Category: 767291-67-8

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Canipa, Steven J.; Stute, Annika; O’Brien, Peter researched the compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine( cas:767291-67-8 ).Synthetic Route of C20H42N2.They published the article 《Use of copper(II)/diamine catalysts in the desymmetrization of meso-diols and asymmetric Henry reactions: comparison of (-)-sparteine and (+)-sparteine surrogates》 about this compound( cas:767291-67-8 ) in Tetrahedron. Keywords: acylation benzoylation Henry reaction catalyst copper diamine sparteine. We’ll tell you more about this compound (cas:767291-67-8).

Four new copper(II)/diamine complexes comprising some (+)-sparteine surrogates and a cyclohexane-derived diamine were prepared and evaluated as chiral catalysts in desymmetrization of meso-diols and an asym. Henry reaction. A mono-benzoylation reaction generated two products with high enantioselectivity (90:10 to 97:3 er). An asym. Henry reaction gave nitro alcs. in 90:10 to 98:2 enantiomeric ratio (er). Notably, the sense of induction with the (+)-sparteine surrogates was opposite to that obtained using the copper(II)/(-)-sparteine complex. One of the nitro alc. products was used in a concise synthesis of a chiral morpholine derivative, (2S)-2-phenylmorpholine. Under optimized conditions the synthesis of the target compounds was achieved using (1R,2S)-rel-1,2-diphenyl-1,2-ethanediol and benzoyl chloride as starting materials and (7S,7aR,14S,14aS)-dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine-copper complex [(-)-sparteine-copper complex] as catalyst. The title compound thus formed was (1S,2R)-1,2-diphenyl-1,2-ethanediol 1-benzoate. Using a sparteine surrogate, such as (+)-(1R,5S,11aS)-Decahydro-3-methyl-1,5-methano-2H-pyrido[1,2-a][1,5]diazocine-copper complex gave (1R,2S)-1,2-diphenyl-1,2-ethanediol 1-benzoate.

Different reactions of this compound((1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine)Synthetic Route of C20H42N2 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 767291-67-8, is researched, Molecular C20H42N2, about The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand, the main research direction is sparteine chiral catalyst stereoselective alkylation hydrazone.Synthetic Route of C20H42N2.

An asym. alkylation of ketones represents a fundamental transformation in organic chem. Chiral auxiliaries have been used almost exclusively for this transformation. Herein the authors describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83:17, using a chiral ligand protocol. The synthesis of the target compounds was achieved using 3-pentanone 2,2-dimethylhydrazone, 4-heptanone 2,2-dimethylhydrazone, Cycloheptanone 2,2-dimethylhydrazone, benzyl bromide,1-iodopentane, 1-iodohexane, allyl, bromide as starting materials. (7R,7AR,14R,14aS)-dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine [alkaloid, (+)-sparteine] and (7S,7aR,14S,14aS)-dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1′,2′-e][1,5]diazocine [(-)-sparteine] were used as chiral ligands. The title compounds thus formed included (2R)-2-methyl-1-phenyl-3-pentanone, (4S)-4-methyl-3-nonanone, (2R)-2-(2-propen-1-yl)cycloheptanone, (2S)-2-(2-propen-1-yl)cycloheptanone.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Stereoselective Synthesis of 5-Substituted Pyrrolo[1,2-c]imidazol-3-ones: Access to Annulated Chiral Imidazol(in)ium Salts, published in 2010-01-01, which mentions a compound: 767291-67-8, mainly applied to pyrroloimidazolone stereoselective lithiation phosphorus oxychloride salt formation; heterocyclic carbene precursor stereoselective preparation palladium complexation; palladium heterocyclic carbene complex preparation, Name: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine.

A two-step synthesis of N-heterocyclic carbene (NHC) precatalysts by diastereoselective or enantioselective lithiation of pyrrolo[1,2-c]imidazol-3-ones followed by POCl3-induced salt formation is described. The resulting 3-chloro-pyrroloimidazol(in)ium salts may be coordinated to palladium(II) upon NHC generation with t-BuLi at low temperature The method may facilitate exploitation of these compounds as chiral organocatalysts or ligands in metal catalysis.

Although many compounds look similar to this compound(767291-67-8)Name: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine, numerous studies have shown that this compound(SMILES:CN(CCC(C)(C)C)[C@@H]1[C@@H](N(CCC(C)(C)C)C)CCCC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 767291-67-8, is researched, Molecular C20H42N2, about Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines, the main research direction is enantioselective addition methyllithium aromatic imine diamine ligand.Computed Properties of C20H42N2.

A new tertiary pseudo C2-sym. diamine derived from (1S,2S)-(+)-pseudoephedrine was synthesized and tested in the enantioselective addition of methyllithium on different aromatic imines. A comparative study with a similar C2-sym. ligand derived from the cyclohexane diamine showed better reactivity and enantioselectivity up to 91%.

Compounds in my other articles are similar to this one((1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine)Computed Properties of C20H42N2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine, is researched, Molecular C20H42N2, CAS is 767291-67-8, about Effect of Ligand Structure on the Asymmetric Cyclization of Achiral Olefinic Organolithiums. Author is Mealy, Michael J.; Luderer, Matthew R.; Bailey, William F.; Sommer, Michael Bech.

The ability of a large and chem. diverse set of 30 chiral ligands to effect asym. cyclization of 2-(N,N-diallylamino)phenyllithium (I), derived from N,N-diallyl-2-bromoaniline by low-temperature lithium-bromine exchange, has been investigated in an attempt to elucidate the structural motifs required to provide high enantiofacial selectivity in the ring closure. Although none of the ligands examined in this study afforded 1-allyl-3-methylindoline in significantly higher ee than previously observed for the cyclization of I in the presence of the benchmark ligand (-)-sparteine, several ligands, structurally unrelated to sparteine and available in either enantiomeric form, were found to match the utility of (-)-sparteine in this chem.

In some applications, this compound(767291-67-8)Recommanded Product: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine( cas:767291-67-8 ) is researched.Synthetic Route of C20H42N2.Barker, Graeme; McGrath, Julia L.; Klapars, Artis; Stead, Darren; Zhou, George; Campos, Kevin R.; O’Brien, Peter published the article 《Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc Pyrrolidine: In Situ React IR Spectroscopic Monitoring, Scope, and Synthetic Applications》 about this compound( cas:767291-67-8 ) in Journal of Organic Chemistry. Keywords: palladium catalyst enantioselective arylation BOC pyrrolidine IR spectroscopy. Let’s learn more about this compound (cas:767291-67-8).

A comprehensive study of the enantioselective Pd-catalyzed α-arylation of N-Boc pyrrolidine, e.g. I, has been carried out. The protocol involves deprotonation of N-Boc pyrrolidine using s-BuLi/(-)-sparteine in TBME or Et2O at -78 °C, transmetalation with ZnCl2 and Negishi coupling using Pd(OAc)2, t-Bu3P-HBF4 and the aryl bromide. This paper reports several new features including in situ React IR spectroscopic monitoring of the process; use of (-)-sparteine and the (+)-sparteine surrogate to access products with opposite configuration; development of a catalytic asym. lithiation-Negishi coupling reaction; extension to a wide range of heteroaromatic bromides; total synthesis of (R)-crispine A, (S)-nicotine and (S)-SIB-1508Y via short synthetic routes; and examples of α-vinylation of N-Boc pyrrolidine using vinyl bromides exemplified by the total synthesis of naturally occurring (+)-maackiamine (thus establishing its configuration as (R)). In this way, the full scope and limitations of the methodol. are delineated.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Chemical Communications (Cambridge, United Kingdom) called Mechanistic interrogation of the asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine, Author is Rayner, Peter J.; Smith, Joshua C.; Denneval, Charline; O’Brien, Peter; Clarke, Paul A.; Horan, Richard A. J., which mentions a compound: 767291-67-8, SMILESS is CN(CCC(C)(C)C)[C@@H]1[C@@H](N(CCC(C)(C)C)C)CCCC1, Molecular C20H42N2, Application In Synthesis of (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine.

A fundamental mechanistic study of the s-BuLi/chiral diamine-mediated lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine is reported. We show that lithiated thiopivalamides are configurationally unstable at -78 °C. Reaction then proceeds via a dynamic resolution of diastereomeric lithiated intermediates and this accounts for the variable sense and degree of asym. induction observed compared to N-Boc heterocycles.

Here is just a brief introduction to this compound(767291-67-8)Application In Synthesis of (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine, more information about the compound((1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine) is in the article, you can click the link below.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Safety of (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine, is researched, Molecular C20H42N2, CAS is 767291-67-8, about Asymmetric Lithiation Trapping of N-Boc Heterocycles at Temperatures above -78 °C. Author is Gelardi, Giacomo; Barker, Graeme; O’Brien, Peter; Blakemore, David C..

The asym. lithiation trapping of N-Boc heterocycles using s-BuLi/chiral diamines at temperatures up to -20 °C is reported. Depending on the N-Boc heterocycle, lithiation is accomplished using s-BuLi and (-)-sparteine or the (+)-sparteine surrogate in the temperature range -50 to -20 °C for short reaction times (2-20 min). Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered functionalized N-Boc heterocycles in 47-95% yield and 77:23-93:7 er. With N-Boc pyrrolidine, trapped products can be generated in ∼90:10 er even at -20 °C [e.g., 2 min reaction time at -20 °C afforded I (50% yield, 89:11 er) and II (23% yield, 91:9 er)].

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Preparation and Reactions of Enantiomerically Pure α-Functionalized Grignard Reagents, Author is Rayner, Peter J.; O’Brien, Peter; Horan, Richard A. J., which mentions a compound: 767291-67-8, SMILESS is CN(CCC(C)(C)C)[C@@H]1[C@@H](N(CCC(C)(C)C)C)CCCC1, Molecular C20H42N2, Recommanded Product: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine.

A strategy for the generation of enantiomerically pure α-functionalized chiral Grignard reagents is presented. The approach involves the synthesis of α-alkoxy and α-amino sulfoxides in ≥99:1 dr and ≥99:1 er via asym. deprotonation (s-BuLi/chiral diamine) and trapping with Andersen’s sulfinate (menthol derived). Subsequent sulfoxide → Mg exchange (room temperature, 1 min) and electrophilic trapping delivers a range of enantiomerically pure α-alkoxy and α-amino substituted products. Using this approach, either enantiomer of products can be accessed in 99:1 er from asym. deprotonation protocols without the use of (-)-sparteine as the chiral ligand. Two addnl. discoveries are noteworthy: (i) for the deprotonation and trapping with Andersen’s sulfinate, there is a lack of stereospecificity at sulfur due to attack of a lithiated intermediate onto the α-alkoxy and α-amino sulfoxides as they form, and (ii) the α-alkoxy-substituted Grignard reagent is configurationally stable at room temperature for 30 min.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine( cas:767291-67-8 ) is researched.COA of Formula: C20H42N2.Gu, Xiaoyu; Tang, Yan; Zhang, Xiang; Luo, Zinbin; Lu, Hongfei published the article 《Organocatalytic Knoevenagel condensation by chiral C2-symmetric tertiary diamines》 about this compound( cas:767291-67-8 ) in New Journal of Chemistry. Keywords: aldehyde malonate chiral diaminocyclohexane enantioselective Knoevenagel condensation organocatalyst; unsaturated diester stereoselective preparation dynamic kinetic resolution. Let’s learn more about this compound (cas:767291-67-8).

The efficient Knoevenagel condensation catalyzed by (1S,2S)-1,2-diaminocyclohexane derivatives is presented and investigated. Various aliphatic aldehydes undergo condensation with active methylene compounds to yield the corresponding products in high yields. α-Branched aldehydes were found to be efficiently converted to the corresponding enantiomerically enriched products by using these chiral tertiary diamine catalysts.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem