Category: 54802-10-7

54802-10-7, Name is 3-Aminobenzofuran-2-carboxamide, belongs to benzofurans compound, is a common compound. HPLC of Formula: C9H8N2O2In an article, once mentioned the new application about 54802-10-7.

Reaction of 3-aminobenzofuran-2-carboxamide (1) with aromatic aldehydes (2) in acetic acid results in 3-N-(arylideneamino)benzofuran-2-carboxamides (3) and 2-aryl-3,4-dihydro-4-oxobenzofuro<3,2-d>pyrimidines (4) at steam-bath temperature.The reaction at room temperature yields only 3.Dehydrogenative cyclisation of 3 gives 4.

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Benzofuran – Wikipedia,
Benzofuran | C8H2835O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 3-Aminobenzofuran-2-carboxamide, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 54802-10-7, name is 3-Aminobenzofuran-2-carboxamide. In an article，Which mentioned a new discovery about 54802-10-7

A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(beta-alanamido)-benzofuran-2-carboxamide derivatives (5a?o) were synthesized for the purpose of developing the new bioactive chemical entities and evaluated for their in vitro antimicrobial, anti-inflammatory and DPPH radical scavenging activities. The synthesized compounds were characterized by NMR, IR, Mass and X-ray crystallographic techniques.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2828O – PubChem

Synthetic Route of 54802-10-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 54802-10-7, 3-Aminobenzofuran-2-carboxamide, introducing its new discovery.

3-Thio or amino substituted benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted benzofuran-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described. The same benzo[b]thiophene and benzofuran-2-carboxamides also inhibit the activation of human immunodeficiency virus (HIV), latent in infected mammals.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2803O – PubChem

Reference of 54802-10-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.54802-10-7, Name is 3-Aminobenzofuran-2-carboxamide, molecular formula is C9H8N2O2. In a Article，once mentioned of 54802-10-7

Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the GATA4-NKX2-5 transcriptional synergy. Here, the chemical space around the molecular structure of 1 was explored by synthesizing and characterizing 220 derivatives and structurally related compounds. In addition to the synergistic transcriptional activation, selected compounds were evaluated for their effects on transcriptional activities of GATA4 and NKX2-5 individually as well as potential cytotoxicity. The structure-activity relationship (SAR) analysis revealed that the aromatic isoxazole substituent in the southern part regulates the inhibition of GATA4-NKX2-5 transcriptional synergy. Moreover, inhibition of GATA4 transcriptional activity correlated with the reduced cell viability. In summary, comprehensive SAR analysis accompanied by data analysis successfully identified potent and selective inhibitors of GATA4-NKX2-5 transcriptional synergy and revealed structural features important for it.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 54802-10-7

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2825O – PubChem

Synthetic Route of 54802-10-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 54802-10-7, Name is 3-Aminobenzofuran-2-carboxamide, molecular formula is C9H8N2O2. In a Article，once mentioned of 54802-10-7

A series of substituted benzofuropyrimidinones with pan-PIM activities and excellent selectivity against a panel of diverse kinases is described. Initial exploration identified aryl benzofuropyrimidinones that were potent, but had cell permeability limitation. Using X-ray crystal structures of the bound PIM-1 complexes with 3, 5m, and 6d, we were able to guide the SAR and identify the alkyl benzofuropyrimidinone (6l) with good PIM potencies, permeability, and oral exposure.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2838O – PubChem

Reference of 54802-10-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 54802-10-7, Name is 3-Aminobenzofuran-2-carboxamide, molecular formula is C9H8N2O2. In a Patent，once mentioned of 54802-10-7

This invention relates to macrocyclic compounds of formula (I) or (II) shown in the specification. These compounds can be used to treat hepatitis C virus infection.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2805O – PubChem

54802-10-7, Name is 3-Aminobenzofuran-2-carboxamide, belongs to benzofurans compound, is a common compound. Formula: C9H8N2O2In an article, once mentioned the new application about 54802-10-7.

We have developed a KOH-promoted transition-metal-free synthesis of 2-substituted 4(3H)-quinazolinones from anthranilamides and benzyl alcohols or cinnamyl alcohol with air as oxidant. The protocol is simple, practical, and cost saving. Graphical abstract: [Figure not available: see fulltext.]

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2833O – PubChem

Related Products of 54802-10-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 54802-10-7, 3-Aminobenzofuran-2-carboxamide, introducing its new discovery.

The present disclosure provides compounds, methods, and compositions which may be used to treat tuberculosis. In some embodiments, these compounds and compositions have a bactericidal property against Mycobacterium tuberculosis (Mtb). Methods of employing such agents are also provided.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2809O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 54802-10-7, name is 3-Aminobenzofuran-2-carboxamide, introducing its new discovery. Computed Properties of C9H8N2O2

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2813O – PubChem

Related Products of 54802-10-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 54802-10-7, 3-Aminobenzofuran-2-carboxamide, introducing its new discovery.

A high throughput chemical screening campaign has led to the identification of 3-aminobenzo[b]thiophene-2-carboxamides as LIMK1 inhibitors. Evolution of bicyclic hits to the tricyclic 4-aminobenzothieno[3,2-d]pyrimidine, using a traditional medicinal chemistry SAR guided approach, resulted in a significant increase in potency. Further elaboration has seen the 7-phenyl-4- aminobenzothieno[3,2-d]pyrimidine emerge as a LIMK1 inhibitor lead candidate. The Royal Society of Chemistry 2011.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2837O – PubChem