Discovery of 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 64169-67-1

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 64169-67-1, Name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, molecular formula is C15H10FNO

PROCESS FOR THE PREPARATION OF HIGH PURITY CITALOPRAM AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

This invention discloses an improved process for the preparation of high purity citalopram base and its hydrobromide salt of formulae (I) and (Ia): which comprises: i. Isolation of crude citalopram base after water work up of the reaction into a non polar aromatic or dialkyl ether solvent. ii. Extraction of the citalopram base into aqueous organic acid. iii. Neutralization of acid layer with organic base to a controlled pH (7.0-8.0) iv. Extraction of the pure base into a non-polar aromatic or dialkyl ether solvent and crytallization form the same solvent after concentrating to certain volume under reduced pressure. v. Preparation of high purity citalopram hydrobromide in a non-polar aromatic or dialkyl ether solvent using 40-50 % HBr in acetic acid as HBr source and crystallizing out form the same solvent. Alternatively preparation of HBr salt in aqueous medium using aqueous HBr and crystallizing out from the same medium at 0 10 C. vi. Recrystallization of high purity citalopram hydrobromide salt of pharmaceutically acceptable grade form a mixture of alcoholic solvent.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3884O – PubChem