Category: 76429-69-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76429-69-1,5-Chloro-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

76429-69-1, Intermediate 10: 5-chloro-7-nitro-2,3-dihydro-1 -benzofuran; To a mixture of 5-chloro-2,3-dihydro-1-benzofuran (prepared by the method of :Ramon J. Alabaster*, Ian F. Cottrell, Hugh Marley, Stanley H. B. Wright Synthesis (1988), (12), 950-952) (4.3g) in glacial acetic acid (20ml) and concentrated sulphuric acid (4ml) at 1000C was added concentrated nitric acid (1.57ml) and glacial acetic acid (1 ml). After forty five minutes, the mixture was allowed to cool and dissolved in dichloromethane (250ml). The organic layer was washed with water (250ml), 1 M ammonium hydroxide (250ml) and water (250ml) and then dried (MgSO4) and evaporated. The solid was dissolved in dichloromethane and applied to a column and the column eluted to afford the title compound as a yellow solid (3.4g).

As the paragraph descriping shows that 76429-69-1 is playing an increasingly important role.

Reference£º
Patent; Glaxo Group Limited; WO2007/88168; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

76429-69-1, 5-Chloro-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76429-69-1, a) To a stirred and cooled mixture of 32 nil of sulfuric acid and 14 ml of water there were added 17 g of 2,3-dihydro-5-chlorobenzofuran, while keeping the temperature at 25 C. After cooling to 0 C., there were added dropwise 14 ml of nitric acid. Stirring and cooling at 0 C. was continued for 44 hours. The reaction mixture was diluted with water (temp. <10 C.) and stirred for 15 min. The precipitate was filtered off, washed with water and recrystallized from a mixture of ethyl acetate and hexane (30:70), yielding 8.9 g (40.5%) of 5-chloro-2,3-dihydro-7-nitrobenzofuran (interm. 3). 76429-69-1 5-Chloro-2,3-dihydrobenzofuran 592964, abenzofuran compound, is more and more widely used in various. Reference£º
Patent; Janssen Pharmaceutica N.V.; US5407961; (1995); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem