Day: February 23, 2023

Study of erythrosine B-mediated photodynamic to effectively inactivate enveloped RNA viruses by destroying viral nucleic acid was written by Ding, Xiaoyan;Yang, Maocheng;Guo, Hongxia;Chao, Xiaojuan;Li, Jintao. And the article was included in Huanan Guofang Yixue Zazhi in 2022.Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) This article mentions the following:

Objective To study the disinfective efficacy of erythrosine B-mediated photodynamic against enveloped RNA viruses and evaluate the feasibility of disinfective scheme in destroying viral nucleic acid. Methods Dengue virus 4 (DENV 4) and Sindbis virus (SINV) were used as indicative virus, which were added with 2 μg/mL erythrosine B and illuminated at 535 nm for 10 min. The disinfective effect was evaluated by observing cytopathic disease and real-time quant. reverse transcription polymerase chain reaction (RT-PCR). Results Erythrosine B-mediated photodynamic could effectively prevent the infection and replication of DENV 4 and SINV by destroying the viral nucleic acid of the virus. Conclusion Erythrosine B, as a good photosensitizer mediated photodynamic, can effectively inactivate enveloped RNA viruses, and can be used as a new way to inactivate viruses in vitro. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dietary intake of artificial food color additives containing food products by school-going children was written by Asif Ahmed, Mohammed;Al-Khalifa, Abdulrahman S.;Al-Nouri, Doha M.;El-din, Mohamed Fekry Serag. And the article was included in Saudi Journal of Biological Sciences in 2021.Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) This article mentions the following:

Nutritional risk in children is associated with food safety. This is the first study to identify the food type consumed by 6-17-yr-old school-going children in Saudi Arabia. Eight permitted artificial food color additives, including Tartrazine (E102), Sunset Yellow (E110), Carmoisine (E122), Allura Red (E129), Indigo Carmine (E132), Brilliant Blue (E133), Fast Green (E143), and Black PN (E151), and two non-permitted ones, Erythrosine (E127) and Red 2G (E128), were determined using 24-h dietary recall questionnaires. Artificial color additives in 839 food products were divided into nine categories, including biscuits, cakes, chocolates, chips, ice cream, juices and drinks, candy, jelly, and chewing gum, are determined using high performance liquid chromatog. and diode array detector. The results indicated a high intake of juices and drinks, ice cream, and cakes, but low consumption of chewing gum among school-going children. Among the permitted artificial food color additives, Brilliant Blue (E133) (54.1%) and Tartrazine (E102) (42.3%) were the most commonly used. Sunset Yellow (E110) in one chocolate sample, Tartrazine (E102) and Sunset Yellow (E110) in one and two juice and drink samples, resp., and Brilliant Blue (E133) in two candy samples exceeded the permitted level. Therefore, further investigations are needed to provide insights into the possible adverse health effects of high intake of these additives in artificial food coloring on the test population are warranted. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Visible-Light Photoredox-Catalyzed Carboxylation of Activated C(sp³)-O Bonds with CO₂ was written by Ran, Chuan-Kun;Niu, Ya-Nan;Song, Lei;Wei, Ming-Kai;Cao, Yi-Fei;Luo, Shu-Ping;Yu, Yu-Ming;Liao, Li-Li;Yu, Da-Gang. And the article was included in ACS Catalysis in 2022.Category: benzofurans This article mentions the following:

A visible-light photoredox-catalyzed carboxylation of activated C(sp₃)-O bonds with CO₂ under mild and transition-metal-free conditions was reported. A variety of benzyl alcs. and derivatives, RCH(R¹)OR² (R = 4-phenylphenyl, 6-methoxynaphthalen-2-yl, 1-benzofuran-2-yl, etc.; R¹ = H, Me, cyclohexyl, propan-2-yl, etc.; R² = H, Piv, Ac) bearing primary, secondary, and more challenging tertiary C(sp₃)-O bonds, undergo carboxylation with CO₂, generating valuable aryl acetic acids RCH(R¹)COOH, such as ibuprofen, naproxen, fenoprofen, and flurbiprofen, with broad substrate scope and good functional group tolerance. Moreover, this strategy is also applicable to other carboxylates of α-hydroxyl amides, esters, and nitriles, as well as allyl alcs., representing a practical method for aliphatic carboxylic acid synthesis. In the experiment, the researchers used many compounds, for example, 2-Benzofuranacetic acid (cas: 62119-70-4Category: benzofurans).

2-Benzofuranacetic acid (cas: 62119-70-4) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hydrothermal Liquefaction of Loblolly Pine: Effects of Various Wastes on Produced Biocrude was written by Saba, Akbar;Lopez, Brandon;Lynam, Joan G.;Reza, M. Toufiq. And the article was included in ACS Omega in 2018.Product Details of 1563-38-8 This article mentions the following:

In this study, feedstock interaction of cow manure and digested sewage sludge on hydrothermal liquefaction (HTL) of loblolly pine (LP) was evaluated. Noncatalytic HTL experiments were performed at reaction temperatures of 250, 275, and 300 °C at a constant reaction time of 30 min. Cyclohexane and acetone were used for biocrude extraction sep. The study focuses on the characteristics of the produced biocrude, and thus, physicochem. properties of biocrudes were examined by gas chromatog.-mass spectrometry, Fourier-transform IR spectroscopy, d., and viscosity measurements, in addition to comparing mass and energy yields. On a LP basis, the biocrude yield reached as high as 30 and 17% for acetone and cyclohexane extraction, resp., at the highest reaction temperature Elemental carbon and energy contents increased with increasing HTL temperature for all cases. Alkalinity of the HTL process liquid (aqueous phase) increases from the HTL of sludge, and thus, it favored the formation of nonpolar compounds in biocrude. On the other hand, acidity of the reaction medium increases with the HTL of manure and pine, and thus, phenolic compounds in biocrude were increasing. Cyclohexane was more effective for sludge/LP biocrude extraction, whereas acetone was effective for manure/LP. D. of cyclohexane extracted sludge/LP biocrudes at 300 °C was less than 1000 kg m^-3, whereas acetone-extracted biocrudes had densities greater than 1000 kg m^-3. For all the biocrudes, viscosity was reduced considerably for the mixtures when compared to biocrudes from LP alone. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Product Details of 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Product Details of 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT_1A and Serotonin Transporter Affinity within a Class of N-Aryloxyethylindolylalkylamines was written by Mewshaw, Richard E.;Zhou, Dahui;Zhou, Ping;Shi, Xiaojie;Hornby, Geoffrey;Spangler, Taylor;Scerni, Rosemary;Smith, Deborah;Schechter, Lee E.;Andree, Terrance H.. And the article was included in Journal of Medicinal Chemistry in 2004.SDS of cas: 4790-79-8 This article mentions the following:

N-Aryloxylethylindolealkylamines (5) having dual 5-HT transporter and 5-HT_1A affinity are described. These compounds represent truncated analogs of our previously reported piperidinyl derivatives (3). Compounds in this investigation were found to have more similar affinities and functional activities for the 5-HT_1A receptor and 5-HT transporter. Though 5-HT_1A antagonism is not consistently observed throughout series 5, several mol. features were found to be essential to obtain high and balanced activities. The proper placement of a heteroatom in the aryl ring and the length of the linkage used to tether the indole moiety had significant influence on 5-HT_1A and 5-HT transporter affinities. Introduction of a halogen into the aryl ring usually lowered intrinsic activity and in some cases led to full 5-HT_1A antagonists. Compounds 33 and 34 were observed to be full 5-HT_1A antagonists with K_i values of approx. 30 nM for the 5-HT_1A receptor and K_i values of 5 and 0.5 nM for the 5-HT transporter, resp. Unfortunately, similar to our previous series (3), compounds in this report also had high affinity for the α₁ receptor. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8SDS of cas: 4790-79-8).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 4790-79-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Analysis for intermediate and by-product of crystal violet lactone with IR and NMR was written by Qi, Zhengjian;Xu, Jiang. And the article was included in Dongnan Daxue Xuebao, Ziran Kexueban in 2004.Application In Synthesis of Crystal violet lactone This article mentions the following:

The anal. of tri(p-dimethylaminophenyl)benzoic acid and trip-dimethylaminophenyl) methane with IR and NMR is described. They are intermediate and byproduct of crystal violet lactone (CVL) while it was synthesized. The main groups of both intermediate and byproduct were indicated by IR, and the mol. structures were thoroughly studied according to the chem. shift and coupling constant of ¹H and ¹³C-NMR. Comparing with Sadder standard atlas, it is indicated that the method is scientific and reasonable. The results are useful to the research of synthesis of CVL. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Application In Synthesis of Crystal violet lactone).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of Crystal violet lactone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rational prescription pattern of antibiotics: a quantitative analysis based on Khwaja Yunus Ali Medical College and Hospital (KYAMCH), Sirajganj, Bangladesh was written by Mukul, Emdadul Hasan Md.;Sharif, Imran Md.;Sultana, Afroza Ms;Koly, Farjana Akter;Arfat, Easin Md.;Farnaz, Noor-E-Kashif;Karim, Rezaul Md.;Yeasmin, Farida;Alam, Mehfuz;Ali, Aiub;Khairujjaman, Md.;Abedin, Mohammad Zakerin. And the article was included in Journal of Advances in Medical and Pharmaceutical Sciences in 2021.COA of Formula: C43H51N3O11 This article mentions the following:

Antibiotics, alternatively known as antibacterial drugs, prevent or reduce the development of germs. A decade has been added to the life expectancy of human beings since the discovery of antibiotics. Antibiotic overuse can result in resistance to a wide spectrum of diseases and bacteria. Antibiotic utility is being jeopardized by the rise of resistance. There aren’t enough innovative agents to deal with the problem of resistant strains. The current study targeted to highlight the current status of antibiotic use. The study was designed as a prescription-based survey where the medicines in prescriptions were checked containing antibiotics, whether the drugs were prescribed rationally or not. The study was conducted from Feb. to July 2018 at Khwaja Yunus Ali Medical College and Hospital, Bangladesh. Patient’s data were collected through review of patient medical records and prepared questionnaires. 100 people were interviewed, and their prescriptions were captured as photos and then checked for rationality. The antibiotics are prescribed in the group of 10 to 30 years, 31 to 50 years and more than 50 years of age. The survey demonstrated that 46% of patients know about antibiotics partially, about 74% of patients fulfill their entire course of medication and the rest of the patients stop taking medication after feeling better. Only 21% of patients knew about antibiotic resistance, whereas 37% of patients only heard about antibiotic resistance. According to the age group from low to high, 92.9%, 91.67%, 86.36% prescriptions were rational; 2.4%, 2.78%, 4.55% prescriptions were contraindicated and 4.7%, 5.56%, 9.1% prescriptions where medicines interacted with other non-antibiotic drugs, resp. The overall rational prescription is 91%, whereas 3% of prescriptions are contraindicated and 6% of prescriptions showed interaction between antibiotics and other drugs (non-antibiotics). The study concluded that lack of knowledge and awareness of patients and inaccurate prescription data by physicians are two key factors that contribute to irrational antibiotic usage. In the experiment, the researchers used many compounds, for example, (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4COA of Formula: C43H51N3O11).

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.COA of Formula: C43H51N3O11

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Characterization of Molecular Mass Ranges of Two Coal Tar Distillate Fractions (Creosote and Anthracene Oils) and Aromatic Standards by LD-MS, GC-MS, Probe-MS and Size-exclusion Chromatography was written by Morgan, T. J.;George, A.;Alvarez, P.;Millan, M.;Herod, A. A.;Kandiyoti, R.. And the article was included in Energy & Fuels in 2008.Application of 205-39-0 This article mentions the following:

Laser-desorption mass spectrometry (LD-MS) method development was undertaken to improve estimates of mass ranges for complex hydrocarbon mixtures A creosote oil, an anthracene oil, and a mixture of known polynuclear aromatic hydrocarbon (PAH) compounds were examined The data on the mixture of the four PAHs made it possible to define LD-MS conditions necessary to generate artifacts such as cluster ions by the combination of high laser power and high-mass accelerator voltage. The formation of cluster ions was possible without overloading the detector system. These multimer ions overlapped with higher-mass ion signals from the sample. However, careful balancing of sample concentration, laser power, total ion current, and delayed ion extraction appears to show high-mass materials without generating high-mass multimer (artifact) ions. It is possible to suppress the formation of cluster ions by keeping low target concentrations and, consequently, low gas phase concentrations formed by the laser pulse. The principal method used in this work was the fractionation of samples by planar chromatog. followed by successive LD-MS anal. of the separated fractions directly from the chromatog. plates. This method separated the more abundant small mols. from the less abundant large mols. to permit the generation of their mass spectra independently, as well as reducing the concentration of sample by spreading over the PC-plate. The technique demonstrably suppressed multimer formation and greatly improved the reproducibility of the spectra. Results showed mol. ions in the ranges m/z 1000-2000 for the anthracene oil sample and m/z 600-1500 for the creosote oil sample, tailing off to m/z ∼ 5,000. The creosote oil contained significantly less of this high-mass material than the anthracene oil sample, and in both cases, high-mass material was only present in low quantities. Ion mass range estimates were in close agreement with mol. mass ranges from size exclusion chromatog., and findings were consistent with changes observed in the UV-fluorescence spectra. The method outlined in the paper appears directly applicable to the characterization of heavier coal and petroleum derived fractions. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Application of 205-39-0).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 205-39-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biological activity of Dictamnus dasycarpus against Mythimna separata was written by Yuan, Chun-lan;Wang, Xiao-ling. And the article was included in Baoji Wenli Xueyuan Xuebao, Ziran Kexueban in 2012.Synthetic Route of C14H16O3 This article mentions the following:

This paper is to gain the active compounds from Dictamnus dasycarpus. The solvent partition, preparative TLC, spectral anal. and bioassay are used to gain the active compounds Fraxinellone is a main biol. actives substance from D. dasycarpus. Its antifeeding rate and death rate of 72h at 0.21%(mass percent) against Mythimna separata were 90.4%and 95.2%, resp. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Synthetic Route of C14H16O3).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Synthetic Route of C14H16O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Modulation of the excited state intramolecular electron transfer reaction and dual fluorescence of crystal violet lactone in room temperature ionic liquids was written by Santhosh, Kotni;Samanta, Anunay. And the article was included in Journal of Physical Chemistry B in 2010.HPLC of Formula: 1552-42-7 This article mentions the following:

The influence of polarity, viscosity, and hydrogen bond donating ability of the medium on the fluorescence behavior of crystal violet lactone (CVL), which undergoes excited state electron transfer reaction and exhibits dual fluorescence from two different electronic states, termed as CT_A and CT_B, has been studied in six different room temperature ionic liquids (ILs) using steady state and time-resolved emission techniques. It is shown that the excited state CT_A → CT_B transformation and dual fluorescence of CVL can be controlled by appropriate choice of the ILs. While dual fluorescence of CVL is clearly observed in pyrrolidinium IL, the mol. exhibits a single fluorescence band in ammonium IL. While the second emission from the CT_B state can barely be seen in 1,3-dialkylimidazolium ILs, dual fluorescence is quite prominent in 1-butyl-2,3-dimethylimidazolium IL, [bmMim][Tf₂N]. These contrasting results have been explained taking into account the hydrogen bonding interactions of the 1,3-dialkylimidazolium ions (mediated through the C(2)-hydrogen) with CVL and the viscosity of the ILs. The excited state CT_A → CT_B reaction kinetics has been studied in IL by monitoring the time-evolution of the CT_B emission in [bmMim][Tf₂N]. The solvation dynamics in this IL has been studied by following the dynamic fluorescence Stokes shift of C153, which is used as a probe mol. A comparison of the excited state reaction time and solvation time suggests that the rate of the CT_A → CT_B reaction in moderately viscous ILs is primarily dictated by the rate of solvation. Very little or negligible excitation wavelength dependence of the emission behavior of CVL can be observed in these ILs. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7HPLC of Formula: 1552-42-7).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.HPLC of Formula: 1552-42-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem