Category: benzofuran

10242-11-2, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.10242-11-2, Name is 5-Bromobenzofuran-2-carboxylic acid, molecular formula is C9H5BrO3, introducing its new discovery.

Synthesis and SAR of highly selective MMP-13 inhibitors

The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.

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Benzofuran – Wikipedia,
Benzofuran | C8H3929O – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Gao, Wendan and a compound is mentioned, 54802-10-7, 3-Aminobenzofuran-2-carboxamide, introducing its new discovery. 54802-10-7

A highly selective diarylethene chemosensor for dual channel recognition of CN? and Zn2+ and its application

A novel diarylethene chemosensor comprising 3-aminobenzofuran-2-carboxamide Schiff base (1O) was synthesized and the photophysical and sensing behaviors of 1O were further investigated. Importantly, the introduction of electron-withdrawing group to 1O made the sensor an efficient tool for detection of toxic cyanide even in the presence of other plausible interfering anions including fluoride and acetate. In particular, addition of CN? to 1O visibly changes the color from colorless to orange-red, which can be observed by the naked eye. Apart from this, it also exhibited an outstanding fluorometric sensing toward Zn2+ with high selectivity and sensitivity. Moreover, the remarkable spectral responses of the devised sensor prompted us to fabricate molecular logic circuit. Furthermore, the sensor was successfully applied to the detection of CN? on test strips and silica coated microslides, and the methods were very simple to operate without resorting to any spectroscopic instrumentation. In addition, the 1O can also effectively detect CN? and Zn2+ in actual water samples.

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Benzofuran – Wikipedia,
Benzofuran | C8H2820O – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 3199-61-9, Name is Ethyl benzofuran-2-carboxylate,introducing its new discovery., 3199-61-9

Synthesis of Perfluoroalkyl-Substituted Vinylcyclopropanes by Way of Enhanced Neighboring Group Participation

A simple, high yielding, two-step, one-pot protocol for the preparation of trifluoromethyl-substituted vinylcyclopropanes from alpha-CF3 homoallyl alcohols is disclosed. Destabilization of the cationic intermediate by the electron-withdrawing CF3 group greatly enhances neighboring group participation of the alkene, allowing ring closure to predominate. The reaction can be extended to the difluoromethyl and pentafluoroethyl group, enabling the preparation of a diverse array of fluoroalkyl-substituted vinylcyclopropanes. A diverse array of fluoroalkyl-substituted vinylcyclopropanes are prepared in a simple, high-yielding, two-step, one-pot protocol by means of cationic ring-closure.

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Benzofuran – Wikipedia,
Benzofuran | C8H3029O – PubChem

10242-11-2, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 10242-11-2, molcular formula is C9H5BrO3, introducing its new discovery.

NOVEL INDENE DERIVATIVE, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITION, FOR PREVENTING OR TREATING RETINAL DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel indene derivative, a preparation method for the same, and a pharmaceutical composition for preventing or treating retinal disease comprising the same as an active ingredient. The novel indene derivative of the present invention, the optical isomer of the same, or the pharmaceutically acceptable salts of the same have excellent inhibitory efficiency of receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Therefore, the composition containing the same as an active ingredient can be effectively used as a pharmaceutical composition for preventing or treating retinal disease exemplified by retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardts disease, Usher syndrome, choroideremia, rod-cone or cone-rod dystrophy, ciliopathy, mitochondrial disorders, progressive retinal atrophy, degenerative retinal diseases, age-related macular degeneration (AMD), wet AMD, dry AMD, geographical atrophy, inherited or acquired macular degeneration, retinal photoreceptor diseases, retinal pigment epithelial diseases, diabetic retinopathy, cystic macular edema, uveitis, retinal detachment, traumatic retinal injury, iatrogenic retinal injury, macular holes, macular capillarectasia, ganglion cell diseases, optic nerve diseases, glaucoma, optic neuropathy, ischemic retinal diseases, retinopathy of prematurity, occlusion of retinal vessels, inherited macroaneurysm, retinal vascular diseases, ophthalmic vascular diseases, glaucomatous retinal neurodegeneration, ischemic optic neuropathy and the like.

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Benzofuran – Wikipedia,
Benzofuran | C8H3906O – PubChem

4265-25-2, In an article, published in an article,authors is Carril, Monica, once mentioned the application of 4265-25-2, Name is 2-Methylbenzofuran,molecular formula is C9H8O, is a conventional compound. this article was the specific content is as follows.

On-water chemistry: Copper-catalyzed straightforward synthesis of benzo[b]furan derivatives in neat water

A more sustainable protocol leading to 2-alkyl- or 2-aryl-substituted benzo[b]furans is reported, involving a copper-TMEDA complex which catalyzes the transformation of readily available ketone derivatives into the corresponding benzofurans in good to excellent yields. The reaction is accomplished using water as the solvent without organic cosolvents, and one example of catalyst reutilization is also presented.

4265-25-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4265-25-2

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Benzofuran – Wikipedia,
Benzofuran | C8H72O – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. 4265-25-2. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.4265-25-2, Name is 2-Methylbenzofuran, molecular formula is C9H8O, introducing its new discovery.

Bio-based nickel alginate and copper alginate films with excellent flame retardancy: Preparation, flammability and thermal degradation behavior

A bio-based nickel alginate film and copper alginate film were prepared via a facile ion exchange and casting approach. Their flame retardancy, thermal degradation and pyrolysis behavior, and thermal degradation mechanism were investigated systematically by the limiting oxygen index (LOI), vertical burning (UL-94), microscale combustion calorimetry (MCC), thermogravimetric analysis (TGA), thermogravimetric analyzer coupled with Fourier transform infrared analysis (TG-FTIR) and pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS). It was shown that the nickel alginate film had a much higher LOI value (50.0%) than those of the sodium alginate film (24.5%) and copper alginate film (23.0%). Moreover, the nickel alginate film passed the UL-94 V-0 rating, while the sodium alginate film and copper alginate film showed no classification. Importantly, the peak of heat release rate (PHRR) of the nickel alginate film in the MCC test was much lower than those of the copper alginate film and sodium alginate film. This indicated that the introduction of nickel ions decreased the release of combustible gases. TGA results showed that the addition of copper ions and nickel ions accelerated the thermal degradation of alginates and changed the thermal degradation mechanism of the alginates. TG-FTIR and Py-GC-MS results indicated that the pyrolysis of copper alginate and nickel alginate produced much less flammable products than that of sodium alginate in the whole thermal degradation process. Finally, a possible degradation mechanism for copper alginate and nickel alginate was proposed. The results of our study provide useful information for understanding the flame retardancy mechanism of alginate as well as for designing bio-based materials with excellent fire retardancy.

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Benzofuran – Wikipedia,
Benzofuran | C8H185O – PubChem

10242-08-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 10242-08-7, molcular formula is C10H8O4, introducing its new discovery.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

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Benzofuran – Wikipedia,
Benzofuran | C8H3084O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 90843-31-5, In a patent£¬Which mentioned a new discovery about 90843-31-5

Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents

This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein A is C 1-6 alkylene or ?NR1?; Z is C(=L)R2, or SO2R3; U is CH or N; W and Y are independently selected from ?CH2?, O, S and ?N?R1; m is 1, 2 or 3; q and r are independently 0, 1 or 2; X is independently selected from halogen, C1-4 alkyl, halo-substituted C1-4 alkyl, hydroxy, C1-4 alkoxy, halo-substituted C1-4 alkoxy or the like; n is 1 or 2; L is oxygen or sulfur; R1 is hydrogen or C1-4 alkyl; R2 is hydroxy, C1-6alkyl, halo-substituted C1-6 alkyl, C1-6 alkoxy, halo-substituted C1-6 alkoxy, C3-7 cycloalkoxy, C1-4 alkyl(C3-7 cycloalkoxy), ?NR4R5 or the like; R3 is C1-6 alkyl or halo-substituted C1-6 alkyl; and R4 and R5 are independently selected from hydrogen, C1-6 alkyl and halo-substituted C1-6alkyl.This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

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Benzofuran – Wikipedia,
Benzofuran | C8H2058O – PubChem

4265-25-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4265-25-2, Name is 2-Methylbenzofuran, molecular formula is C9H8O. In a article£¬once mentioned of 4265-25-2

Direct conversion of glycerol into bio-oil via hydrotreatment using supported metal catalysts

Hydrotreatment of glycerol (a byproduct of bio-diesel production) was conducted in the presence of a number of different supported metal catalysts at a temperature of 300 C under 5 MPa initial pressure of H2. The bio-oil products were comprehensively characterized to determine their physical/chemical properties. Experiments with supported catalyst metals revealed a positive correlation between support acidity and bio-oil yield. It was determined that MoCoP is the most effective combination of catalyst metals, and the bio-oil yield from hydro-treatment of glycerol with the MoCoP catalysts is strongly dependent on the support materials, following the trend of MgO < AC < Al2O3 < zeolite. With the MoCoP/zeolite catalyst, a maximum yield of ?40 wt.% bio-oil, and >90% glycerol conversion was achieved for 60 min reaction. The volatile components of the bio-oil were found to consist mostly of substituted phenols and ketones in the C6-C9 range. The bio-oils obtained had a maximum HHV of 33 MJ/kg and the majority (?95%) of the compounds present was found to have boiling points lower than 165 C, making these bio-oils potential oxygenated fuel additives.

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Benzofuran – Wikipedia,
Benzofuran | C8H298O – PubChem

In an article, published in an article,authors is Bonse, Gerhard, once mentioned the application of 66826-78-6, Name is 5-Bromo-2,3-dihydrobenzofuran,molecular formula is C8H7BrO, is a conventional compound. this article was the specific content is as follows. 66826-78-6

Acylation of Amines with Dichloromaleoyl Chloride

The reaction of dichloromaleoyl chloride (2) with ammonia in ether yields the ammonium salt of (Z)-2,3-dichloro-3-cyanoacrylic acid (6) and with aqueous ammonia the ammonium salt of (Z)-2-amino-3-chloro-3-cyanoacrylic acid (1).With primary aliphatic and aromatic amines dichloromaleamides 8 are obtained, the two chlorine atoms of which can be replaced with other amines to form after cis/trans isomerization diaminofumaramides 11.

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Benzofuran – Wikipedia,
Benzofuran | C8H3356O – PubChem