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Titanium(III) chloride reacts with schiff bases derived from benzaldehydes/acetophenone with 3-amino-2-benzofuran carboxamide/ethyl-3-amino- 2-benzofuran carboxylate to yield complexes having general composition[Ti.2L. 2H2O]Cl3 (where L=schiff base). The ligands and their corresponding Ti(III) complexes have been characterised by elemental analyses, molar conductance,magnetic susceptibility, IR & electronic spectra and TGA. The ligands act in a bidentate manner. Based on these studies octahedral geometries have been proposed for these complexes. The ligands and their Ti(III)complexes have screened for antibacterial activities.

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Reaction of 3-aminobenzofuran-2-carboxamide (1) with aryl isothiocyanates under different conditions results into 3-aryl-2,3-dihydro-2-thioxoxbenzofuro<3,2-d>pyrimidin-4(1H)-ones (3), through the intermediate 1-(2-carbamoyl-3-benzofuranyl)-2-thio-3-arylurea(4)

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We report a new sensor, 1, for sequentially detecting Zn2+ and CN- based on fluorescence. Sensor 1 was prepared through the reaction of 3-aminobenzofuran-2-carboxamide with 4-diethylaminosalicylaldehyde. Sensor 1 showed a selective “off-on” fluorescent response toward Zn2+, distinguishing Zn2+ from Cd2+. The limit of 1 (0.35 muM) for monitoring Zn2+ is lower than the World Health Organization (WHO) guideline (76 muM) for water available for drinking. Importantly, sensor 1 could sense Zn2+ in living cells and aqueous media. In addition, the resulting 1-Zn2+ complex functioned as an efficient “on-off” sensor for CN-. The mechanisms of 1 for detecting Zn2+ and CN- were explained by spectroscopic, spectrometric, and theoretical studies.

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C from CO! A straightforward procedure for the carbonylative synthesis of quinazolinones from readily available 2-aminobenzamide and aryl bromides has been developed. In the presence of a palladium catalyst, various quinazolinones were produced in moderate to excellent yields. Remarkably, no chromatography was needed for purification (see scheme). Copyright

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This invention relates to macrocyclic compounds shown in the specification. These compounds can be used to treat hepatitis C virus infection

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Acylation of 3-aminobenzofuran-2-carboxamide using succinic, maleic and phthalic anhydrides under different conditions followed by cyclodehydration of the resultant products (Ia-c) gives 2-substituted-3,4-dihydro-4-oxobenzofuro<3,2-d>pyrimidines (IIa-c) which on further cyclodehydration furnish new polycyclic heterocycles, 2,3-dihydrobenzofuro<3,2-d>pyrrolo<1,5-a>pyrimidine-1,10-dione (IV), benzofuro<3,2-d>pyrrolo<1,5-a>pyrimidine-1,10-dione (V) and benzofuro<3,2-d>isoindolo(1,7-a>pyrimidine-11,12-dione (VI), respectively.Reaction of psi-saccharin chloride with 3-aminobenzofuran-2-carboxylic acid derivatives leads to the formation of 2-(o-sulphamoylphenyl)-3,4-dihydro-4-oxobenzofuro<3,2-d>pyrimidine (VIII) and a new pentacyclic heterocycle 7-oxobenzofuro<3',2':4,5>pyrimido<1,2-b>benzothiazole-5,5-dioxide (IX).

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The displacement reaction of 2-(4-N,N-dimethyl/nitrophenyl)-4-oxo-benzofuro [3,2-d] pyrimidine 1-2 with phosphorus oxychloride yielded 2-(4-N,N-dimethyl/ nitrophenyl)-4- chlorobenzofuro [3,2-d] pyrimidines 3-4. 2-[4-N,N-Dimethyl/ nitrophenyl]-4- hydrazinobenzofuro [3,2-d] pyrimidines 5-6 were prepared by the reaction of 3-4 with hydrazine hydrate. Compounds 5-6 upon treatment with sodium azlde and triethylorthoformate gave 5-(4-N,N-dimethyl/nitrophenyl)-triazoio [4,3-c] pyrimido [5,4- b] benzofurans 7-8 and 5-(4-N,N-dimethyl/nitrophenyl)- triazolo [1,5-c] pyrimido [5,4-b] benzofurans. 9-10.4-Hydrazino compounds 5-6 were also subjected to condensation with aromatic aldehydes which afforded 2-(4-N,N-dimethyl/nitrophenyl)-4-arylidene hydrazinobenzofuro [3,2-d] pyrimidines 11-20. All synthesized compounds were characterized on the basis of spectral studies and further these compounds were evaluated for antimicrobial and antitubercular activities.

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2-(4-Nitrophenyl)-3,4-dihydro-4-oxobenzofuro [3,2-d] pyrimidine 2 was prepared by the reaction of 3-amino-2-benzofurancarboxamide 1 with 4-nitrobenzaldehyde in presence of catalytic quantity of cone hydrochloric acid. The nucleophilic displacement reaction of compound 2 with phosphorus oxychloride furnished 2-(4-nitrophenyl-3,4-dihydro-4-chlorobenzofuro [3,2-d] pyrimidine 3. The benzofuro [3,2-d] pyrimidine derivatives (4-12) were prepared by the reaction of compound 3 with aliphatic primary amines, secondary amines and aromatic amines. Synthesized compounds were characterized on the basis of spectral and analytical data. All the compounds were screened for biological activity.

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An efficient synthetic methodology was developed for direct formation of quinazolinones with 2-nitromethyl substituent via 1,1-dichloro-2-nitroethene and anthranilamides. This strategy provides an alternative for quinazolinones construction with merits of proceeding in water, easy purification, and no addition of catalysts.

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Syntheses of 2-chloromethyl-3,4-dihydro-4-oxobenzofuro<3,2-d>pyrimidine (II) and 2-hydroxymethyl-3,4-dihydro-4-oxobenzofuro<3,2-d>pyrimidine (III) and their conversion into 2-chloromethyl-4-chlorobenzofuro<3,2-d>pyrimidine (IV) are reported.Various nucleophilic displacement reactions of II and IV have been investigated.

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