Category: 64169-67-1

New explortion of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 64169-67-1, name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, introducing its new discovery. Safety of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

The present invention is directed to novel processes for the preparation of citalopram comprising halogenation of a phthalide compound of formula II, wherein R is a suitable group to be changed to CN, to afford an acid halogenide compound of formula III wherein R is as defined above and X is halogen, and thereafter obtaining citalopram through two successive reactions with suitable organometallic halides or organoboranes or by a reaction with organometallic 4-fluorophenylhalide or 4-fluorophenylborane followed by reduction and alkylation, and an exchange of R to cyano to afford citalopram. The order of the reactions can be varied depending e.g. on the starting compound used.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3883O – PubChem

Awesome Chemistry Experiments For 64169-67-1

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 64169-67-1

Reference of 64169-67-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, molecular formula is C15H10FNO. In a Article，once mentioned of 64169-67-1

The development of efficient and selective nanostructured catalysts for industrially relevant hydrogenation reactions continues to be an actual goal of chemical research. In particular, the hydrogenation of nitriles and nitroarenes is of importance for the production of primary amines, which constitute essential feedstocks and key intermediates for advanced chemicals, life science molecules and materials. Herein, we report the preparation of graphene shell encapsulated Co3O4- and Co-nanoparticles supported on carbon by the template synthesis of cobalt-terephthalic acid MOF on carbon and subsequent pyrolysis. The resulting nanoparticles create stable and reusable catalysts for selective hydrogenation of functionalized and structurally diverse aromatic, heterocyclic and aliphatic nitriles, and as well as nitro compounds to primary amines (>65 examples). The synthetic and practical utility of this novel non-noble metal-based hydrogenation protocol is demonstrated by upscaling several reactions to multigram-scale and recycling of the catalyst.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3898O – PubChem

Archives for Chemistry Experiments of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 64169-67-1. In my other articles, you can also check out more blogs about 64169-67-1

Synthetic Route of 64169-67-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, molecular formula is C15H10FNO. In a Article，once mentioned of 64169-67-1

A ligand-free iron-catalyzed method for the oxygenation of benzylic sp3 C-H bonds by molecular oxygen (1 atm) using a thiyl radical as a cocatalyst has been developed. This transformation provides a facile access to amides, esters and ketones from readily accessible corresponding amines, ethers and alkanes. It features high regioselectivity, mild oxidative conditions and excellent functional group compatibility, providing good opportunities to the site-selective functionalization of complex molecules. Preliminary mechanistic studies suggest that this reaction may not undergo a benzylic cation intermediate pathway and the carbonyl oxygen atom in the products may be derived from molecular oxygen.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3896O – PubChem

Final Thoughts on Chemistry for 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 64169-67-1, and how the biochemistry of the body works.Synthetic Route of 64169-67-1

Synthetic Route of 64169-67-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, molecular formula is C15H10FNO. In a Patent£¬once mentioned of 64169-67-1

IMPROVED PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-1-(4-?FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURANS

The present invention provides a process for the preparation of a 5-substituted-l-(4-fluorophenyl)-1,3-dihydro-isobenzofuran of Formula (2), an intermediate for the manufacture of citalopram, which process comprises: (a) carrying out a Grignard reaction on a corresponding 5-substituted phthalide of Formula (3) in a co-solvent system, comprising adding (i) prepared 4-fluorophenyl magnesium halide in an ether solvent to (ii) the 5-substituted phthalide in a suitable organic co-solvent to the ether solvent, to form a corresponding 4-substituted-2-hydroxymethyl-4′-fluorobenzophenone of Formula (4); (b) carrying out a ketone reduction of the 4-substituted-2-hydroxymethyl-4′-fluorobenzophenone of Formula (4) following the Grignard reaction, to form a corresponding 4-substituted-2-hydroxymethylphenyl- 1-(4-fluorophenyl) methanol of Formula (5); and (c) carrying out a cyclisation reaction on the 4-substituted-2 hydroxymethylphenyl- 1-(4-fluorophenyl) methanol of Formula (5) following the reduction reaction, to form said intermediate of Formula (2); wherein R represents Br or CN.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3886O – PubChem

Top Picks: new discover of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 64169-67-1, and how the biochemistry of the body works.COA of Formula: C15H10FNO

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 64169-67-1, name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, introducing its new discovery. COA of Formula: C15H10FNO

PRODUCTION METHOD OF CITALOPRAM, INTERMMEDIATE THEREFOR AND PRODUCTION METHOD OF THE INTERMEDIATE

Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula [VI] with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,N?,N?-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula [III], which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula [II] to reduction and cyclization. 1

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 64169-67-1, and how the biochemistry of the body works.COA of Formula: C15H10FNO

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3892O – PubChem

Discovery of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, molecular formula is C15H10FNO

PROCESS FOR THE PREPARATION OF HIGH PURITY CITALOPRAM AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

This invention discloses an improved process for the preparation of high purity citalopram base and its hydrobromide salt of formulae (I) and (Ia): which comprises: i. Isolation of crude citalopram base after water work up of the reaction into a non polar aromatic or dialkyl ether solvent. ii. Extraction of the citalopram base into aqueous organic acid. iii. Neutralization of acid layer with organic base to a controlled pH (7.0-8.0) iv. Extraction of the pure base into a non-polar aromatic or dialkyl ether solvent and crytallization form the same solvent after concentrating to certain volume under reduced pressure. v. Preparation of high purity citalopram hydrobromide in a non-polar aromatic or dialkyl ether solvent using 40-50 % HBr in acetic acid as HBr source and crystallizing out form the same solvent. Alternatively preparation of HBr salt in aqueous medium using aqueous HBr and crystallizing out from the same medium at 0 10 C. vi. Recrystallization of high purity citalopram hydrobromide salt of pharmaceutically acceptable grade form a mixture of alcoholic solvent.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3884O – PubChem

Top Picks: new discover of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 64169-67-1, and how the biochemistry of the body works.Synthetic Route of 64169-67-1

Synthetic Route of 64169-67-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile,introducing its new discovery.

ONE POT SYNTHESIS OF CITALOPRAM FROM 5-CYANOPHTHALIDE

A process for one pot synthesis of citalopram is disclosed. The process comprises subjecting 5-cyano phthalide to Grignard reduction followed cyclization and followed by C-alkylation reaction to obtain citalopram without isolation and purification of any intermediates. In another embodiment, 5-cyano phthalide is subjected to sequential Grignard reactions followed by cyclization to obtain citalopram without isolation and purification of any intermediate stages.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3885O – PubChem

New explortion of 64169-67-1

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, HPLC of Formula: C15H10FNO, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 64169-67-1

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C15H10FNO, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, molecular formula is C15H10FNO

alpha-Fluorination of carbonyls with nucleophilic fluorine

Given the unique properties of fluorine, and the ability of fluorination to change the properties of organic molecules, there is significant interest from medicinal chemists in innovative methodologies that enable the synthesis of new fluorinated motifs. State-of-the-art syntheses of alpha-fluorinated carbonyl compounds invariably rely on electrophilic fluorinating agents, which can be strongly oxidizing and difficult to handle. Here we show that reversing the polarity of the enolate partner to that of an enolonium enables nucleophilic fluorinating agents to be used for direct chemoselective alpha-C?H-fluorination of amides. Reduction of these products enables facile access to beta-fluorinated amines and the value of this methodology is shown by the easy preparation of a number of fluorinated analogues of drugs and agrochemicals. A fluorinated analogue of citalopram, a marketed antidepressant drug, is presented as an example of the preserved biological activity after fluorination.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3893O – PubChem

Properties and Exciting Facts About 64169-67-1

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Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C15H10FNO, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 64169-67-1

PROCESS FOR PREPARING 5-SUBSTITUTED -1-(4-FLUOROPHENYL) -1,3-DIHYDROISOBENZOFURANS

The present invention relates to a method for preparation and isolation of hitherto unknown solid boron complex of formula (v), which are obtained when 5-substituted phthalides are reacted with a solution of 4-fluorophenylmagnesiumbromide, followed by in situ reduction and complex formation in the presence of sodiumborohydride. Such boron complexes can be conveniently filtered to remove structurally similar impurities and subsequently subjected to cyclisation reaction in acidic medium to get high pure 5-substituted phthalens, which are key starting materials for manufacturing citalopram and pharmaceutically acceptable acid addition salts.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3887O – PubChem