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1-phenyl-3 -dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3288O – PubChem

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Visible light-induced monofluoromethylenation of benzofurans and benzothiophenes with ethyl bromofluoroacetate was developed. This method provided a convenient access to novel alpha-fluoro-alpha-heteroarylesters under mild reaction conditions.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3316O – PubChem

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We have developed a nickel-catalyzed hydroarylation of alkenes using aryl halides as coupling partners. Excellent anti-Markovnikov selectivity is achieved with aryl-substituted alkenes and enol ethers. We also show that hydroarylation occurs with alkyl substituted alkenes to yield linear products. Preliminary examination of the reaction mechanism suggests irreversible hydrometallation as the selectivity determining step of the hydroarylation.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3305O – PubChem

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The present invention provides a vertical he si te intermediate I preparation method, in order to 6 – bromophenylacetic and furan as the starting material, in the n-butyl lithium – under the action of the halogen exchange reaction, then with the dimethyl carbonate by the reaction of the 6 – methyl benzofuran, after hydrolysis to obtain vertical he si te intermediate I. The raw materials are easily obtained, less reaction by-product, high yield, high purity of the final product, at the same time steps (1) and step (2) can be a pot of reaction, the reaction step is simplified, and the mild reaction conditions, the product does not need separation eluent, easy to realize industrial. (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3293O – PubChem

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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C8H5BrO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 128851-73-0, in my other articles.

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Provided herein are compounds of Formula (I), or a stereoisomer, a geometric isomer, an enantiomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which are used in the treatment of HCV infection or hepatitis C. Provided herein also are pharmaceutical compositions containing such compounds and methods of using the compound of the present invention or pharmaceutical compositions thereof to treat HCV infection or hepatitis C.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3294O – PubChem

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This contribution reports results from the gas-phase oxidation of 4-bromo-4′-chlorobiphenyl (4,4′-BCB) in order to fathom the formation of toxic species produced during the combustion of mixed halogenated aromatics. In their own right, mixed polybrominated/polychlorinated biphenyls (PXBs) represent a new class of environmental contaminants, recently detected in food and human tissues. Gas chromatography-quadrupole mass spectrometry (GC-QMS), gas chromatography-quadrupole time of flight mass spectrometry (GC-QTOFMS), Fourier transform infrared spectroscopy (FTIR) and ion chromatography (IC) served to analyse the volatile and semi-volatile organic compounds (V/SVOCs), including mixed halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs), and gaseous products including HBr/HCl. The selection of non-ortho substituted PXB as a model species yields a large number of halogenated compounds, including monochloro- and monobromobenzene and higher halogenated benzenes and naphthalenes and derivatives of halogenated benzenes (such as 1-chloro-4-ethynylbenzene). We also detect small amounts of chlorinated and mixed halogenated dibenzofurans. The present study provides insights into the formation of several classes of halogenated and mixed-halogenated pollutants in combustion processes involving both bromine and chlorine sources, such as those of brominated flame retardants and PVC plastics.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3300O – PubChem

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128851-73-0, Name is 6-Bromobenzofuran, belongs to benzofurans compound, is a common compound. Quality Control of 6-BromobenzofuranIn an article, once mentioned the new application about 128851-73-0.

Janus kinases inhibitor is considered to have therapeutic potential for the treatment of oncology and immune-inflammatory diseases. Two series of 4-(2-benzofuranyl)pyrimidin-2-amine and 4-(4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-yl)pyrimidin-2-amine derivatives have been designed and synthesized. Primary SAR studies resulted in the discovery of a novel class of 4,5,6,7-tetrahydrofuro[3,2-c]pyridine based JAK2 inhibitors with higher potency (IC50of 0.7 nM) and selectivity (>30 fold) to JAK3 kinase than tofacitinib.

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Benzofuran – Wikipedia,
Benzofuran | C8H3312O – PubChem

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The benzodioxole ((methylenedioxy)benzene) group is present in a number of endothelin (ET) receptor antagonists thus far reported. As part of our own endothelin antagonist program we have developed (2R*,3R*,4S*)-1-(N,N- dibutylacetamido)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidine-3- carboxylic acid (A-127722). This is a potent antagonist, binding to the ET(A) and ET(B) receptor subtypes with affinities (IC50) of 0.4 and 520 nM, respectively, and also contains the aforementioned benzodioxole. While this compound was seemingly optimized at its N-terminus, no effort had been directed toward understanding the contributions to binding affinity or receptor subtype selectivity conferred by the benzodioxole. Substitution by 1- or 2-naphthyl yielded weak antagonists. Oxygenated benzenes, such as p- anisyl, were potent compounds with IC50s in the low-nanomolar range. Simple deletion of either of the two oxygen atoms (dihydrobenzofurans) yielded extremely potent agents, possessing subnanomolar affinity for the ET(A) receptor. Additionally, the compounds showed enhanced selectivity, binding to the ET(B) receptor subtype in the micromolar range. This paper describes the development of this novel class of compounds.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3309O – PubChem

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The synthesis and structure-activity relationships of a series of 5,7-diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acids are described. Our efforts have been focused on modification of the aryl ring at the 5-position and the alkyl substituent at the 2-position of the bottom 4-methoxyphenyl ring in an effort to develop orally available ETA selective antagonists with safer profiles in terms of the P-450 enzyme inhibitory activity. Incorporation of a hydroxymethyl group as an alkyl substituent in methylenedioxyphenyl and 6-dihydrobenzofuran derivatives led to the identification of orally bioavailable ETA selective antagonists 1f and 7f. These compounds also showed not only excellent binding affinity (IC50<0.10nM, more than 800-fold selectivity for the ETA receptor over the ETB receptor) but also sufficient oral bioavailability, 48% and 56%, respectively, in rats. Furthermore, these compounds did not exhibit either competitive or mechanism-based inhibition of human cytochrome P450 enzymes. If you are interested in 128851-73-0, you can contact me at any time and look forward to more communication. Computed Properties of C8H5BrO

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3315O – PubChem

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The synthesis of a series of substituted benzofurans is reported. Selected compounds have been shown to bind strongly and with high selectivity to the serotonin receptor 5-HT2A in the presence of the receptor 5-HT 7 in vitro.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3301O – PubChem