In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 64169-67-1, name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, introducing its new discovery. Safety of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
The present invention is directed to novel processes for the preparation of citalopram comprising halogenation of a phthalide compound of formula II, wherein R is a suitable group to be changed to CN, to afford an acid halogenide compound of formula III wherein R is as defined above and X is halogen, and thereafter obtaining citalopram through two successive reactions with suitable organometallic halides or organoboranes or by a reaction with organometallic 4-fluorophenylhalide or 4-fluorophenylborane followed by reduction and alkylation, and an exchange of R to cyano to afford citalopram. The order of the reactions can be varied depending e.g. on the starting compound used.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 64169-67-1, and how the biochemistry of the body works.Safety of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3883O – PubChem