With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1083168-69-7,(2,3-Dihydrobenzofuran-6-yl)methanol,as a common compound, the synthetic route is as follows.
A solution of 8 (2.38 g, 15.8 mmol) in CH2Cl2 (15.8 mL) was cooled with ice bath and SOCl2 (9.44 g, 79 mmol) was added dropwise. The mixture was stirred at room temperature for 1 h and concentrated in vacuo. The residue was stirred with phthalimide potassium salt (3.23 g, 17.4 mmol) and DMF (15.8 mL) at 90 C for 2 h and cooled, then partitioned between AcOEt (80 mL) and water (60 mL). The aqueous phase was extracted with AcOEt and the combined organic phase was washed with brine and 1 N NaOH, then dried over MgSO4 and filtered. After removal of the solvent in vacuo, the residue was recrystallized from MeOH (58 mL) and AcOEt (27 mL) to obtain 9 as a red solid (3.07 g, 69%). 1H NMR (400 MHz, CDCl3) delta = 7.84 (d, J = 8.4 Hz, 2H), 7.70 (d, J = 8.4 Hz, 2H), 7.11 (d, J = 8.0 Hz, 1H), 6.91 (dd, J = 1.6, 7.6 Hz, 1H), 6.84 (d, J = 1.6 Hz, 1H), 4.79 (s, 2H), 4.53 (t, J = 8.8 Hz, 2H), 3.15 (t, J = 8.8 Hz, 2H); MS (ESI+) 280.2 (M+H)+.
1083168-69-7, The synthetic route of 1083168-69-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Takahashi, Bitoku; Funami, Hideaki; Iwaki, Takehiko; Maruoka, Hiroshi; Shibata, Makoto; Koyama, Makoto; Nagahira, Asako; Kamiide, Yoshiyuki; Kanki, Satomi; Igawa, Yoshiyuki; Muto, Tsuyoshi; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4792 – 4803;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem