128851-73-0, Name is 6-Bromobenzofuran, belongs to benzofurans compound, is a common compound. Quality Control of 6-BromobenzofuranIn an article, once mentioned the new application about 128851-73-0.
Janus kinases inhibitor is considered to have therapeutic potential for the treatment of oncology and immune-inflammatory diseases. Two series of 4-(2-benzofuranyl)pyrimidin-2-amine and 4-(4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-yl)pyrimidin-2-amine derivatives have been designed and synthesized. Primary SAR studies resulted in the discovery of a novel class of 4,5,6,7-tetrahydrofuro[3,2-c]pyridine based JAK2 inhibitors with higher potency (IC50of 0.7 nM) and selectivity (>30 fold) to JAK3 kinase than tofacitinib.
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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3312O – PubChem