Day: February 24, 2023

NMR-based metabolomic approach to understanding Zeng-Sheng-Ping-induced hepatotoxicity, and identifying possible toxic constituents by LC-MS profiles was written by Wu, Yan;Wang, Jia-Qi;Wang, Ya-Nan;Pang, Xiao-Xia;Bao, Jie;Guan, Xiao-Bing;Wang, Su-Juan. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2022.Recommanded Product: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

Zeng-Sheng-Ping (ZSP) tablets, made from six Chinese herbs, are widely used in the chemoprevention and treatment of precancerous lesions in patients with gastrointestinal cancer. However, sporadic cases of liver injury have occurred. Herein, the serum metabolites in hamsters with ZSP-induced liver damage were analyzed by NMR-based metabolomics. Twelve metabolites associated with ZSP-induced hepatoxicity were identified. Amino acid metabolism and the urea cycle were significantly altered, and three associated amino acid metabolic enzymes (PAH, GS, and GLS) were further validated by ELISA. Therefore, 12 metabolites and 3 amino acid metabolic enzymes were proposed as potential biomarkers in ZSP-induced liver injury. The chem. constituents of ZSP tablets were profiled using liquid chromatog.-mass spectrometry. The furanoids in two herbs, Dioscorea bulbifera L. and Dictamnus dasycarpus Turcz., were proposed to be the major hepatotoxic constituents in ZSP, leading to an improved preparation method with low hepatotoxicity for ZSP. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Recommanded Product: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HEPES is not suitable for fluorescence detection of HClO: a novel probe for HClO in absolute PBS was written by Xing, Panfei;Gao, Kuo;Wang, Beng;Gao, Jian;Yan, Hui;Wen, Jia;Li, Weisi;Xu, Yongqian;Li, Hongjuan;Chen, Jianxin;Wang, Wei;Sun, Shiguo. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 3326-34-9 This article mentions the following:

HEPES is not suitable for fluorescence detection of HClO because it can be oxidized by HClO. A novel probe for HClO, which can selectively and sensitively detect HClO in absolute PBS, was developed on the basis of an oxidation reaction with an azo moiety. Furthermore, it works well in live mouse imaging. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Related Products of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Simultaneous Sensitive MEKC-LIF Determination of Homocysteine, Homoarginine, and Six Arginine Metabolic Derivatives in Fluids from Type 2 Diabetics with Peptic Ulcer Bleeding was written by Liang, Qianping;Chen, Hongchao;Li, Fuqing;Du, Xiaolin. And the article was included in Chromatographia in 2015.Computed Properties of C25H15NO9 This article mentions the following:

The suitability of micellar electrokinetic capillary chromatog. (MEKC) with laser-induced fluorescence (LIF) detection for simultaneous determination of two arginine analogs (homocysteine and homoarginine) and five closely related metabolites (asym. dimethyl-L-arginine, dimethyl-L-arginine, monomethyl-L-arginine, citrulline, and ornithine) in fluids from type 2 diabetics with peptic ulcer bleeding (PUB) has been studied. 5-Carboxyfluorescein succinimidyl ester (CFSE) was chosen as the fluorescent labeling reagent and non-endogenous phenylpropanolamine (PPA) as the internal standard Conditions affecting derivatization and separation were optimized. Under the optimum conditions, maximum derivatization could be achieved in 20 min at room temperature Complete baseline separation was achieved in 10 min, and the relative standard deviations (relative standard deviation) of migration times and corrected peak areas were <3% for intra-day assay and <5% for inter-day assay. Limits of detection (LODs) were 0.12-1.70 nM for the eight analytes, which are well below the concentrations expected in real fluids. Compared with previously reported methods, 5 to 600-fold improvements in sensitivity were achieved using LIF detection. Sample preparation and anal. time were short and the derivatives of the analytes were highly stable. The method was fully validated with real plasma and urine and recoveries of spiked compounds were 95-102% with the relative standard deviation <4%. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Computed Properties of C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Computed Properties of C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparative purification of total flavonoids from Sophora tonkinensis gagnep. by macroporous resin column chromatography and comparative analysis of flavonoid profiles by HPLC-PAD was written by Hou, Mengyang;Hu, Wenzhong;Xiu, Zhilong;Jiang, Aili;Men, Lei;Hao, Kexin;Sun, Xingsheng;Cao, Duo. And the article was included in Molecules in 2019.Computed Properties of C22H22O10 This article mentions the following:

For the full development and utilization of Sophora tonkinensis Gagnep., this study was primarily intended to established a simple and efficient approach for the preparative purification of total flavonoids from S. tonkinensis by macroporous resin column chromatog. (MRCC). The adsorption and desorption characteristics of the total flavonoids on ten macroporous resins were first studied, and AB-8 resin was chosen as the most suitable, and the adsorption data were best fitted to the pseudo-second-order kinetics model and Langmuir isotherm model. Furthermore, the technol. parameters for the purification of the total flavonoids were optimized using column chromatog. After a sample one-step purification procedure, the content of the total flavonoids increased by about 4.76-fold from 12.14% to 57.82%, with a recovery yield of 84.93%. In addition, the comparative anal. of the flavonoid extracts before and after purification was performed by high-performance liquid chromatog. coupled with photodiode-array detection (HPLC-PAD). The results showed that the contents of six major flavonoids in the purified product were all higher than before the purification Therefore, the AB-8 MRCC established in this work was a promising method for the industrial-scale purification of the total flavonoids from S. tonkinensis. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Computed Properties of C22H22O10).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Computed Properties of C22H22O10

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid hydrolysis and electrochemical detection of trace carbofuran at a disposable heated screen-printed carbon electrode was written by Wei, Hang;Sun, Jian-Jun;Wang, Yan-Min;Li, Xiao;Chen, Guo-Nan. And the article was included in Analyst (Cambridge, United Kingdom) in 2008.Synthetic Route of C10H12O2 This article mentions the following:

A disposable heated screen-printed carbon electrode (HSPCE) is fabricated. It demonstrates rapid responses to elec. heating and is easily elevated above the water b.p. by a high frequency a.c. The temperature rise at the HSPCE was strongly dependent on the square of the heating current and the electrode width. Carbofuran (CAF) could be rapidly hydrolyzed to carbofuran phenol at the HSPCE with raised temperature, and then determined at the same electrode at room temperature by differential potential voltammetry (DPV). The factors influencing the detection were examined, including pH, hydrolytic temperature and heating time. Under the optimum conditions, the detection linear range of CAF was from 4.0 × 10^-7 to 4.0 × 10^-4 mol L^-1 and the detection limit was 5.0 × 10^-8 mol L^-1 (S/N = 3). This method was successfully applied to the determination of CAF residues in real samples (spiked water, soil and vegetables), and satisfactory recoveries were obtained. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Synthetic Route of C10H12O2).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C10H12O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chronic constipation diagnosis and treatment evaluation: the “CHRO.CO.DI.T.E.” study was written by Bellini, Massimo;Usai-Satta, Paolo;Bove, Antonio;Bocchini, Renato;Galeazzi, Francesca;Battaglia, Edda;Alduini, Pietro;Buscarini, Elisabetta;Bassotti, Gabrio. And the article was included in BMC Gastroenterology in 2017.Computed Properties of C18H26ClN3O3 This article mentions the following:

Background: According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipation, NRC). The aim of the study was is to evaluate the various clin. presentation and management of FC, IBS-C and NRC in Italy. Methods: During a 2-mo period, 52 Italian gastroenterologists recorded clin. data of FC, IBS-C and NRC patients, using Bristol scale, PAC-SYM and PAC-QoL questionnaires. In addition, gastroenterologists were also asked to record whether the patients were clin. assessed for CC for the first time or were in follow up. Diagnostic tests and prescribed therapies were also recorded. Results: Eight hundred seventy-eight consecutive CC patients (706 F) were enrolled (FC 62.5%, IBS-C 31.3%, NRC 6. 2%). PAC-SYM and PAC-QoL scores were higher in IBS-C than in FC and NRC. 49.5% were at their first gastroenterol. evaluation for CC. In 48.5% CC duration was longer than 10 years. A specialist consultation was requested in 31.6%, more frequently in IBS-C than in NRC. Digital rectal examination was performed in only 56.4%. Diagnostic tests were prescribed to 80.0%. Faecal calprotectin, thyroid tests, celiac serol., breath tests were more frequently suggested in IBS-C and anorectal manometry in FC. More than 90% had at least one treatment suggested on chronic constipation, most frequently dietary changes, macrogol and fibers. Antispasmodics and psychotherapy were more frequently prescribed in IBS-C, prucalopride and pelvic floor rehabilitation in FC. Conclusions: Patients with IBS-C reported more severe symptoms and worse quality of life than FC and NRC. Digital rectal examination was often not performed but at least one diagnostic test was prescribed to most patients. Colonoscopy and blood tests were the “first line” diagnostic tools. Macrogol was the most prescribed laxative, and prucalopride and pelvic floor rehabilitation represented a “second line” approach. Diagnostic tests and prescribed therapies increased by increasing CC severity. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8Computed Properties of C18H26ClN3O3).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Computed Properties of C18H26ClN3O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Burn Intensity Drives the Alteration of Phenolic Lignin to (Poly) Aromatic Hydrocarbons as Revealed by Pyrolysis Gas Chromatography-Mass Spectrometry (Py-GC/MS) was written by Chen, Huan;Wang, Jun-Jian;Ku, Pei-Jia;Tsui, Martin Tsz-Ki;Abney, Rebecca B.;Berhe, Asmeret Asefaw;Zhang, Qiang;Burton, Sarah D.;Dahlgren, Randy A.;Chow, Alex T.. And the article was included in Environmental Science & Technology in 2022.Recommanded Product: 2,3-Dihydrobenzo[b]furan This article mentions the following:

High-intensity wildfires alter the chem. composition of organic matter, which is expected to be distinctly different from low-intensity prescribed fires. Herein, we used pyrolysis gas chromatog./mass spectrometry (Py-GC/MS), in conjunction with solid-state ¹³C NMR and Fourier transform IR (FT-IR) spectroscopy, to assess chem. alterations from three wildfires and a long-term frequent prescribed fire site. Our results showed that black ash formed under moderate intensity burns contained less aromatic (ArH), polyaromatic hydrocarbon (PAH), and nitrogen-containing compounds (Ntg) but more lignin (LgC) and phenol compounds (PhC), compared to white ash formed under high intensity burns. Both ¹³C NMR and FT-IR confirmed a higher relative percentage of carboxyl carbon in white ash, indicating the potential for higher water solubility and more mobile carbon, relative to black ash. Compared to wildfires, ash from low-intensity prescribed fire contained less ArH, PAH, and Ntg and more LgC and PhC. Controlled laboratory burning trials indicated that organic matter alteration was sensitive to the burn temperature, but not related to the fuel type (pine vs. fir) nor oxygen absence/presence at high burn temperatures This study concludes that higher burn temperatures resulted in higher (poly)aromatic carbon/nitrogen and lower lignin/phenol compounds In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Recommanded Product: 2,3-Dihydrobenzo[b]furan).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 2,3-Dihydrobenzo[b]furan

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC method for simultaneous determination of trifolirhizin and maackiain in Sophora tonkinensis Gagnep. Var. polyphylla S. Z. Huang et Z. C. Zhou was written by Liu, Ji-cheng;Lu, Sen-hua;Xie, Wei;Lu, Wen-jie. And the article was included in Yaowu Fenxi Zazhi in 2015.Recommanded Product: 6807-83-6 This article mentions the following:

Objective: To establish an HPLC method to determine the content of two flavonoids (trifolirhizin and maackiain) in Sophora tonkinensis Gagnep. var. polyphylla S. Z. Huang et Z. C. Zhou. Methods: An Agilent Eclipse XDB-C₁₈ column (4.6 mm × 250 mm, 5 μm) was adopted, and the mobile phase consisted of acetonitrile and 0.1% aqueous acetic acid with a gradient elution. The flow rate was 1.0 mL·min^-1, the column temperature was 25°C, the detection wavelength was 310 nm and the injection volume was 10 μL, the sample was quantified with external standard Results: The calibration curve of trifolirhizin was in good linearity at 0.0251-2.51 μg (r = 0.9990) and the average recovery was 97.0% with RSD of 1.5%. The calibration curve of maackiain was in good linearity at 0.0252-2.52 μg (r = 0.9990) and the average recovery was 101.3% with RSD of 2.2%. Conclusion: The method established in this paper conforms to the requirements of the methodol. validation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Recommanded Product: 6807-83-6).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 6807-83-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Characteristics and synergistic effects of co-pyrolysis of microalgae with polypropylene was written by Jiang, Liyang;Zhou, Zhen;Xiang, Huan;Yang, Yang;Tian, Hong;Wang, Jiawei. And the article was included in Fuel in 2022.Product Details of 496-16-2 This article mentions the following:

To further improve the quality of microalgae-derived bio-oil, the characteristics, kinetic parameters and product distribution of the co-pyrolysis of polypropylene (PP) and Chlorella vulgaris (C.V) were studied by thermogravimetric anal. (TGA) and pyrolysis gas chromatog./mass spectrometry (Py-GC/MS). The TGA results showed that with the increase of the PP amount, the peak temperature of maximum pyrolysis weight loss of C. V decreased, but the trend of PP was opposite. Compared with the exptl. and theor. values, it was found that the residual amount of solid coke and the total activation energy required for co-pyrolysis were significantly reduced, which indicated that there was an obvious synergistic effect during the co-pyrolysis process. The Py-GC/MS results showed that when the PP mass ratio was 0.75 and the final pyrolysis temperature was 500°C, the reaction activation energy and hydrocarbon yield had the best synergistic effect. Moreover, the co-pyrolysis of C. V and PP promoted the formation of aliphatic hydrocarbons, inhibited the aromatisation and Maillard reactions, and hindered the formation of aromatics, nitrogenous compounds, acids and oxides. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Product Details of 496-16-2).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 496-16-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Supplemental studies on the relationship between structure and spectrum of fluorescein was written by Chen, Sheng-Chih;Nakamura, Hiroshi;Tamura, Zenzo. And the article was included in Chemical & Pharmaceutical Bulletin in 1979.Synthetic Route of C22H16O5 This article mentions the following:

The relationship between the structure and spectrum of fluorescein I in aqueous solution was investigated by comparing the absorption and fluorescence properties of I with those of monomethylfluorescein, dimethylfluorescein, and fluorescein Me ester (II). Fluorescein was predominantly present in its univalent cation, neutral lactonoid (III), univalent anion and bivalent anion (IV) forms at pH < 1, pH 3, pH 5-6 and pH > 8, resp. All form except III were fluorescent and IV fluoresced most intensely. The neutral quinonoid form was not detected in aqueous solution, contrary to results of previous authors. In the experiment, the researchers used many compounds, for example, 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7Synthetic Route of C22H16O5).

3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C22H16O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem