Month: February 2023

Peptide controlled assembly of palladium nanoparticles on high-aspect-ratio gold nanorods was written by Wagner, John Tyler;Long, Analeece K.;Sumner, Michael B. III;Cockman, Ivan;Smith, Marvin;Penland, Beverly Briggs. And the article was included in Journal of Physical Chemistry C in 2020.Related Products of 38183-12-9 This article mentions the following:

The use of gold nanorods as a template for bimetallic applications, including plasmonics, imaging, and phototherapy, is widely studied due to the unique optical properties of the gold materials. Generally, gold nanorods prepared with a Ag-assisted method are used, with a typical aspect ratio (length vs. width) around 3, resulting in surface plasmons resonating within the UV-visible range. Due to these unique properties, gold nanorods are often combined with a catalytically active second metal to increase their range of applicability. The use of higher-aspect-ratio gold nanorods as a bimetallic template is an attractive alternative to the typical method as the longitudinal plasmon of these materials can be adjusted into the near-IR (NIR) range. This adjustment expands the applications of bimetallic Au nanorods in the second-NIR biol. window, which spans 1000-1700 nm. A materials-binding peptide, CPd4, is used to control the size and shape formation of palladium nanoparticles onto the surface of high-aspect-ratio gold nanorods. Through variation of the solvent used when attaching the peptide, the concentration of CPd4 retained on the nanorods can be manipulated. Higher concentrations of peptide, once palladium was added, were seen to result in smaller cubelike nanoparticles on the surface, whereas lower concentrations of peptide yielded larger spherical palladium nanoparticles. The ability to tune the size and shape of palladium nanorods on the gold nanorod surface allows for optimization of catalytic activity with applications in the NIR range. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Related Products of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Related Products of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors was written by Duan, Xiaopin;Chan, Christina;Han, Wenbo;Guo, Nining;Weichselbaum, Ralph R.;Lin, Wenbin. And the article was included in Nature Communications in 2019.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Nanoparticles can potentially stimulate tumor microenvironments to elicit antitumor immunity. Herein, we demonstrate effective immunotherapy of colorectal cancer via systemic delivery of an immunostimulatory chemotherapeutic combination in nanoscale coordination polymer (NCP) core-shell particles. Oxaliplatin and dihydroartemesinin have contrasting physicochem. properties but strong synergy in reactive oxygen species (ROS) generation and anticancer activity. The combined ROS generation is harnessed for immune activation to synergize with an anti-PD-L1 antibody for the treatment of murine colorectal cancer tumors. The favorable biodistribution and tumor uptake of NCPs and the absence of peripheral neuropathy allow for repeated dosing to afford 100% tumor eradication. The involvement of innate and adaptive immune systems elicit strong and long lasting antitumor immunity which prevents tumor formation when cured mice are challenged with cancer cells. The intrinsically biodegradable, well tolerated, and systemically available immunostimulatory NCP promises to enter clin. testing as an immunotherapy against colorectal cancer. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Atmospheric conditions and composition that influence PM_2.5 oxidative potential in Beijing, China was written by Campbell, Steven J.;Wolfer, Kate;Utinger, Battist;Westwood, Joe;Zhang, Zhi-Hui;Bukowiecki, Nicolas;Steimer, Sarah S.;Vu, Tuan V.;Xu, Jingsha;Straw, Nicholas;Thomson, Steven;Elzein, Atallah;Sun, Yele;Liu, Di;Li, Linjie;Fu, Pingqing;Lewis, Alastair C.;Harrison, Roy M.;Bloss, William J.;Loh, Miranda;Miller, Mark R.;Shi, Zongbo;Kalberer, Markus. And the article was included in Atmospheric Chemistry and Physics in 2021.Related Products of 76-54-0 This article mentions the following:

Epidemiol. studies have consistently linked exposure to PM_2.5 with adverse health effects. The oxidative potential (OP) of aerosol particles has been widely suggested as a measure of their potential toxicity. Several acellular chem. assays are now readily employed to measure OP; however, uncertainty remains regarding the atm. conditions and specific chem. components of PM_2.5 that drive OP. A limited number of studies have simultaneously utilized multiple OP assays with a wide range of concurrent measurements and investigated the seasonality of PM_2.5 OP. In this work, filter samples were collected in winter 2016 and summer 2017 during the atm. pollution and human health in a Chinese megacity campaign (APHHBeijing), and PM_2.5 OP was analyzed using four acellular methods: ascorbic acid (AA), dithiothreitol (DTT), 2,7- dichlorofluorescin/hydrogen peroxidase (DCFH) and ESR spectroscopy (EPR). Each assay reflects different oxidising properties of PM_2.5, including particle-bound reactive oxygen species (DCFH), superoxide radical production (EPR) and catalytic redox chem. (DTT/AA), and a combination of these four assays provided a detailed overall picture of the oxidising properties of PM_2.5 at a central site in Beijing. Pos. correlations of OP (normalized per volume of air) of all four assays with overall PM_2.5 mass were observed, with stronger correlations in winter compared to summer. In contrast, when OP assay values were normalized for particle mass, days with higher PM_2.5 mass concentrations (μgm-3) were found to have lower mass-normalized OP values as measured by AA and DTT. This finding supports that total PM_2.5 mass concentrations alone may not always be the best indicator for particle toxicity. Univariate anal. of OP values and an extensive range of addnl. measurements, 107 in total, including PM_2.5 composition, gas-phase composition and meteorol. data, provided detailed insight into the chem. components and atm. processes that determine PM_2.5 OP variability. Multivariate statistical analyses highlighted associations of OP assay responses with varying chem. components in PM_2.5 for both mass- and volume-normalized data. AA and DTT assays were well predicted by a small set of measurements in multiple linear regression (MLR) models and indicated fossil fuel combustion, vehicle emissions and biogenic secondary organic aerosol (SOA) as influential particle sources in the assay response. Mass MLR models of OP associated with compositional source profiles predicted OP almost as well as volume MLR models, illustrating the influence of mass composition on both particle-level OP and total volume OP. Univariate and multivariate anal. showed that different assays cover different chem. spaces, and through comparison of mass- and volume-normalized data we demonstrate that mass-normalized OP provides a more nuanced picture of compositional drivers and sources of OP compared to volume-normalized anal. This study constitutes one of the most extensive and comprehensive composition datasets currently available and provides a unique opportunity to explore chem. variations in PM_2.5 and how they affect both PM_2.5 OP and the concentrations of particlebound reactive oxygen species. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Photobase generating monomers: synthesis, evaluation and utilization for fabricating fluorescence patterns was written by Liu, Lanlan;Guo, Jinbao;Li, Zihao;Wei, Jie. And the article was included in RSC Advances in 2014.COA of Formula: C17H10O4 This article mentions the following:

In this study, we fabricated four new photobase generating monomers, in which carbamate units functioned as the photobase generating moieties, methacrylate units served as the polymerizable groups and four different groups, succinimido, camphorquinone 3-oximino, di-2-thienyl ketoximino and difuril dioximino units, acted as photosensitive species. The effect of different photosensitive species on the photochem. behavior of the monomers was investigated in detail. The results demonstrate that, among the four monomers, succinimido methacryloxyethyl carbamate (SMC) exhibits the most stable photobase generating property. Furthermore, a copolymer containing SMC is used for a fluorescence imaging material. The fluorescence spectrum of the fluorescamine-treated irradiated copolymer film showed a strong fluorescence in the range of 420-650 nm with a fluorescence maximum at 476 nm. The patterns in the copolymer films exhibit very distinct fluorescence images with colors of blue, green and red at certain observation wavelengths. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents was written by Pieroni, Marco;Azzali, Elisa;Basilico, Nicoletta;Parapini, Silvia;Zolkiewski, Michal;Beato, Claudia;Annunziato, Giannamaria;Bruno, Agostino;Vacondio, Federica;Costantino, Gabriele. And the article was included in Journal of Medicinal Chemistry in 2017.Recommanded Product: 1646-27-1 This article mentions the following:

Malaria eradication is a global health priority, but current therapies are not always suitable for providing a radical cure. Artemisinin has paved the way for the current malaria treatment, the so-called Artemisinin-based Combination Therapy (ACT). However, with the detection of resistance to ACT, innovative compounds active against multiple parasite species and at multiple life stages are needed. GlaxoSmithKline has recently disclosed the results of a phenotypic screening of an internal library, publishing a collection of 400 antimalarial chemotypes, termed the “Malaria Box”. After anal. of the data set, we have carried out a medicinal chem. campaign in order to define the structure-activity relationships for one of the released compounds, which embodies a benzothiophene-2-carboxamide core. Thirty-five compounds were prepared, and a description of the structural features responsible for the in vitro activity against different strains of P. falciparum, the toxicity, and the metabolic stability is herein reported. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorescence lifetime predicts performance of voltage sensitive fluorophores in cardiomyocytes and neurons was written by Boggess, Steven C.;Lazzari-Dean, Julia R.;Raliski, Benjamin K.;Mun, Dong Min;Li, Amy Y.;Turnbull, Joshua L.;Miller, Evan W.. And the article was included in RSC Chemical Biology in 2021.Computed Properties of C20H10Cl2O5 This article mentions the following:

Voltage imaging with fluorescent indicators offers a powerful complement to traditional electrode or Ca²⁺-imaging approaches for monitoring elec. activity. Small mol. fluorescent indicators present the unique opportunity for exquisite control over mol. structure, enabling detailed investigations of structure/function relationships. In this paper, we tune the conjugation between aniline donors and aromatic π systems within the context of photoinduced electron transfer (PeT) based voltage indicators. We describe the design and synthesis of four new voltage-sensitive fluorophores (VoltageFluors, or VFs). Three of these dyes have higher relative voltage sensitivities (ΔF/F) than the previously-reported indicator, VF2.1.Cl. We pair these new indicators with existing VFs to construct a library of voltage indicators with varying degrees of conjugation between the aniline nitrogen lone pair and the aromatic π system. Using a combination of steady-state and time-resolved fluorescence spectroscopy, cellular electrophysiol., fluorescence lifetime imaging microscopy (FLIM), and functional imaging in mammalian neurons and human cardiomyocytes, we establish a detailed link between the photophys. properties of VF dyes and their ability to report on membrane potential dynamics with high signal-to-noise. Anilines with intermediate degrees of conjugation to the aromaticπ system experience intermediate rates of PeT and possess the highest absolute voltage sensitivities. Measured using FLIM in patch-clamped HEK cells, we find that the absolute voltage sensitivity of fluorescence lifetime (Δτ_fl per mV), coupled with traditional fluorescence intensity-based metrics like ΔF/F and signal-to-noise ratio (SNR), provides a powerful method to both predict and understand indicator performance in cellular systems. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Investigation of the interactions between flavonoids and human organic anion transporting polypeptide 1B1 using fluorescent substrate and 3D-QSAR analysis was written by Xiang, Yiqun;Liu, Shuai;Yang, Jingjie;Wang, Zhongmin;Zhang, Hongjian;Gui, Chunshan. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 2020.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. Flavonoids are widely distributed in food and beverages and thus our bodies are frequently exposed to them. Therefore, investigation of the interactions between OATP1B1 and flavonoids could be of great significance. In the present study, 25 common flavonoids were investigated for their interactions with OATP1B1 using the fluorescent substrate 2′,7′-dichlorofluorescein (DCF) and three-dimensional quant. structure-activity relationship (3D-QSAR) anal. Kinetic study showed that OATP1B1-mediated DCF uptake exhibited a monophasic saturation kinetics with a K_m value of 9.7 ± 2.4 μM. Inhibition assay for flavonoids on OATP1B1-mediated DCF uptake was performed and their IC₅₀ values were determined upon which reliable and predictive CoMFA (q² = 0.604, r² = 0.841) and CoMSIA (q² = 0.534, r² = 0.807) models were developed. Our exptl. and computational results showed that flavonoid aglycons interacted with OATP1B1 much stronger than their glycosides such as 3-O- and 7-O-glycosides as bulky hydrophilic and hydrogen-bond forming substituents at C-3 and C-7 positions on rings A and C were unfavorable for their binding. On the other hand, the presence of hydrogen-bond forming groups on ring B was beneficial as long as the number of hydroxyl groups was not >2. Our results also indicated that flavones usually interacted with OATP1B1 much stronger than their 3-hydroxyflavone counterparts (flavonols). The obtained information and 3D-QSAR models could be useful for elucidating and predicting the interactions between flavonoids and human OATP1B1. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Simultaneous determination of 16 sulfonamide residues in beef by high performance liquid chromatography-fluorescence detection with online post-column derivatization was written by Xu, Xu;Xiao, Yuancan;Geng, Dandan;Pi, Li;Dong, Qi;Hu, Fengzu. And the article was included in Sepu in 2016.Category: benzofurans This article mentions the following:

In this study, we investigated the effects of the four kinds of derivatization reagents, including fluorescamine, o-phthaladehyde, fluorescein isothiocyanate isomer and 2,3-naphthalenedicarboxaldehyde. A high performance liquid chromatog. with fluorescence detection method for the rapid determination of 16 sulfonamide residues in beef was developed by using improved QuEChERS method for sample pretreatment and fluorescamine for online post-column derivatization. The beef samples were extracted with acetonitrile containing 1% (volume/volume) acetic acid, cleaned-up by QuEChERS method, injected for online post-column derivatization with fluorescamine, and then analyzed with fluorescence detection. Under the optimized conditions of QuEChERS and chromatog., the 16 sulfonamide residues showed good linearities in the range of 0.024-2.533 mg/L with the correlation coefficients (γ) higher than 0.992. The limits of detection of the method were 1.6 to 8.2 μg/kg. The average recoveries of the 16 sulfonamide residues were in the range of 66.6%-109.5% with the relative standard deviations from 0.9% to 9.9%. The method has the advantages of rapidity, simplicity, high sensitivity and better purification effect. It is suitable for the rapid determination of the sulfonamide residues in beef. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Category: benzofurans).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dual-Channel Theranostic System for Quantitative Self-Indication and Low-Temperature Synergistic Therapy of Cancer was written by Wang, Cheng;Chen, Shaoqing;Yu, Fangying;Lv, Jianghong;Zhao, Rui;Hu, Fuqiang;Yuan, Hong. And the article was included in Small in 2021.Synthetic Route of C20H10Cl2O5 This article mentions the following:

A conventional theranostic system usually employs a single fluorescence channel to show the pharmacokinetic events, which usually fails to quant. reveal the true cumulative drug release and with low accuracy. Herein, indocyanine green (ICG) and chlorins e6 (Ce6) are selected not only as conventional photothermal/photodynamic agents, but also to offer two independent fluorescence channels to cross validate the authenticity of pharmacokinetic events and to quant. reveal cumulative drug release in tumor tissues in a “turn on” manner. Employing the Ca2+ of amorphous calcium carbonate as a reversible linker, the photosensitivity and fluorescence of Ce6 are phys. quenched by ICG during circulation to reduce the side effect of photodynamic therapy (PDT) while being readily restored in tumor tissue to reveal the quant. drug release. Most importantly, the combination of photothermal therapy (PTT) and PDT allows low-temperature synergistic therapy of cancer through the controlled expression of heat shock protein in cells and mild hyperthermia enhanced reactive oxygen species diffusion/penetration among cells. This work not only develops a facile approach to fabricate a dual-channel theranostic system to precisely indicate the accumulation and quant. drug release in tumor tissue, but also presents a unique low-temperature synergistic strategy to destroy tumor in an effective and minimally invasive manner. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Synthetic Route of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dietary supplementation with curcumin-loaded nanocapsules in lambs: Nanotechnology as a new tool for nutrition was written by Marcon, Hiam;Griss, Luiz G.;Molosse, Vitor L.;Cecere, Bruno G. O.;Alba, Davi F.;Leal, Karoline W.;Galli, Gabriela M.;Souza, Carine F.;Baldissera, Matheus D.;Gundel, Samanta;de A. Bassotto, Vitoria;Ourique, Aline F.;Vedovatto, Marcelo;Da Silva, Aleksandro S.. And the article was included in Animal Nutrition in 2021.Category: benzofurans This article mentions the following:

Curcumin-containing nanocapsule powder formulations have not been used in ruminant feed to date, despite the fact that curcumin is known to be a functional food additive. The objective of this study was to determine whether Et polymethacrylate (Eudragit L-100) nanocapsules loaded with curcumin (N-CU) would improve health and growth of lambs. Thirty-two male Lacaune lambs (body weight [BW] = 16 ± 0.99 kg; 45 d of age) were randomly assigned to 1 of 4 treatments: T0, T1, T2 and T4, representing supplementation of curcumin at 0, 1, 2, and 4 mg/kg concentrate, resp. The animals in each treatment were allocated in 4 pens of 2 lambs each (8 lambs per treatment). The experiment lasted 17 d, with samples and measurements collected on d 0, 7, 12, and 17. The T2 lambs had greater average daily gain than T0 lambs. Regression anal. showed that the ideal dose of N-CU to enhance weight gain was 1.89 mg/kg concentrate There were significant interactions (P < 0.05) between treatments x time for hematol. variables, particularly for increases in erythrocytes (T2) and reductions in counts of leukocytes, neutrophils, and lymphocytes in T1 and T2. There were significant interactions between treatment x time for total protein, globulin, urea, and triglyceride levels. Stimulation of the antioxidant system was also observed There were increased levels of non-protein thiols (NPSH), as well as increased activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) in the supplemented animals. Levels of reactive oxygen species (ROS) were lower in the serum of supplemented lambs. In general, the 4 mg/kg dose had no pos. effects on growth or health. This was an unexpected result, given the known properties of curcumin. Taken together, these findings suggest that addition of low concentrations of nanoencapsulated curcumin (T1 and T2) in lamb feed improves health, minimizing oxidative stress and generates anti-inflammatory effects that may have contributed indirectly to greater weight gain. Nanocapsules potentiate the effects of curcumin and may emerge as a new tool in animal nutrition. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Category: benzofurans).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem