Category: 128851-73-0

Application of 128851-73-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 128851-73-0, Name is 6-Bromobenzofuran,introducing its new discovery.

The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3304O – PubChem

Synthetic Route of 128851-73-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 128851-73-0, Name is 6-Bromobenzofuran, molecular formula is C8H5BrO. In a Patent£¬once mentioned of 128851-73-0

Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists

The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R1, R2, R3, R4, R4?, R5, R5?, and R12 are as described in the specification.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3283O – PubChem

Reference of 128851-73-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 128851-73-0, 6-Bromobenzofuran, introducing its new discovery.

Photoredox-Catalysis-Modulated, Nickel-Catalyzed Divergent Difunctionalization of Ethylene

Divergent synthesis that enables a catalytic reaction to selectively produce different products from common substrates will allow the charting of wider chemical space and the unveiling of distinct mechanistic paradigms. A common strategy for it employs different ligands to modulate organometallic catalysts. Dramatic developments in photocatalysis have enabled previously inaccessible transformations. In particular, photoredox catalysis modulates the oxidation state of transition-metal complexes, offering enormous opportunities for methodology development. Herein, we developed a photo-mediated divergent ethylene difunctionalization via modulating oxidation states of the nickel catalyst by using different photoredox catalysts. This work will inspire new perspectives for value-added chemical synthesis using ethylene as a feedstock and shed light on photoredox-catalyst-based divergent synthesis, which fundamentally differs from ligand-controlled transition-metal catalysis.Divergent synthesis represents a powerful strategy for directly accessing different molecular scaffolds originating from the same starting materials. Access to different end products via transition-metal catalysis is conventionally achieved by ligand control. We herein demonstrate the use of ethylene feedstock and commercially available aryl halides to accomplish the divergent synthesis of 1,2-diarylethanes, 1,4-diarylbutanes, or 2,3-diarylbutanes in a highly selective fashion through the synergistic combination of nickel and photoredox catalysis. Mechanistic studies suggest that the observed selectivity was due to different active states of Ni(I) and Ni(0) modulated by Ru- and Ir-based photoredox catalysts, respectively. The ability to access different organometallic oxidation states via photoredox catalysis promises to inspire new perspectives for synergistic transition-metal-catalyzed divergent synthesis.Functionalization of ethylene without polymerization is challenging under photo-irradiation conditions. We have demonstrated that the photo-transformation of ethylene can be controllable by merging photoredox and transition-metal catalysis. In our study, the use of different photoredox catalysts was able to modulate the oxidation state of the nickel catalyst. Through different oxidation states, the nickel-catalyzed couplings proceeded via distinct pathways to generate divergent ethylene difunctionalization products selectively from the same feedstock.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3302O – PubChem

Electric Literature of 128851-73-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 128851-73-0, Name is 6-Bromobenzofuran, molecular formula is C8H5BrO. In a Patent£¬once mentioned of 128851-73-0

1-phenyl-3-dimethylaminopropane compounds with a pharmacological effect

1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3287O – PubChem

Electric Literature of 128851-73-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 128851-73-0, Name is 6-Bromobenzofuran,introducing its new discovery.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3280O – PubChem

Synthetic Route of 128851-73-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 128851-73-0, Name is 6-Bromobenzofuran,introducing its new discovery.

Pyrimidine or pyrazine ring compound and application thereof (by machine translation)

The invention also provides a preparation method of the compound, a composition, containing the compound and a pharmaceutical application, of, the compound, a composition containing the compound .and the compound in preparation of a pharmaceutical application for treating, diseases or disorders related to the action mechanism of the protein complex action EED of the/protein PRC2 and the protein. (by machine translation)

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3297O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 6-Bromobenzofuran, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 128851-73-0, Name is 6-Bromobenzofuran, molecular formula is C8H5BrO

Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections

Blocking the staphyloxanthin biosynthesis process has emerged as a new promising antivirulence strategy. Previously, we first revealed that CrtN is a druggable target against infections caused by pigmented Staphylococcus aureus (S. aureus) and that naftifine was an effective CrtN inhibitor. Here, we identify a new type of benzofuran-derived CrtN inhibitor with submicromolar IC50 values that is based on the naftifine scaffold. The most potent analog, 5m, inhibits the pigment production of S. aureus Newman and three MRSA strains, with IC50 values of 0.38-5.45 nM, without any impact on the survival of four strains (up to 200 muM). Notably, compound 5m (1 muM) could significantly sensitize four strains to immune clearance and could effectively attenuate the virulence of three strains in vivo. Moreover, 5m was determined to be a weak antifungal reagent (MIC > 16 mug/mL). Combined with good oral bioavailability (F = 42.2%) and excellent safety profiles, these data demonstrate that 5m may be a good candidate for the treatment of MRSA infections.

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Benzofuran – Wikipedia,
Benzofuran | C8H3313O – PubChem

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Base-Mediated Meerwein-Ponndorf-Verley Reduction of Aromatic and Heterocyclic Ketones

An experimental protocol to achieve the Meerwein-Ponndorf-Verley (MPV) reduction of ketones under mildly basic conditions is reported. The transformation is tolerant of a range of ketone substrates, including O- and S-containing heterocycles, is scalable, and shows potential to be used as a platform to access enantioenriched products. These studies provide a general method for achieving the reduction of ketones under mildly basic conditions and offer an alternative protocol to more well-known Al-based MPV reduction conditions.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3299O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 6-Bromobenzofuran, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 128851-73-0, Name is 6-Bromobenzofuran, molecular formula is C8H5BrO

SEROTONERGIC BENZOFURANS

The present invention provides serotonergic benzofurans of Formula (I): where A, R, R1, R2, R3, and R4 are as described in the specification.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3284O – PubChem

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Zeolite-catalyzed synthesis of 2,3-unsubstituted benzo[b]furans via the intramolecular cyclization of 2-aryloxyacetaldehyde acetals

An efficient and environmentally benign heterogeneous catalytic process for the synthesis of 2,3-unsubstituted benzo[b]furans has been established via the intramolecular cyclization of 2-aryloxyacetaldehyde acetals. By utilizing tin-exchanged H-beta zeolite (Sn-beta) as catalyst, a wide range of functionalized 2,3-unsubstituted benzo[b]furans could be prepared in good to excellent yields. The Sn-beta zeolite catalyst also exhibited excellent shape selectivity on the cyclization of meta-substituted 2-aryloxyacetaldehyde acetals, and 6-substituted isomers were preferably formed up to 97% regio-selectivity. Moreover, Sn-beta zeolite could be easily recovered and reused without any noticeable activity loss.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3308O – PubChem