demonstrated that an electron-deficient aryl moiety reacts preferentially. The origin of the selectivity in the Ni-catalyzed borylation of electronically biased unsym. diaryl sulfoxide lies in the oxidative addition step of the catalytic cycle, as oxidative addition of methoxyphenyl 4-(trifluoromethyl)phenyl sulfoxide to the Ni(0) complex occurs selectively to give the structurally characterized complex trans-[Ni(ICy)2(4-CF3-C6H4){(SO)-4-MeO-C6H4}] 4. For complex 5, the isomer trans-[Ni(ICy)2(C6H5)(OSC6H5)] 5-i was structurally characterized in which the Ph sulfinyl ligand is bound via the oxygen atom to nickel. In solution, the complex trans-[Ni(ICy)2(C6H5)(OSC6H5)] 5-i is in equilibrium with the S-bonded isomer trans-[Ni(ICy)2(C6H5)(SOC6H5)] 5, as shown by NMR spectroscopy. DFT calculations reveal that these isomers are separated by a mere 0.3 kJ/mol (M06/def2-TZVP-level of theory) and connected via a transition state trans-[Ni(ICy)2(C6H5)(η2-{SO}-C6H5)], which lies only 10.8 kcal/mol above 5. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4

The Article related to crystal structure mol nickel heterocyclic carbene preparation optimized dft, nickel catalyzed borylation aryl sulfoxide regioselective substituent steric effect, boron, n-heterocyclic carbenes, borylation, cross-coupling, nickel and other aspects.Application of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yang, Wenjun et al. published their research in Angewandte Chemie, International Edition in 2020 |CAS: 60770-67-4

The Article related to synergistic nitrogen heterocyclic carbene palladium catalyzed umpolung addition, diaryl propanoate preparation addition aryl iodide enal, n-heterocyclic carbenes, addition reactions, cooperative catalysis, palladium, umpolung and other aspects.Related Products of 60770-67-4

Yang, Wenjun; Ling, Bo; Hu, Bowen; Yin, Haolin; Mao, Jianyou; Walsh, Patrick J. published an article in 2020, the title of the article was Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Aryl Iodides to Enals.Related Products of 60770-67-4 And the article contains the following content:

An umpolung 1,4-addition of aryl iodides to enals promoted by cooperative (terpy)Pd/NHC catalysis was developed that generates various bioactive β,β-diaryl propanoate derivatives This system is not only the first reported palladium-catalyzed arylation of NHC-bound homoenolates but also expands the scope of NHC-induced umpolung transformations. A diverse array of functional groups such as esters, nitriles, alcs., and heterocycles are tolerated under the mild conditions. This method also circumvents the use of moisture-sensitive organometallic reagents. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Related Products of 60770-67-4

The Article related to synergistic nitrogen heterocyclic carbene palladium catalyzed umpolung addition, diaryl propanoate preparation addition aryl iodide enal, n-heterocyclic carbenes, addition reactions, cooperative catalysis, palladium, umpolung and other aspects.Related Products of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fritzemeier, Russell G. et al. published their research in Angewandte Chemie, International Edition in 2020 |CAS: 60770-67-4

The Article related to organocatalytic stereoselective phosphinoboration internal alkyne regioselective, crystal structure mol phosphino boryl acrylate trans preparation, alkynes, boron, organocatalysis, phosphinoboration, phosphorus and other aspects.SDS of cas: 60770-67-4

On August 10, 2020, Fritzemeier, Russell G.; Nekvinda, Jan; Vogels, Christopher M.; Rosenblum, Carol Ann; Slebodnick, Carla; Westcott, Stephen A.; Santos, Webster L. published an article.SDS of cas: 60770-67-4 The title of the article was Organocatalytic trans Phosphinoboration of Internal Alkynes. And the article contained the following:

We report the first trans phosphinoboration of internal alkynes. With an organophosphine catalyst, alkynoate esters and the phosphinoboronate Ph2P-Bpin are efficiently converted into the corresponding trans-α-phosphino-β-boryl acrylate products in moderate to good yield with high regio- and Z-selectivity. This reaction operates under mild conditions and demonstrates good atom economy, requiring only a modest excess of the phosphinoboronate. X-ray crystallog. experiments allowed structural assignment of the unprecedented and densely functionalized (Z)-α-phosphino-β-boryl acrylate products. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).SDS of cas: 60770-67-4

The Article related to organocatalytic stereoselective phosphinoboration internal alkyne regioselective, crystal structure mol phosphino boryl acrylate trans preparation, alkynes, boron, organocatalysis, phosphinoboration, phosphorus and other aspects.SDS of cas: 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liu, Yong et al. published their research in Organic Chemistry Frontiers in 2022 |CAS: 60770-67-4

The Article related to organic iodide thiosulfonate nickel catalyst chemoselective reductive coupling, thioether preparation, selenosulfonate organic iodide nickel catalyst chemoselective reductive coupling, selenoether preparation and other aspects.Formula: C8H5IO

Liu, Yong; Xing, Shuya; Zhang, Jing; Liu, Wen; Xu, Yuenian; Zhang, Yan; Yang, Kefang; Yang, Lei; Jiang, Kezhi; Shao, Xinxin published an article in 2022, the title of the article was Construction of diverse C-S/C-Se bonds via nickel catalyzed reductive coupling employing thiosulfonates and a selenosulfonate under mild conditions.Formula: C8H5IO And the article contains the following content:

A nickel-catalyzed reductive cross coupling between organic iodides and thiosulfonates and a selenosulfonate under mild conditions was disclosed. This practical method provides a facile access to a series of unsym. thioethers with low catalyst loading, good functional group tolerance, and excellent chemo-selectivity. Notably, the synthetic applications of the approach feature scaling-up of reactions, late-stage modification of pharmaceuticals, and preparation of various useful targeted compounds, including sulfoximine, bipyridine, and vortioxetine. Primary mechanistic studies showed that a radical pathway was involved. Moreover, diverse C-S/C-Se bond formations were achieved under mild reaction conditions. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Formula: C8H5IO

The Article related to organic iodide thiosulfonate nickel catalyst chemoselective reductive coupling, thioether preparation, selenosulfonate organic iodide nickel catalyst chemoselective reductive coupling, selenoether preparation and other aspects.Formula: C8H5IO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Bowen, Johnathan et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2022 |CAS: 60770-67-4

The Article related to unsaturated nitrile borylated cyanovinyl borate preparation organocatalytic hydroboration propiolonitrile, phosphine organocatalyst hydroboration propiolonitrile preparation vinylborate nitrile derivative and other aspects.Safety of 5-Iodobenzofuran

Bowen, Johnathan; Slebodnick, Carla; Santos, Webster L. published an article in 2022, the title of the article was Phosphine-catalyzed hydroboration of propiolonitriles: access to (E)-1,2-vinylcyanotrifluoroborate derivatives.Safety of 5-Iodobenzofuran And the article contains the following content:

We report an organocatalytic trans-hydroboration of 3-substituted-propiolonitriles. In the presence of catalytic amounts of tributylphosphine and pinacolborane, regioselective hydroboration of the internal triple bond proceeded in a stereoselective fashion under mild conditions to afford the corresponding (E)-1,2-vinylcyanoborane derivatives The mechanism is proposed to occur through a 1,2-phosphine addition instead of a canonical 1,4-conjugate addition pathway. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Safety of 5-Iodobenzofuran

The Article related to unsaturated nitrile borylated cyanovinyl borate preparation organocatalytic hydroboration propiolonitrile, phosphine organocatalyst hydroboration propiolonitrile preparation vinylborate nitrile derivative and other aspects.Safety of 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gao, Mengyu et al. published their research in Organic Letters in 2019 |CAS: 60770-67-4

The Article related to synthesis aryl ester reductive cross coupling oxalate aryl halide, aryl ester preparation arylation aryl halide oxalate radical fragmentation, oxalate radical fragmentation reduction potential and other aspects.Quality Control of 5-Iodobenzofuran

On March 15, 2019, Gao, Mengyu; Sun, Deli; Gong, Hegui published an article.Quality Control of 5-Iodobenzofuran The title of the article was Ni-Catalyzed Reductive C-O Bond Arylation of Oxalates Derived from α-Hydroxy Esters with Aryl Halides. And the article contained the following:

A Ni-catalyzed reductive cross-coupling of α-hydroxycarbonyl compounds modified with oxalyl groups and aryl halides has been developed that furnishes α-aryl esters under mild conditions and tolerates a variety of functionalized aryl halides bearing electron-withdrawing and -donating groups. This work highlights C-O bond fragmentation on secondary alkyl carbon centers that generates α-carbonyl radicals. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Quality Control of 5-Iodobenzofuran

The Article related to synthesis aryl ester reductive cross coupling oxalate aryl halide, aryl ester preparation arylation aryl halide oxalate radical fragmentation, oxalate radical fragmentation reduction potential and other aspects.Quality Control of 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wang, Shuxiang et al. published their research in Bioorganic & Medicinal Chemistry in 2018 |CAS: 53724-96-2

The Article related to benzofuran synthesis antitumor mnk kinase leukemia, 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives, anti-proliferative effects, fragment-based drug design, mnks inhibitors and other aspects.COA of Formula: C13H14O4

On September 1, 2018, Wang, Shuxiang; Li, Bo; Liu, Bo; Huang, Min; Li, Deyi; Guan, Lihong; Zang, Jie; Liu, Dan; Zhao, Linxiang published an article.COA of Formula: C13H14O4 The title of the article was Design and synthesis of novel 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives as potent Mnks inhibitors by fragment-based drug design. And the article contained the following:

A novel series of 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives featured with various C-2 substituents were designed and synthesized as Mnks inhibitors through fragment-based drug design. Among them, 5b, 5i, 5o and 8k showed the best Mnk2 inhibitory activity with IC50 values of 1.45, 1.16, 3.55 and 0.27 μM, resp. And these compounds inhibited the activity of Mnk1 at the same time. Furthermore, compounds 5o and 8k exhibited anti-proliferative effects to human leukemia cancer THP-1 and MOLM-13 cell lines and colon cancer HCT-116 cell line. Moreover, Western blot assay suggested that 8k could decrease the levels of p-eIF4E in a dose-dependent manner in HCT-116 cells. Docking studies demonstrated strong interactions between 8k and Mnk2. Therefore, this unique benzofuran scaffold demonstrated great potential to be further explored as potent Mnks inhibitors with improved potency. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).COA of Formula: C13H14O4

The Article related to benzofuran synthesis antitumor mnk kinase leukemia, 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives, anti-proliferative effects, fragment-based drug design, mnks inhibitors and other aspects.COA of Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kusy, Rafal et al. published their research in ChemRxiv in 2021 |CAS: 60770-67-4

The Article related to ferrocenyl diphosphine iridium catalyzed stereoselective chemoselective transfer semihydrogenation alkyne, crystal mol structure ferrocenyl diphosphine iridium cyclooctadiene complex and other aspects.Product Details of 60770-67-4

Kusy, Rafal; Lindner, Marcin; Wagner, Jakub; Grela, Karol published an article in 2021, the title of the article was Highly functional group tolerant, (E)-selective transfer semihydrogenation of alkynes catalyzed by iridium complex bearing unsymmetrical ferrocene-based phosphine ligand.Product Details of 60770-67-4 And the article contains the following content:

Herein, authors present (E)-selective transfer semihydrogenation of alkynes based on in situ generated iridium complex from [Ir(COD)Cl]2 and unsym. ferrocene-based phosphine ligand in the presence of formic acid as a hydrogen donor. The catalytic system is distinguished by unprecedented chemoselectivity and exceptional stereoselectivity substantiated by the broad scope of tested substrates, including natural products derivatives The uniform reaction conditions may be applied to various alkynes, owing to a lack of over-reduction The intriguing difference in catalytic activity between unsym. and sym. ferrocene-based ligands was attributed to divergent coordination and steric hindrance. The presented methodol. constitutes a solution to the common limitations of the published catalytic systems. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Product Details of 60770-67-4

The Article related to ferrocenyl diphosphine iridium catalyzed stereoselective chemoselective transfer semihydrogenation alkyne, crystal mol structure ferrocenyl diphosphine iridium cyclooctadiene complex and other aspects.Product Details of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhang, Yan et al. published their research in Organic Letters in 2022 |CAS: 60770-67-4

The Article related to structure reactivity trideuteromethylthiolation trideuteromethyl arylsulfonothioate, trideuteromethyl arylsulfonothioate preparation methylthiolation nucleophile electrophile and other aspects.Electric Literature of 60770-67-4

On September 23, 2022, Zhang, Yan; Liu, Wen; Xu, Yuenian; Liu, Yong; Peng, Jiajian; Wang, Minyan; Bai, Ying; Lu, Hua; Shi, Zhuangzhi; Shao, Xinxin published an article.Electric Literature of 60770-67-4 The title of the article was S-(Methyl-d3) Arylsulfonothioates: A Family of Robust, Shelf-stable, and Easily Scalable Reagents for Direct Trideuteromethylthiolation. And the article contained the following:

A family of electrophilic deuterated methylthiolating reagents, S-(Methyl-d3) arylsulfonothioates, was developed in two or three steps from cheap d4-MeOH in high yields. S-(Methyl-d3) arylsulfonothioates represent a kind of powerful deuterated methylthiolating reagent and allow modular (trideuteromethyl)thiolation with a variety of nucleophiles or electrophiles including aryl(hetero) iodides, boronic acids esters, terminal alkynes, β-ketoester, and oxindole under mild reaction conditions. A structure-reactivity research study was conducted and provided a new avenue for the development of deuterated methylthiolating reagents and efficient methodol. for (trideuteromethyl)thiolation. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Electric Literature of 60770-67-4

The Article related to structure reactivity trideuteromethylthiolation trideuteromethyl arylsulfonothioate, trideuteromethyl arylsulfonothioate preparation methylthiolation nucleophile electrophile and other aspects.Electric Literature of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem