Category: 1083168-69-7

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 1083168-69-7. Introducing a new discovery about 1083168-69-7, Name is (2,3-Dihydrobenzofuran-6-yl)methanol

Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model

A series of 2-alkylamino nicotinamide analogs was prepared as orally active ghrelin receptor (ghrelinR) inverse agonists. Starting from compound 1, oral bioavailability was improved by modifying metabolically unstable sites and reducing molecular weight. Brain-permeable compound 33 and compound 24 with low brain permeability were tested in rat models of obesity; 30 mg/kg of compound 33 suppressed weight gain. PK/PD analysis revealed that the anti-obesity effect of ghrelinR inverse agonists depends on their brain concentrations.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 1083168-69-7, you can also check out more blogs about1083168-69-7

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Benzofuran – Wikipedia,
Benzofuran | C8H1521O – PubChem

1083168-69-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1083168-69-7, molcular formula is C9H10O2, introducing its new discovery.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“”ABC””) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“”CFTR””). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 1083168-69-7, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1083168-69-7

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Benzofuran – Wikipedia,
Benzofuran | C8H1520O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1083168-69-7,(2,3-Dihydrobenzofuran-6-yl)methanol,as a common compound, the synthetic route is as follows.

A solution of 8 (2.38 g, 15.8 mmol) in CH2Cl2 (15.8 mL) was cooled with ice bath and SOCl2 (9.44 g, 79 mmol) was added dropwise. The mixture was stirred at room temperature for 1 h and concentrated in vacuo. The residue was stirred with phthalimide potassium salt (3.23 g, 17.4 mmol) and DMF (15.8 mL) at 90 C for 2 h and cooled, then partitioned between AcOEt (80 mL) and water (60 mL). The aqueous phase was extracted with AcOEt and the combined organic phase was washed with brine and 1 N NaOH, then dried over MgSO4 and filtered. After removal of the solvent in vacuo, the residue was recrystallized from MeOH (58 mL) and AcOEt (27 mL) to obtain 9 as a red solid (3.07 g, 69%). 1H NMR (400 MHz, CDCl3) delta = 7.84 (d, J = 8.4 Hz, 2H), 7.70 (d, J = 8.4 Hz, 2H), 7.11 (d, J = 8.0 Hz, 1H), 6.91 (dd, J = 1.6, 7.6 Hz, 1H), 6.84 (d, J = 1.6 Hz, 1H), 4.79 (s, 2H), 4.53 (t, J = 8.8 Hz, 2H), 3.15 (t, J = 8.8 Hz, 2H); MS (ESI+) 280.2 (M+H)+.

1083168-69-7, The synthetic route of 1083168-69-7 has been constantly updated, and we look forward to future research findings.

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Article; Takahashi, Bitoku; Funami, Hideaki; Iwaki, Takehiko; Maruoka, Hiroshi; Shibata, Makoto; Koyama, Makoto; Nagahira, Asako; Kamiide, Yoshiyuki; Kanki, Satomi; Igawa, Yoshiyuki; Muto, Tsuyoshi; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4792 – 4803;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1083168-69-7,(2,3-Dihydrobenzofuran-6-yl)methanol,as a common compound, the synthetic route is as follows.

Step g: 6-(Chloromethyl)-2,3-dihydrobenzofuran; To a solution of (2,3-dihydrobenzofuran-6-yl)methanol (13.8 g, 92mmol) inCHCl3 (200 mL) was slowly added SOCl2 at 0C. The reaction mixture was stirred at reflux for 4h. After the solvent was removed, saturated NaHCO3 and ethyl acetate were added to the mixture. The organic layer was extracted with ethyl acetate. The combined organic layer was then washed with brine and dried over Na2SO4, filtered and concentrated to afford 6- (chloromethyl)-2,3-dihydrobenzofuran (12.3 g, 80.0% yield). 1H NMR (400 MHz, CDCl3) delta: 7.16 (d, J= 7.5, IH), 6.87 (d, J= 7.5, IH), 6.83 (s, IH), 4.58 (t, J= 8.7, 2H), 4.49 (s, 2H), 3.20 (t, J= 8.7, 2H)., 1083168-69-7

1083168-69-7 (2,3-Dihydrobenzofuran-6-yl)methanol 18356898, abenzofuran compound, is more and more widely used in various fields.

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Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/141119; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem