With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1083168-69-7,(2,3-Dihydrobenzofuran-6-yl)methanol,as a common compound, the synthetic route is as follows.
Step g: 6-(Chloromethyl)-2,3-dihydrobenzofuran; To a solution of (2,3-dihydrobenzofuran-6-yl)methanol (13.8 g, 92mmol) inCHCl3 (200 mL) was slowly added SOCl2 at 0C. The reaction mixture was stirred at reflux for 4h. After the solvent was removed, saturated NaHCO3 and ethyl acetate were added to the mixture. The organic layer was extracted with ethyl acetate. The combined organic layer was then washed with brine and dried over Na2SO4, filtered and concentrated to afford 6- (chloromethyl)-2,3-dihydrobenzofuran (12.3 g, 80.0% yield). 1H NMR (400 MHz, CDCl3) delta: 7.16 (d, J= 7.5, IH), 6.87 (d, J= 7.5, IH), 6.83 (s, IH), 4.58 (t, J= 8.7, 2H), 4.49 (s, 2H), 3.20 (t, J= 8.7, 2H)., 1083168-69-7
1083168-69-7 (2,3-Dihydrobenzofuran-6-yl)methanol 18356898, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/141119; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem