Category: benzofuran

123654-26-2, 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 4-amino-5-chloro-2,3-dihydro benzofuran-7-carboxylic acid (Chem. Pharm. Bull. 1998, 46{), 42-52; 3.93 g, 18.4 mmol) in methanol (36.8 mL), cooled at 0 C, thionyl chloride (6.0 mL) was added. The reaction mixture was gradually warmed to room temperature and was heated to reflux for 2 hours. The volatiles were removed under reduced pressure; the crude mass was diluted with aqueous sodium bicarbonate solution and was extracted with ethyl acetate. The combined organic layer was dried over anhydrous sodium sulphate and the solvent was removed under vacuum to obtain methyl 4-amino-5-chloro-2,3-dihydro benzofuran-7-carboxylate (3.89 grams). Yield: 92.9 % ? – NMR (DMSO-de): delta 7.43 (s, 1H), 6.06 (bs, 2H), 4.60 (t, J = 8.8 Hz, 2H), 3.68 (s, 3H), 2.97 (t, J = 8.8 Hz, 2H); Mass (m/z): 228.0, 230.1 (M+H)+.

123654-26-2, The synthetic route of 123654-26-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; MOHAMMED, Abdul Rasheed; YARLGADDA, Suresh; RAVELLA, Srinivasa Rao; SHINDE, Anil Karbhari; KAMBHAMPATI, Ramasastri; ROAYALLEY, Praveen Kumar; JAYARAJAN, Pradeep; BHYRAPUNENI, Gopinadh; PATNALA, Sriramachandra Murthy; RAVULA, Jyothsna; JASTI, Venkateswarlu; WO2013/42135; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

3260-78-4, 6-Chlorobenzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 4: A mixture of 6-chloro-benzofuran-3 (2H)-ONE (1.68 g, 10 mmol) and (carboxymethylene) triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. Afterwards, the reaction mixture was concentrated and loaded over a silica-gel column. The column was eluted with hexane (500 ml) and then with 25% ethyl acetate. The product, ethyl (6-chloro-1-benzofuran-3-yl) acetate, was obtained as a white oil. Yield: 2.1 g (87%) ; (M+H): 239., 3260-78-4

As the paragraph descriping shows that 3260-78-4 is playing an increasingly important role.

Reference£º
Patent; WYETH; WO2004/99191; (2004); A2;,
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Benzofuran | C8H6O – PubChem

115010-11-2, 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 47 Preparation of N-[2R-hydroxy-3-[[(2,3-dihydrobenzofuran-5-yl)sulfonyl](2-methylpropyl)amino]-1S-(phenylmethyl)propyl]-2S-[[(pyrrolidino)acetyl]amino]-3,3-dimethylbutanamide STR92 N-[2R-hydroxy-3-[[(1,1-dimethylethoxy)carbonyl](2-methylpropyl)amino]-1S-(phenylmethyl)propyl]-2S-[[(pyrrolidin-1-yl)acetyl]amino]-3,3-dimethylbutanamide (2 g, 3.57 mmol) in Dioxane/HCl (4N, 10 mL) was stirred for 2 hours at room temperature. The solvent was removed and the residue was dried in vacuo. The residue was stirred in ethyl acetate (50 mL) then 2,3-dihydro benzofuran-5-ylsulfonyl chloride (0.737 g, 3.57 mmol) was added followed by triethylamine (1.587 g, 15.71 mmol) and the mixture was stirred for 18 hours at room temperature. The reaction mixture was diluted with ethyl acetate (100 mL), washed with saturated sodium bicarbonate (saturated, 100 mL) and brine (100 mL), dried (MgSO4), and concentrated. The residue was chromatographed in ethyl acetate to afford the desired product as a white powder.

115010-11-2, The synthetic route of 115010-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; G.D. Searle & Co.; US5756533; (1998); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 27; N-(2,3-dihydro-1-benzofuran-2-ylmethyl)-N’-1H-indazol-4-ylurea; Example 27A; A mixture of 0.5 g (3.05 mmol) of 2,3-dihydro-benzofuran-2-carboxylic acid and 0.83 g (6.09 mmol) of isobutyl chloroformate in 20 mL of tetrahydrofuran and 1.43 mL (10.3 mmol) of triethylamine was stirred for an hour at ambient temperature and filtered. The filtrate was added to 61 mL (30.5 mmol) of 0.5 M ammonia in dioxane and stirred overnight at ambient temperature, filtered and concentrated. The residue was chromatographed on silica gel, eluting with 20 to 80% ethyl acetate in hexane. The residue obtained was again chromatographed on silica gel with 0 to 10% methanol in dichloromethane to provide 0.26 g (52% yield) of Example 27A as a light yellow solid., 1914-60-9

The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Lee, Chih-Hung; Brown, Brian S.; Jinkerson, Tammie K.; Koenig, John R.; Daanen, Jerome F.; Latshaw, Steven P.; US2006/128689; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

90843-31-5, 5-Acetyl-2,3-dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90843-31-5

W-(2,3-Dihydro-1-benzofuran-5-yl)acetamide (192). NH2OH HCI (7.3 g, 105 mmol) was added to a stirred solution of ketone 191 (14.2 g, 87.7 mmol) and pyridine (9.2 mL, 114 mmol) in MeOH (100 mL) and the mixture stirred at 20 0C for 16 h. The solvent was evaporated and the residue partitioned between brine and EtOAc. The organic fraction was dried and the solvent evaporated to give crude 1-(2,3-dihydro-1-benzofuran-5- yl)ethanone oxime (15.3 g, 99%). HCI gas was bubbled through a solution of the oxime (15.3 g, 86.5 mmol) in Ac2O (16.3 mL, 173 mmol) and HOAc (54 mL, 865 mmol), and the solution stood at 20 0C for 24 h. The precipitate was poured into ice/water, stirred for 2 h, the solid filtered and washed with water and dried. The aqueous fraction was extracted EPO with DCM (2 x 50 ml_), the combined organic extract dried and the solvent evaporated. The slurry was treated with water (20 mL) and evaporated several times to remove Ac2O. The combined solids were purified by chromatography, eluting with a gradient (50-100%) of EtOAc/pet. ether, to give acetamide 192 (7.94 g, 52%) as a white solid: mp 92-93 0C [lit. (Blade-Font, A.; de Mas Rocabayera, T. J. Chem. Soc. P1, 1982, 814-848) mp 93 0C]; 1H NMR delta 7.47 (br s, 1 H, H-4), 7.21 (br s, 1 H, NH), 6.99 (dd, J = 8.5, 2.1 Hz, 1 H, H-6), 6.69 (d, J = 8.5 Hz, 1 H, H-7), 4.55 (t, J = 8.7 Hz, 2 H, H-2), 3.18 (br t, J = 8.7 Hz, 2 H, H- 3), 2.13 (S1 3 H1 CH3).

90843-31-5 5-Acetyl-2,3-dihydrobenzo[b]furan 145220, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; AUCKLAND UNISERVICES LIMITED; WO2006/104406; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84594-78-5,6-Nitro-2,3-dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

6,7-Dihydrofuro[3,2-g][1,2,4]benzotrazin-3-amine 1 -Oxide (195). A mixture of nitroaniline 194 (7.27 g, 40.4 mmol) and cyanamide (6.79 g, 162 mmol) were mixed together at 100 C, cooled to 50 0C, cHCI (15 mL) added carefully and the mixture heated at 100 0C for 4 h. The mixture was cooled to 50 C, 7.5 M NaOH solution added until the mixture was strongly basic and the mixture stirred at 100 0C for 3 h. The mixture was cooled, diluted with water (200 mL), filtered, washed with water (3 x 50 mL) and dried. EPO The aqueous fraction was extracted with CHCI3 (3 x 50 mL), dried and the solvent evaporated. The combined solids were purified by chromatography, eluting with a gradient (0-10%) of MeOH/DCM, to give crude amine 195 (1.87 g, 23%) as a yellow powder: mp (MeOH/DCM) 241-246 0C. Anal, calcd for C9H8N4O2: C, 52.9; H, 4.0; N1 27.4. Found: C, 53.3; H, 3.8; N, 26.4%., 84594-78-5

The synthetic route of 84594-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AUCKLAND UNISERVICES LIMITED; WO2006/104406; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84594-78-5,6-Nitro-2,3-dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

84594-78-5, Preparation of 6-nitro-2,3-dihydrobenzofuran Into a 2000 mL 3-necked round-bottom flask, was placed a solution of 6-nitro-2,3-dihydrobenzofuran-5-amine (57 g, 300.83 mmol, 1.00 equiv, 95%) in H20 (1000 mL). To the mixture was added con H2SO4 (570 mL). To the above was added NaNO2 (24 g, 347.83 mmol, 1.10 equiv) in several batches, while cooling to a temperature of 0 C. To the above was added phosphenous acid (114 mL, 50%) dropwise with stirring, while cooling to a temperature of 0 C. The resulting solution was allowed to react, with stirring, for 1 h while the temperature was maintained at 45 C. in a bath of oil. The reaction progress was monitored by TLC (EtOAc/PE=1:2). The resulting solution was extracted two times with 200 mL of EtOAc and the organic layers combined. The resulting mixture was washed 2 times with 150 mL of water. The mixture was dried over Na2SO4 and concentrated by evaporation under vacuum using a rotary evaporator. The residue was purified by eluding through a column with a 1:50 EtOAc/PE solvent system. This resulted in 42 g (76%) of 6-nitro-2,3-dihydrobenzofuran as a red yellow solid.

As the paragraph descriping shows that 84594-78-5 is playing an increasingly important role.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; US2008/200471; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

1914-60-9, 2,3-Dihydrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50).

1914-60-9, 1914-60-9 2,3-Dihydrobenzofuran-2-carboxylic acid 2776555, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.77095-51-3,Benzofuran-6-carboxylic acid,as a common compound, the synthetic route is as follows.,77095-51-3

[00142] The benzofuran carboxylic acid 18? was treated with oxalyl chloride (1.2 equivalents) and a catalytic amount of DMF, stirring for 5.5 hours until a clear solution was obtained. The solvent was removed under reduced pressure and the acid chloride of compound 18? was stored under argon until use, on the next day. The acid chloride, in methylene chloridewas added slowly to a methylene chloride solution of the compound of Formula 12 and diisopropylethylamine (DIPEA) which was cooled to 0-5 C. The reaction was not permitted to rise above 5C, and after completion of addition, was stirred at 5C for a further 0.5 hour. Upon aqueous workup and extraction with methylene chloride, the product, compound 19, was isolated in quantitative yield.

The synthetic route of 77095-51-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SARCODE BIOSCIENCE INC.; ZELLER, James, Robert; VENKATRAMAN, Sripathy; BROT, Elisabeth, C.A.; IYER, Subashree; HALL, Michael; WO2014/18748; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64169-34-2,5-Bromoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

A 500 mL RB flask was charged with aluminum (III) chloride (4.1 g, 31 mmol) and 10 mL of 1, 2-dichloroethane (90 ml, 1142 mmol) , then cooled to 00C. A separate 250 mL flask was charged with 90 mL of 1, 2-dichloroethane (90 ml, 1142 mmol) and cooled to 00C; methylamine (gas) (1.8 g, 59 mmol) was bubbled through the solution for 10 minutes. The dichloroethane solution was slowly poured into the aluminum chloride solution, resulting in the formation of a thick white slush. This was warmed to room temperature. 5-bromoisobenzofuran-1 (3H) -one (5.00 g, 23 mmol) was added in one portion and the reaction mixture was stirred for 2.5 hours and quenched with water. The mixture was filtered to remove the solid impurities, then the filtrate was washed with 0.5N aqueous HCl (100 mL) and brine (200 mL) . The organic layer was dried with MgSO4, filtered, and concentrated to give a white solid. This was triturated with EtOAc and filtered to give 4-bromo-2- (hydroxymethyl) -N-methylbenzamide (3.34 g, 58% yield) as a white solid., 64169-34-2

The synthetic route of 64169-34-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2008/8539; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem