Category: 38183-12-9

Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets was written by Omar, Mahmoud A.;Haredy, Ahmed M.;Saleh, Gamal A.;Naggar, A. H.;Derayea, Sayed M.. And the article was included in Microchemical Journal in 2019.Formula: C17H10O4 This article mentions the following:

Linagliptin (LNG) is a type 2 antidiabetic drug which belongs to dipeptidyl peptidase 4 inhibitors. In this paper a simple and sensitive spectrofluorometric method was developed and validated for the determination of LNG. The method employed the interaction of the primary amino group of the cited drug with fluorescamine reagent in aqueous borate buffer (pH 8.5) to produce a highly fluorescent product. The emission of the formed product was measured at 479 nm after excitation at 390 nm. Different exptl. parameters that may affect the product formation or its fluorescence intensity were investigated and adjusted. The method has a good linearity in the concentration range of 0.2 – 2.0 μg mL^-1of LNG with a detection limit of 0.079 μg mL^-1. The performance of the developed method was evaluated according to the International Conference for Harmonization (ICH). The method was successfully applied for the anal. of tablets dosage form that contained the cited drug. The results of the anal. were compared with the reported method and indicated good accuracy and precision of the proposed procedure. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Free-Standing Self-Assembled Tubular Conjugated Polymer Sensor was written by Oh, Seungwhan;Uh, Kyungchan;Jeon, Seongho;Kim, Jong-Man. And the article was included in Macromolecules (Washington, DC, United States) in 2016.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Tubular materials created by self-assembly of small organic mols. have gained great attention recently. Fabrication of tubular structures that have precise dimensions by using conventional self-assembly approaches is extremely challenging. Herein we describe fabrication of a free-standing tubular polydiacetylene (PDA) sensor based on the meniscus-guided self-assembly and polymerization of diacetylene (DA) monomers. The free-standing single PDA tube can be utilized as an unprecedented microcapillary-based sensor system, which requires only a min. amount (70-140 nL) of an analyte solution We have observed 4 orders of magnitude more sensitive to analytes than is a conventional PDA sensor when a biotin-functionalized PDA tube is exposed to streptavidin. The microcapillary-based anal. method developed in this study should find great utility not only for PDA sensors but also for other free-standing wire sensor systems. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enzymatic vitreolysis using reengineered Vibrio mimicus-derived collagenase was written by Santra, Mithun;Sharma, Maryada;Katoch, Deeksha;Jain, Sahil;Saikia, Uma Nahar;Dogra, Mangat R.;Luthra-Guptasarma, Manni. And the article was included in Molecular Vision in 2021.Reference of 38183-12-9 This article mentions the following:

Collagen is a key player contributing to vitreoelasticity and vitreoretinal adhesions. Mol. reorganization causes spontaneous weakening of these adhesions with age, resulting in the separation of the posterior hyaloid membrane (PHM) from the retina in what is called complete posterior vitreous detachment (PVD). Incomplete separation of the posterior hyaloid or tight adherence or both can lead to retinal detachment, vitreomacular traction syndrome, or epiretinal membrane formation, which requires surgical intervention. Pharmacol. vitrectomy has the potential of avoiding surgical vitrectomy; it is also useful as an adjunct during retinal surgery to induce PVD. Previously studied enzymic reagents, such as collagenase derived from Clostridium histolyticum, are nonspecific and potentially toxic. We studied a novel collagenase from Vibrio mimicus (VMC) which remains active (VMA), even after deletion of 51 C-terminal amino acids. To limit the activity of VMA to the vitreous cavity, a fusion construct (inhibitor of hyaluronic acid-VMA [iHA-VMA]) was made in which a 12-mer peptide (iHA, which binds to HA) was fused to the N-terminus of VMA. The construct was evaluated in the context of PVD. VMA and iHA-VMA were expressed in Escherichia coli, purified, and characterized with gelatin zymog., collagen degradation assay, fluorescamine-based assay, and cell-based assays. Two sets of experiments were performed in New Zealand albino rabbits. Group A (n = 10) received iHA-VMA, while group B (n = 5) received the equivalent dose of VMA. In both groups, saline was injected as a control in the contralateral eyes. Animals were monitored with indirect ophthalmoscopy, optical coherence tomog. (OCT), and B-scan ultrasonog. Retinal toxicity was assessed with hematoxylin and eosin (H&E) staining of retinal tissue. The activity of iHA-VMA and VMA was comparable and 65-fold lower than that of C. histolyticum collagenase Type IV. In the iHA-VMA group, all the rabbits (n = 10) developed PVD, with complete PVD seen in six animals. No statistically significant histomorphol. changes were seen. In the VMA group, four of the five rabbits developed complete PVD; however, retinal morphol. changes were seen in two animals. IHA-VMA displays targeted action confined to the vitreous and shows potential for safe pharmacol. vitreolysis. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Electrochemical Detection of Ammonia in Aqueous Solution Using Fluorescamine: A Comparison of Fluorometric Versus Voltammetric Analysis was written by Panchompoo, Janjira;Compton, Richard G.. And the article was included in Dianhuaxue in 2012.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Fluorescamine is a non-fluorescent reagent widely used for the quant. determination o f primary amines by fluorescence spectroscopy as it reacts readily with primary amines to form a fluorescent product. In this work, a new sensitive voltammetric method for the detection of ammonia in aqueous solution by the reaction with fluorescamine was developed. First, the electrochem. behavior of fluorescamine in the absence and presence o f ammonia was investigated in 0.1 mol·L^-1 borate buffer solution (pH 9.0) by cyclic voltammetry using a glassy carbon (GC) electrode. As for fluorescamine itself, a well-defined irreversible oxidation peak could be observed at ∼0.70 V vs. SCE. When ammonia was added to the fluorescamine solution, another irreversible oxidation peak corresponding to the oxidation o f the reaction product formed between fluorescamine and ammonia could be observed at ∼0.46 V vs. SCE. Upon the addition of ammonia, the oxidation peak o f fluorescamine became smaller while the oxidation peak o f the reaction product formed increased in height, due to the stoichiometric chem. consumption o f fluorescamine by ammonia and the formation o f the product during the reaction, resp. These two anodic peaks corresponding to the oxidation of fluorescamine and its fluorescent product formed were then used for the quant. detection o f ammonia, explored by square wave voltammetry and by fluorescence spectroscopy. The square wave voltammetric response o f the reaction product formed showed a linear response over ammonia concentration range o f 0 to 60 μmol-L^-1. The limits o f detection (LOD) was 0.71 μmol·L^-1 and 3.17 μmol-L^-1 determined based upon Signal/Noise (S/N) = 3 and 3cr, resp. These limits o f detection are similar to those obtained with the fluorometric method. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Salvage parenteral antibiotics for multidrug-resistant (MDR) Gram-negative bacteria; a fluorescamine-based technique for ultrasensitive spectrofluorimetric measurement of Polymyxins; human plasma application was written by Badr El-Din, Khalid M.;Abdelmajed, Mahmoud A.;Omar, Mahmoud A.;Attia, Tamer Z.. And the article was included in Luminescence in 2022.Computed Properties of C17H10O4 This article mentions the following:

Polymyxins (PMS), namely Colistin (CS) and polymyxin B (poly B), are antimicrobial drugs that have been recently used to treat multiresistant Gram-neg. bacteria infections and their resurgence, owing to a lack of new antibiotics. A speedy, simple, and ultrasensitive spectrofluorimetric screening of PMS in pharmaceutical formulations and biol. fluids was urgently required from this point forwards. A reaction between fluorescamine and the aliphatic amino moiety found in both drugs was performed in a slightly alk. borate buffer (pH 8.5) resulted in highly fluorescent products measured at λ_em 460 (after λ_ex 390.5 nm). Linear calibration curves were constructed over the concentration range 70-1800 ng ml^-1 and 100 to 1400 ng ml^-1, with slope values of 0.273 and 0.286, correlation coefficients of 0.9998 and 0.9997, and determination coefficient of 0.9997 and 0.9994 for poly B and CS, resp. The ultrasensitivity of the proposed method was demonstrated by the very low limit of quantification values of 67.56 ng ml^-1 and 94.89 ng ml^-1 for poly B and CS, resp. The cited drugs were successfully determined in their i.v. market preparations by the prescribed method. Moreover, due to the high sensitivity, the suggested method was used to assay the investigated drugs in biol. fluids. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Computed Properties of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Computed Properties of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity was written by Macuamule, Cristiano J.;Tjhin, Erick T.;Jana, Collins E.;Barnard, Leanne;Koekemoer, Lizbe;de Villiers, Marianne;Saliba, Kevin J.;Strauss, Erick. And the article was included in Antimicrobial Agents and Chemotherapy in 2015.Category: benzofurans This article mentions the following:

Pantothenamides inhibit blood-stage Plasmodium falciparum with potencies (50% inhibitory concentration [IC50], ∼20 nM) similar to that of chloroquine. They target processes dependent on pantothenate, a precursor of the essential metabolic cofactor CoA. However, their antiplasmodial activity is reduced due to degradation by serum pantetheinase. Minor modification of the pantothenamide structure led to the identification of α-methyl-N-phenethyl-pantothenamide, a pantothenamide resistant to degradation, with excellent antiplasmodial activity (IC50, 52 ± 6 nM), target specificity, and low toxicity. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Category: benzofurans).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A sequential injection fluorimetric methodology with in-line solid phase extraction for biogenic amines screening in water was written by Ribas, Tania C. F.;Toth, Ildiko V.;Rangel, Antonio O. S. S.. And the article was included in International Journal of Environmental Analytical Chemistry in 2019.Reference of 38183-12-9 This article mentions the following:

A method for the screening of biogenic amines in waters, whose presence at some concentration levels potentially cause adverse effects on humans, was developed for the first time. A suitable and easy to operate system, with low reagent consumption was devised. The proposed flow-based system was divided into two anal. parts, preconcentration and derivatization of the biogenic amines. Solid phase extraction, using a Chelex 100 resin, was the newly chosen strategy for preconcentration of the analyte and also removal of possible matrix interferences. Fluorescamine was used as derivatization reagent for biogenic amines followed by fluorimetric detection. The influence of different sorbent materials for preconcentration and flow system parameters such as pH of standards and buffer, composition of the eluent solution, flow-rates, standard/sample volume, were studied. The interference of ammonia was assessed, and no interference was observed The limits of detection and quantification were 1.7 and 5.6μmol L^-1, resp. The developed system was applied to water samples and the recovery results were 98 ± 7%. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Titration of lysine residues on adenine nucleotide translocase by fluorescamine induces permeability transition was written by Buelna-Chontal, Mabel;Pavon, Natalia;Correa, Francisco;Hernandez-Esquivel, Luz;Chavez, Edmundo. And the article was included in Cell Biology International in 2014.HPLC of Formula: 38183-12-9 This article mentions the following:

Chem. modification of primary amino groups of mitochondrial membrane proteins by the fluorescent probe, fluorescamine (I), induced nonspecific membrane permeabilization. Titration of the Lys ε-amino group promoted efflux of accumulated Ca²⁺, collapse of transmembrane potential, and mitochondrial swelling. Ca²⁺ release was inhibited by cyclosporin A. Considering the latter, the authors assumed that I induced the permeability transition. Carboxyatractyloside also inhibited the reaction. Using a polyclonal antibody for adenine nucleotide translocase, Western blot anal. showed that the carrier appeared labeled with I. The results pointed out the importance of the ε-amino group of Lys residues, located in the adenine nucleotide carrier, on the modulation of membrane permeability, since its blockage suffices to promote opening of the nonspecific nanopore. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computational Predictions of Glass-Forming Ability and Crystallization Tendency of Drug Molecules was written by Alhalaweh, Amjad;Alzghoul, Ahmad;Kaialy, Waseem;Mahlin, Denny;Bergstroem, Christel A. S.. And the article was included in Molecular Pharmaceutics in 2014.Recommanded Product: 38183-12-9 This article mentions the following:

Amorphization is an attractive formulation technique for drugs suffering from poor aqueous solubility as a result of their high lattice energy. Computational models that can predict the material properties associated with amorphization, such as glass-forming ability (GFA) and crystallization behavior in the dry state, would be a time-saving, cost-effective, and material-sparing approach compared to traditional exptl. procedures. This article presents predictive models of these properties developed using support vector machine (SVM) algorithm. The GFA and crystallization tendency were investigated by melt-quenching 131 drug mols. in situ using differential scanning calorimetry. The SVM algorithm was used to develop computational models based on calculated mol. descriptors. The analyses confirmed the previously suggested cutoff mol. weight (MW) of 300 for glass-formers, and also clarified the extent to which MW can be used to predict the GFA of compounds with MW < 300. The topol. equivalent of Grav3_3D, which is related to mol. size and shape, was a better descriptor than MW for GFA; it was able to accurately predict 86% of the data set regardless of MW. The potential for crystallization was predicted using mol. descriptors reflecting Hückel pi at. charges and the number of hydrogen bond acceptors. The models developed could be used in the early drug development stage to indicate whether amorphization would be a suitable formulation strategy for improving the dissolution and/or apparent solubility of poorly soluble compounds In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In-capillary derivatization with fluorescamine for the rapid determination of adamantane drugs by capillary electrophoresis with UV detection was written by Prapatpong, Pornpan;Nuchtavorn, Nantana;Macka, Mirek;Suntornsuk, Leena. And the article was included in Journal of Separation Science in 2018.Synthetic Route of C17H10O4 This article mentions the following:

In-capillary derivatization using fluorescamine as the labeling reagent was proposed to enhance the detectability of adamantine drugs (memantine, amantadine, rimantadine) by spectrophotometric detection. Fluorescamine and the drugs were delivered to the capillary electrophoresis instrument at a ratio of 10:1 by zone injection. The derivatization reaction occurred following the application of voltage (20 kV). The derivatized products, hydrolyzed- fluorescamine and excess fluorescamine were separated in 7 min using 100 mM borate buffer (pH 10.0) containing 0.1% w/v of Brij-35 and 20% volume/volume of acetonitrile. Validation data showed good linearity (r² > 0.98), precision (%RSDs < 3.4), and accuracy (recoveries ranging from 98.0 to 102.0%). The detection and quantitation limits were in the range of 6.0-8.5 and 18-25 μM, resp. The validation data were comparable to reported methods, however, the current method offers better precision with enhanced sensitivity (up to six times). Applications of the method show percent labeled amounts found in the studied samples within 100.6-109.3%, which complied with the USP limit (90.0-110.0%). The method was simple, rapid and automated, and requires no extra instrumentation or skillful operators. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem