Day: February 22, 2023

Reprogramming Urokinase into an Antibody-Recruiting Anticancer Agent was written by Jakobsche, Charles E.;McEnaney, Patrick J.;Zhang, Andrew X.;Spiegel, David A.. And the article was included in ACS Chemical Biology in 2012.HPLC of Formula: 200115-86-2 This article mentions the following:

Synthetic compounds for controlling or creating human immunity have the potential to revolutionize disease treatment. Motivated by challenges in this arena, we report herein a strategy to target metastatic cancer cells for immune-mediated destruction by targeting the urokinase-type plasminogen activator receptor (uPAR). Urokinase-type plasminogen activator (uPA) and uPAR are overexpressed on the surfaces of a wide range of invasive cancer cells and are believed to contribute substantially to the migratory propensities of these cells. The key component of our approach is an antibody-recruiting mol. that targets the urokinase receptor (ARM-U). This bifunctional construct is formed by selectively, covalently attaching an antibody-binding small mol. to the active site of the urokinase enzyme. We demonstrate that ARM-U is capable of directing antibodies to the surfaces of target cancer cells and mediating both antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) against multiple human cancer cell lines. We believe that the reported strategy has the potential to inform novel treatment options for a variety of deadly, invasive cancers. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2HPLC of Formula: 200115-86-2).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.HPLC of Formula: 200115-86-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid separation and simultaneous quantitative determination of 13 constituents in Psoraleae Fructus by a single marker using high-performance liquid chromatography with diode array detection was written by Zhang, Yimin;Chen, Zhiyong;Xu, Xiaokun;Zhou, Qiang;Liu, Xiaolong;Liao, Liping;Zhang, Zijia;Wang, Zhengtao. And the article was included in Journal of Separation Science in 2017.Category: benzofurans This article mentions the following:

Psoraleae Fructus is one of the most popular traditional Chinese medicines. Coumarins, flavonoids, and meroterpenes are the main contributors to the biol. activity of Psoraleae Fructus. In this study, a new method for the quality control of Psoraleae Fructus was developed, through the quant. anal. of multicomponents by single marker with diode array detector. Thirteen components, including psoralenoside, isopsoralenoside, psoralen, isopsoralen, psoralidin, neobavaisoflavone, bavachin, corylin, isobavachalcone, corylifol A, bavachinin, bavachalcone, and bakuchiol were rapidly separated and identified within 12 min by the newly developed method. The feasibility and reliability of this method were corroborated. The method was also compared to the external standard method and detection by corona charged aerosol detector. The results of percent difference (%) and cos (θ) have shown that there were no significant differences observed between the quant. anal. of multicomponents by single marker and external standard method analyses; psoralen and isopsoralen were undetectable with the corona charged aerosol detector due to their but the sensitivity for all the compounds except bakuchiol detected by corona charged aerosol detector are higher than those obtained by diode array detector. In addition, the newly method developed was applied to the quality evaluation of Chinese patent medicines containing Psoraleae Fructus. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Category: benzofurans).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cell Coding Arrays Based on Fluorescent Glycan Nanoparticles for Cell Line Identification and Cell Contamination Evaluation was written by Cheng, Meng;Liu, Lingshan;Zhang, Peipei;Xiong, Shuhan;Dou, Hongjing. And the article was included in ACS Applied Materials & Interfaces in 2021.Recommanded Product: 3326-34-9 This article mentions the following:

Cell lines are applied on a large scale in the field of biomedicine, but they are susceptible to issues such as misidentification and cross-contamination. This situation is becoming worse over time due to the rapid growth of the biomedical field, and thus there is an urgent need for a more effective strategy to address the problem. As described herein, a cell coding method is established based on two types of uniform and stable glycan nanoparticles that are synthesized using the graft-copolymerization-induced self-assembly (GISA) method, which further exhibit distinct fluorescent properties due to elaborate modification with fluorescent labeling mols. The different affinity between each nanoparticle and various cell lines results in clearly distinguishable differences in their endocytosis degrees, thus resulting in distinct characteristic fluorescence intensities. Through flow cytometry measurements, the specific signals of each cell sample can be recorded and turned into a map divided into different regions by statistical processing. Using this sensing array strategy, we have successfully identified six human cell lines, including one normal type and five tumor types. Moreover, cell contamination evaluation of different cell lines with HeLa cells as the contaminant in a semiquant. anal. has also been successfully achieved. Notably, the whole process of nanoparticle fabrication and fluorescent testing is facile and the results are highly reliable. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Recommanded Product: 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Recommanded Product: 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Visible Light-Induced Borylation of C-O, C-N, and C-X Bonds was written by Jin, Shengfei;Dang, Hang. T.;Haug, Graham C.;He, Ru;Nguyen, Viet D.;Nguyen, Vu T.;Arman, Hadi D.;Schanze, Kirk S.;Larionov, Oleg V.. And the article was included in Journal of the American Chemical Society in 2020.COA of Formula: C14H17BO3 This article mentions the following:

Aryl phosphates, arylammonium salts and aryl halides were borylated with B₂pin₂ in photochem. substitution reaction catalyzed by phenothiazines, yielding aryl pinacolboranes and aryltrifluoroborates. Boronic acids are centrally important functional motifs and synthetic precursors. Visible light-induced borylation may provide access to structurally diverse boronates, but a broadly efficient photocatalytic borylation method that can effect borylation of a wide range of substrates, including strong C-O bonds, remains elusive. Herein, we report a general, metal-free visible light-induced photocatalytic borylation platform that enables borylation of electron-rich derivatives of phenols and anilines, chloroarenes, as well as other haloarenes. The reaction exhibits excellent functional group tolerance, as demonstrated by the borylation of a range of structurally complex substrates. Remarkably, the reaction is catalyzed by phenothiazine, a simple organic photocatalyst with MW < 200 that mediates the previously unachievable visible light-induced single electron reduction of phenol derivatives with reduction potentials as neg. as approx. – 3 V vs. SCE by a proton-coupled electron transfer mechanism. Mechanistic studies point to the crucial role of the photocatalyst-base interaction. In the experiment, the researchers used many compounds, for example, 2-(Benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 519054-55-8COA of Formula: C14H17BO3).

2-(Benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 519054-55-8) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.COA of Formula: C14H17BO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance was written by Liu, Ruilong;Li, Wenfeng;Tao, Bangbao;Wang, Xiongjun;Yang, Zhuo;Zhang, Yajuan;Wang, Chenyao;Liu, Rongzhi;Gao, Hong;Liang, Ji;Yang, Weiwei. And the article was included in Nature Communications in 2019.COA of Formula: C23H21N5O3S This article mentions the following:

6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP⁺ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusive. Here we show that upon EGFR activation, 6PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn. This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP⁺ and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis. Abrogating 6PGD Y481 phosphorylation (pY481) dramatically attenuates EGF-promoted glioma cell proliferation, tumor growth and resistance to ionizing radiation. In addition, 6PGD pY481 is associated with Fyn expression, the malignancy and prognosis of human glioblastoma. These findings establish a critical role of Fyn-dependent 6PGD phosphorylation in EGF-promoted tumor growth and radiation resistance. In the experiment, the researchers used many compounds, for example, N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3COA of Formula: C23H21N5O3S).

N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.COA of Formula: C23H21N5O3S

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gadolinium-based contrast agents targeted to amyloid aggregates for the early diagnosis of Alzheimer’s disease by MRI was written by Bort, Guillaume;Catoen, Sarah;Borderies, Helene;Kebsi, Adel;Ballet, Sebastien;Louin, Gaelle;Port, Marc;Ferroud, Clotilde. And the article was included in European Journal of Medicinal Chemistry in 2014.SDS of cas: 200115-86-2 This article mentions the following:

While important efforts were made in the development of positron emission tomog. (PET) tracers for the in vivo mol. diagnosis of Alzheimer’s disease, very few investigations to develop magnetic resonance imaging (MRI) probes were performed. Here, a new generation of Gd(III)-based contrast agents (CAs) is proposed to detect the amyloid β-protein (Aβ) aggregates by MRI, one of the earliest biol. hallmarks of the pathol. A building block strategy was used to synthesize a library of 16 CAs to investigate structure-activity relationships (SARs) on physicochem. properties and binding affinity for the Aβ aggregates. Three types of blocks were used to modulate the CA structures: (i) the Gd(III) chelates (Gd(III)-DOTA and Gd(III)-PCTA), (ii) the biovectors (2-arylbenzothiazole, 2-arylbenzoxazole and stilbene derivatives) and (iii) the linkers (neutrals, positives and negatives with several lengths). These investigations revealed unexpected SARs and a difficulty of these probes to cross the blood-brain barrier (BBB). General insights for the development of Gd(III)-based CAs to detect the Aβ aggregates are described. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2SDS of cas: 200115-86-2).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.SDS of cas: 200115-86-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quinones. XXVI. Condensation of p-quinones with furoylacetic ester, acetylacetone and dibenzoylmethane was written by Grinev, A. N.;Bukhtenko, L. A.;Terent’ev, A. P.. And the article was included in Zhurnal Obshchei Khimii in 1959.SDS of cas: 28241-99-8 This article mentions the following:

To 20.5 g. ZnCl₂ in 45 ml. EtOH was added 27.3 g. furoylacetic ester, followed by 10.8 g. p-benzoquinone (I). After 1 hr. at 100-10° there was isolated 0.6 g. benzodifuran, m. 254-5°, and 4 g. 2-furyl-3-carbethoxy-5-hydroxybenzofuran, m. 155-6° (this treated in dioxane with Me₂SO₄-NaOH gave the 5-methoxy analog, m. 65-5.5°). α-Naphthoquinone in the above condensation gave 2 furyl-3-carbethoxy-5-hydroxynaphthofuran, m. 215-16°; 5-Me ether m. 118-19°. Similarly Ac₂CH₂ and I gave a low yield of 2,6-dimethyl-3,7-diacetylbenzo[1,2-b;4,5-b’]difuran, m. 248-9°, and 60% 2-methyl-3-acetyl-5-hydroxybenzofuran, m. 234°. If I is gradually extracted into the reaction mixture of Ac₂CH₂, ZnCl₂, absolute EtOH and absolute Et₂O, the yield of the last product rises and that of the former product declines to zero. Reaction of Ac₂CH₂ with α-naphthoquinone in the presence of ZnCl₂ as above gave 2-methyl-3-acetyl-5-hydroxynaphthofuran, m. 246-8°. Heating 8 g. 2,3-dichloro-p-benzoquinone with 4.5 g. imine of Ac₂CH₂ in CHCl₃ 45 min. gave 2-methyl-3-acetyl-6,7-dichloro-5-hydroxybenzofuran, 90%, m. 256-7°. Reaction of Bz₂CH₂ with α-naphthoquinone in the presence of ZnCl₂ in EtOH gave 10:1 ratio of II, m. 174-5°, and 2-phenyl-3-benzoyl-5-hydroxynaphthofuran, m. 224-5°. The former treated with aqueous dioxane solution of NaOH gave a blue solution which with Me₂SO₄ gave III, m. 160-60.5°. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8SDS of cas: 28241-99-8).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 28241-99-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A study of 2-aminofurans was written by Lythgoe, David J.;McClenaghan, Ian;Ramsden, Christopher A.. And the article was included in Journal of Heterocyclic Chemistry in 1993.COA of Formula: C8H5NO3 This article mentions the following:

Catalytic reduction of 2-nitrofurans, e.g., I, gives low yields of 2-aminofurans 1 which are not isolated but are trapped using Et ethoxymethylenecyanoacetate (6) or ethoxymethylenemalononitrile (7). In these reactions 2-aminofuran (1a) behaves like a dieneamine with substitution occurring at position 5 of the ring. When the 5-position is substituted reaction takes place at position 3 and thermal cyclization of the product gives furo[2,3-b]pyridine derivatives, e.g., II. An AM1 calculation of the properties of 2-aminofuran (1a) is reported and the results are consistent with observed properties. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5COA of Formula: C8H5NO3).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C8H5NO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors was written by Mahadevan, D.;Cooke, L.;Riley, C.;Swart, R.;Simons, B.;Della Croce, K.;Wisner, L.;Iorio, M.;Shakalya, K.;Garewal, H.;Nagle, R.;Bearss, D.. And the article was included in Oncogene in 2007.Electric Literature of C23H21N5O3S This article mentions the following:

KIT or α-platelet-derived growth factor receptor (α-PDGFR) activating mutations are the pathogenic mechanisms that characterize gastrointestinal stromal tumors (GIST). Despite excellent responses to imatinib mesylate (IM), patients are relapsing. We developed an IM-resistant GIST cell line (GIST-R) from the IM-sensitive GIST882 cell line (GIST-S) by growing these cells in IM. Gene expression profiling (GEP) of GIST-S, GIST-R cells and two IM resistant GIST patients demonstrated that KIT is downregulated implying a major role in IM resistance. Instead, GIST-R cells have acquired IM resistance by overexpressing the oncogenic receptor tyrosine kinase – AXL – in a ‘kinase switch’. Further, the two IM resistant GIST patients express AXL and not c-Kit, seen by immunohistochem. (IHC). Real time reverse transcriptase-polymerase chain reaction and Western blotting of the GIST-S and GIST-R cells confirmed the switch from Kit to AXL. In GIST-R, AXL is tyrosine phosphorylated and its ligand growth-arrest-specific gene 6 is overexpressed implying autocrine activation. The kinase switch is associated with a morphol. change from spindle to epithelioid. Mol. modeling of the kinase domain of mutant c-Kit (V654A) and AXL showed no binding to IM but efficient binding to MP470, a novel c-Kit/AXL kinase inhibitor. MP470 synergizes with docetaxel (taxotere) and is cytotoxic to GIST cells. In the experiment, the researchers used many compounds, for example, N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3Electric Literature of C23H21N5O3S).

N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Electric Literature of C23H21N5O3S

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Efficacy and safety of rifaximin versus placebo or other active drugs in critical ill patients with hepatic encephalopathy was written by Han, Xianghui;Luo, Zhanyang;Wang, Wenyi;Zheng, Peiyong;Li, Tian;Mei, Zubing;Wang, Jianyi. And the article was included in Frontiers in Pharmacology in 2021.Application In Synthesis of (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione This article mentions the following:

Objective: Rifaximin has been approved for use as a first-line therapy for secondary prophylaxis of hepatic encephalopathy (HE). This article is to update existing evidence on efficacy and safety of rifaximin treatment and prevention for HE. We systematically searched multiple databases until Jan. 31 2021. The studies compared rifaximin vs. placebo or other active drugs (i.e., nonabsorbable disaccharides, other antibiotics, L-ornithine-L-aspartate (LOLA), and probiotics) for patients with overt HE (OHE), minimal HE (MHE), and recurrent HE. Twenty-eight randomized controlled trials with a total of 2979 patients were included. Compared with the controls, rifaximin significantly reduced HE grade (OHE: RR = 1.11, 95% CI = 1.02-1.21), improved the cognitive impairments (MHE: RR = 1.82, 95% CI = 1.12-2.93) and prevented the risk of HE recurrent episodes (RR = 1.33, 95% CI = 1.18-1.49). No statistical difference was observed in mortality between rifaximin and their controls (RR = 0.82, 95% CI = 0.54-1.24). The incidence of total adverse events in rifaximin-treated groups was significantly lower than that in the controls during the treatment period (RR = 0.73, 95% CI = 0.54-0.98). In addition, rifaximin treatment was better than other active drugs in improving psychometric indicators (mental state, flapping tremor and portosystemic encephalopathy (PSE) index) and reducing the risk of rehospitalization in HE patients. Conclusion: Rifaximin therapy is effective and well-tolerated in different types of HE, which might be recommended as an alternative to conventional oral drugs in clin. settings. In the experiment, the researchers used many compounds, for example, (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4Application In Synthesis of (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione).

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application In Synthesis of (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem