Bort, Guillaume et al. published their research in European Journal of Medicinal Chemistry in 2014 | CAS: 200115-86-2

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.SDS of cas: 200115-86-2

Gadolinium-based contrast agents targeted to amyloid aggregates for the early diagnosis of Alzheimer’s disease by MRI was written by Bort, Guillaume;Catoen, Sarah;Borderies, Helene;Kebsi, Adel;Ballet, Sebastien;Louin, Gaelle;Port, Marc;Ferroud, Clotilde. And the article was included in European Journal of Medicinal Chemistry in 2014.SDS of cas: 200115-86-2 This article mentions the following:

While important efforts were made in the development of positron emission tomog. (PET) tracers for the in vivo mol. diagnosis of Alzheimer’s disease, very few investigations to develop magnetic resonance imaging (MRI) probes were performed. Here, a new generation of Gd(III)-based contrast agents (CAs) is proposed to detect the amyloid β-protein (Aβ) aggregates by MRI, one of the earliest biol. hallmarks of the pathol. A building block strategy was used to synthesize a library of 16 CAs to investigate structure-activity relationships (SARs) on physicochem. properties and binding affinity for the Aβ aggregates. Three types of blocks were used to modulate the CA structures: (i) the Gd(III) chelates (Gd(III)-DOTA and Gd(III)-PCTA), (ii) the biovectors (2-arylbenzothiazole, 2-arylbenzoxazole and stilbene derivatives) and (iii) the linkers (neutrals, positives and negatives with several lengths). These investigations revealed unexpected SARs and a difficulty of these probes to cross the blood-brain barrier (BBB). General insights for the development of Gd(III)-based CAs to detect the Aβ aggregates are described. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2SDS of cas: 200115-86-2).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.SDS of cas: 200115-86-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem