Category: benzofurans

Chen, Wei; Zhou, Zhao-Hui; Chen, Hong-Bin published an article in 2017, the title of the article was Efficient synthesis of chiral benzofuryl β-nitro alcohols via a catalytic asymmetric Henry reaction.Formula: C13H14O4 And the article contains the following content:

Chiral β-amino alc. ligands were found to be effective for the copper(II)-catalyzed asym. Henry reaction of benzofuran-2-carboxaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl β-nitro alcs. with satisfactory enantioselectivities (up to 98% ee). The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Formula: C13H14O4

The Article related to benzofuran carboxaldehyde nitromethane copper acetate catalyst enantioselective henry reaction, benzofuryl nitro ethanol preparation, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rene, Loic; Buisson, Jean P.; Royer, Rene published an article in 1975, the title of the article was Reactions induced by pyridinium halides. XX. First examples of dealkylation by pyridinium hydrochloride in quinoline.Formula: C13H14O4 And the article contains the following content:

Benzofuranols I-VI (R = R1 = H, R2 = H, Me) were prepared in improved yields by demethylating I-VI (R1 = Me) with pyridine-HCl in quinoline. I-VI (R1 = Me) were prepared by formylating coumarilic acid esters, hydrolyzing I-VI (R = CO2Me, CO2Et, R1 = Me), and decarboxylating I-VI (R = CO2H). The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Formula: C13H14O4

The Article related to benzofuranol formyl, demethylation methoxybenzofuran pyridine hydrochloride, quinoline demethylation solvent, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 31, 1990, Suzuki, Tsuneo published an article.Computed Properties of 53724-96-2 The title of the article was The reaction of ethyl (2-acetyl-5-methoxyphenoxy)acetate with potassium hydroxide. And the article contained the following:

The reaction of title ester I (R = Et) with KOH gave benzofurans, benzoxepindione II, and I (R = H). The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Computed Properties of 53724-96-2

The Article related to acetylphenoxyacetate cyclization hydroxide, benzofuran derivative, benzoxepindione derivative, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Computed Properties of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cagniant, Paul; Kirsch, Gilbert published an article in 1976, the title of the article was Method for the synthesis of mono- or polysubstituted 3(2H)-benzofuranones and benzo[b]furans.Name: 5-Iodobenzofuran And the article contains the following content:

Benzofurans I (R = H, Me; R1 = 7-Me, 6-Me, 6-OMe, 5-OMe, 5-SMe, 5-F, 5-I; R2 = H) were prepared by alkylating the salicyclic esters II (R3 = H) with BrCHRCO2Et, hydrolyzing II (R3 = CHRCO2Et), cyclizing the diacids with AcONa-AcOH-Ac2O, hydrolyzing I (R2 = OAc), reducing III (X =O), and dehydrating III (X = H,OH). I (R = Ac, R2 = OAc) were obtained as byproducts of I (R = H,Me, R2 = OAc). The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to benzofuran, salicylate carboxyalkoxy cyclization, carboxyalkoxysalicyclate cyclization, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On July 1, 2007, Salih, Kifah S. M.; Ayoub, Mikdad T.; Saadeh, Haythem A.; Al-Masoudi, Najim A.; Mubarak, Mohammad S. published an article.COA of Formula: C13H14O4 The title of the article was Synthesis, characterization, and biological activities of new benzofuran derivatives. And the article contained the following:

New benzofuran derivatives, Et 3-[(alkylamino)methyl]-6-methoxy-1-benzofuran-2-carboxylates, e.g., I, were obtained via the reaction between Et 3-(bromomethyl)-6-methoxy-1-benzofuran-2-carboxylate (II) and amines or amino acid Et esters. In addition, 1,4-bis[(Et 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]piperazine, N,N’-diethyl-N,N’-bis[(6-methoxy-1-benzofuran-3-yl-2-carboxylate) methyl]but-2-ene-1,4-diamine, and 1,2-bis[(Et 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]-1,2-dimethylhydrazine were also obtained from the reaction of II with diamines. Their in vitro anti-HIV-1 (strain IIIB) and HIV-2 (strain ROD) activities of the synthesized compounds in human T-lymphocyte were tested; II displayed an ability to inhibit HIV-1 and HIV-2 replication in cell culture at non-toxic concentrations The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).COA of Formula: C13H14O4

The Article related to benzofurancarboxylate derivative preparation antihiv activity, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.COA of Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 31, 1991, Suzuki, Tsuneo published an article.Electric Literature of 53724-96-2 The title of the article was The reaction of ethyl 2-acetyl-5-methoxyphenoxyacetate with some bases in various solvents. And the article contained the following:

The reaction of the title compound (I) with KOH, NaOH, KOCMe3, EtONa, NaH, or NaNH2 in dioxane, THF, DMF, Me2SO, MeOH, EtOH, or Me3COH was reported. E.g., reaction of I with KOH in dioxane gave 19% benzofuran II, 44% benzofuran III, and 25% benzoxepin III. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Electric Literature of 53724-96-2

The Article related to acetylmethoxyphenoxyacetate cyclization solvent effect, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Electric Literature of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 3, 2005, Cheng, Jie Fei; Nguyen, Bao Ngoc; Liu, Xuewei; Lopaschuk, Gary D.; Dyck, Jason R. published a patent.Product Details of 29735-85-1 The title of the patent was Preparation of heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors. And the patent contained the following:

The present invention provides methods for the use of compounds I [X1, X2, X3 = O, N, NH, NR5, S, C; R1, R2 = H, halogen, substituted C1-6-alkyl, substituted C1-6-alkenyl, substituted C1-6-alkynyl, alkoxy, (un)substituted Ph, aryl, (un)substituted heteroaryl, NHCONR5R6, COR5, CONR5R6, S(O)nR5, SO2NR5R6; R3, R4 = H, Br, Cl, F, I, OH, OMe, CO2H, CO2R5, CONR5R6, S(O)nR5, SO2NR5R6, substituted C1-6-alkyl, C1-6-alkoxy, (un)substituted Ph, aryl, heteroaryl; R5, R6 = H, (un)substituted C1-6-alkyl, (un)substituted Ph, aryl, heteroaryl], its enantiomers, diastereomers, tautomers, or physiol. acceptable salts or prodrugs, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. Thus, benzofuran I [X1 = CC(:O)NHC6H3(OMe)2-3,4, X2 = CH, X3 = O, R3 = 4-Br, R4 = 6-Br] was prepared from 5-methoxybenzofuran-2-carboxylic acid via regioselective bromination at C(3), decarboxylation, debromination-carboxylation at C(3), O-demethylation, regioselective dibromination and amidation with 3,4-dimethoxyaniline. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. The inhibitory activity of I vs. malonyl-CoA decarboxylase was determined [Ki = 31.6 – 4750.2 μM]. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity. The experimental process involved the reaction of 5-Hydroxybenzofuran-3-carboxylic acid(cas: 29735-85-1).Product Details of 29735-85-1

The Article related to heterocyclic compound preparation malonyl coa decarboxylase inhibitor, cardiovascular disease prophylaxis management treatment heterocyclic compound, diabetes prophylaxis management treatment heterocyclic compound, cancer prophylaxis management treatment heterocyclic compound, obesity prophylaxis management treatment heterocyclic compound and other aspects.Product Details of 29735-85-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 31, 2021, Wu, Xiaowei; Dai, Mengdi; Cui, Rongrong; Wang, Yulan; Li, Chunpu; Peng, Xia; Zhao, Jihui; Wang, Bao; Dai, Yang; Feng, Dan; Yang, Tianbiao; Jiang, Hualiang; Geng, Meiyu; Ai, Jing; Zheng, Mingyue; Liu, Hong published an article.Synthetic Route of 53724-96-2 The title of the article was Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors. And the article contained the following:

Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy. In this study, we synthesized and evaluated the biol. activity of 66 pyrazolo[3,4-d]pyridazinone derivatives Kinase inhibition, cell proliferation, and whole blood stability assays were used to evaluate their activity on FGFR, allowing us to explore structure-activity relationships and thus to gain understanding of the structural requirements to modulate covalent inhibitors′ selectivity and reactivity. Among them, compound 10h exhibited potent enzymic activity against FGFR and remarkably inhibited proliferation of various cancer cells associated with FGFR dysregulation, and suppressed FGFR signaling pathway in cancer cells by the immunoblot anal. Moreover, 10h displayed highly potent antitumor efficacy (TGI = 91.6%, at a dose of 50 mg/kg) in the FGFR1-amplified NCI-H1581 xenograft model. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Synthetic Route of 53724-96-2

The Article related to pyrazolo pyridazinone derivative covalent fgfr inhibitor biol evaluation, pyridazinone derivative covalent fgfr inhibitor biol evaluation sar, antitumor efficacy, btk, brutons tyrosine kinase, cadd, computer-aided drug design, covalent fgfr inhibitors, egfr, epidermal growth factor receptor and other aspects.Synthetic Route of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On September 16, 2022, Chen, Doris; Jones, Elizabeth V.; Williams, Corey W.; Huynh, Tan-Khang N.; McPhail, Tristan C.; France, Stefan published an article.Recommanded Product: 5-Iodobenzofuran The title of the article was Intramolecular, Interrupted Homo-Nazarov Cascade Biscyclizations to Angular (Hetero)Aryl-Fused Polycycles. And the article contained the following:

A SnCl4-catalyzed intramol., interrupted homo-Nazarov cascade biscyclization to access angular (hetero)aryl-fused polycycles was reported. Subsequent decarboxylation of the readily enolizable products afforded the angular products in up to 71% yield over two steps, with the trans-diastereomers as the major products. The cyclopropyl homo-Nazarov cyclization precursors were formed using a scalable and modular synthetic route that, ultimately, offers access to 6,6,6-, 6,6,5-, 6,5,6-, 6,6,5,6-, and 6,6,6,5-fused angular polycyclic products. To showcase the rigor and utility of the method, an 8-step total synthesis of (±)-1-oxoferruginol, an antibacterial aromatic abietane diterpenoid, was disclosed. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Recommanded Product: 5-Iodobenzofuran

The Article related to alkenyl cyclopropyl ketone tin chloride homo nazarov biscyclization decarboxylation, angular polycyclic compound preparation diastereoselective, cation-pi cyclizations, domino reactions, donor-acceptor cyclopropanes, oxyallyl cations, ring-opening cyclizations and other aspects.Recommanded Product: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 22, 2012, Smith, Nicholas D.; Kahraman, Mehmet; Govek, Steven P.; Nagasawa, Johnny Y.; Lai, Andiliy G.; Julien, Jackaline D.; Herbert, Mark R.; Bonnefous, Celine; Douglas, Karensa L. published a patent.Computed Properties of 60770-67-4 The title of the patent was Preparation of substituted 3-[4-[1-(1H-indazol-5-yl)-2-phenylvinyl]phenyl]acrylic acid, derivatives and analogs as estrogen receptor modulators. And the patent contained the following:

The invention is related to the preparation of title compounds I [A =indanyl, indenyl, 8-10 membered bicyclic hetercyclic, etc.; B, C = independently Ph, naphthyl, 5-6 membered monocyclic heteroaryl, etc.; R1 = tetrazolyl, pyrrolidinyl, aminocycloalkyl, etc.; R2 = halo, CN, nO2, alkoxy, etc.; R3-4 = independently at each occurrence H, CN, OH, (un)substituted fluoroalkyl, Ph, etc; m, n, p = independently 0-4], their pharmaceutically acceptable salts and N-oxides as estrogen receptor modulators and to pharmaceutical compositions containing them. Thus, (E)-3-[4-[(E)-1-(1H-Indazol-5-yl)-2-phenylbut-1-en-1-yl]phenyl]-2-propenoic acid (II) was prepared via reaction of 5-(1-butyn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (preparation given) with iodobenzene and (E)-[4-(3-ethoxy-3-oxoprop-1-en-1-yl)phenyl]boronic acid. II displayed an IC50 ≤ 100 nM in the MCF7 viability assay. I may be useful for the treatment of diseases or conditions that are mediated by or dependent upon estrogen receptors such as cancer, central nervous system (CNS) defects, cardiovascular system defects, hematol. system defects, immune and inflammation diseases, susceptibility to infection, metabolic defects, neurol. defects, psychiatric defects and reproductive defects. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Computed Properties of 60770-67-4

The Article related to indazolyl phenylvinylphenylacrylic acid preparation estrogen receptor modulator cancer cardiovascular, quinoxalinyl benzothiazolyl indazolyl triazolopyridinyl oxoisoindolinyl phenylvinylphenylacrylic acid phenylvinylphenylacrylamide preparation and other aspects.Computed Properties of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem