Month: November 2022

Koganovskii, A. M. published the artcileAdsorption on silica gel of nonionic surfactants with solubilized substances from aqueous solutions, Category: benzofurans, the publication is Kolloidnyi Zhurnal (1975), 37(3), 560-4, database is CAplus.

At 20°, the adsorption of nonionogenic surfactants C10H21O(C2H4O)17H, C12H25O(C2H4O)17H, C12H25O(C2H4O)23H, and OP-10 from aqueous solutions containing solubilized α-naphtholphthalein (I) or naphthalene (II) on large-pore silica gel was higher than from solutions without the solubilized compounds The aqueous solutions of the surfactants were saturated with I or II by shaking at constant temperature for 15 days. The I and II did not adsorb from diethylene glycol, aqueous saturated solution of poly(ethylene glycol), or undecane solutions without surfactants. These compounds adsorb in the surface layer of the adsorbed surfactants making the outer-adsorbed layer more hydrophobic which results in an addnl. adsorption of the surfactants.

Kolloidnyi Zhurnal published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Lee, Yu-Jin published the artcileIsolation and identification of antioxidant polyphenolic compounds in mulberry (Morus alba L.) seeds, Category: benzofurans, the publication is Han’guk Sikp’um Yongyang Kwahak Hoechi (2011), 40(4), 517-524, database is CAplus.

Eleven polyphenolic compounds, including procatechuic and chlorogenic acids, (+)-dihydroquercetin, rutin, isoquercitrin, quercitrin, (+)-dihydrokaempferol, trans-resveratrol, moracin, quercetin and 4-prenylmoracin were isolated and purified from the methanolic extract of defatted mulberry seed residue by a series of column chromatog. including silica gel, Sephadex LH-20, and ODS-A, and their chem. structures were identified by spectral anal. The antioxidant activities of the eleven isolated polyphenolic compounds were measured spectrophotometrically using DPPH radical. Among the eleven polyphenolic compounds tested, rutin (IC₅₀=20.2 μM), isoquercitrin (IC₅₀=22.5 μM), quercitrin (IC₅₀=24.6 μM), quercetin (IC₅₀=27.8 μM), (+)-dihydroquercetin (IC₅₀=28.9 μM), and chlorogenic acid (IC₅₀=30.6 μM) exhibited stronger antioxidant activity than L-ascorbic acid (IC₅₀=31.5 μM) and α-tocopherol (IC₅₀=52.3 μM), whereas procatechuic acid (IC₅₀=68.2 μM) showed lower activity. In addition, (+)-dihydrokaempferol (IC₅₀=33.8 μM), trans-resveratrol (IC₅₀=36.2 μM), moracin (IC₅₀=47.6 μM), and 4-prenylmoracin (IC₅₀=48.2 μM) exhibited moderate antioxidant activity. Furthermore, levels of the eleven polyphenolic compounds from three different types of mulberry seeds were quantified by HPLC, and their contents were as follows: rutin (31.1-60.0 mg/100 g)> quercitrin (7.2-34.2 mg/100 g)> (+)-dihydroquercetin (13.2-33.1 mg/100 g)> quercetin (15.8-19.5 mg/100 g)> 4-prenylmoracin (10.5-43.3 mg/100 g)> isoquercitrin (5.8-15.4 mg/100 g)> chlorogenic acid (0.0-15.3 mg/100 g)> moracin (4.7-7.2 mg/100 g)> procatechuic acid (0.0-11.6 mg/100 g)> (+)-dihydrokaempferol and trans-resveratrol (<0.1 mg/100 g). The ‘Daesungppong’ mulberry seeds among the three cultivars had higher flavonoid contents, such as rutin and quercetin derivatives, while the ‘Iksuppong’ seeds had the highest contents of phenolic acids and moracin derivatives ‘Cheongilppong’ had lower amounts of polyphenolic compounds than the other two mulberry seeds. These results indicate that mulberry seeds containing antioxidant polyphenolic compounds may be potentially useful sources of anti-diabetic, anti-hypertensive, and anti-aging agents for functional foods and cosmetics.

Han’guk Sikp’um Yongyang Kwahak Hoechi published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Okura, Keisho published the artcileSingle electron transfer-induced coupling of alkynylzinc reagents with aryl and alkenyl iodides, Application of 2-Iodobenzofuran, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(97), 14019-14022, database is CAplus and MEDLINE.

Alkynylzinc reagents were found to undergo coupling with aryl and alkenyl iodides to give arylalkynes and alkenylalkynes without the aid of transition metals. The coupling reaction proceeded through a single electron transfer mechanism, where a substoichiometric amount of a phosphine works as an indispensable activator.

Chemical Communications (Cambridge, United Kingdom) published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Application of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Park, Ji-Hae published the artcileTwo new isoarylbenzofuran diglucosides from the root bark of Morus alba, Synthetic Route of 56317-21-6, the publication is Journal of Asian Natural Products Research (2015), 17(4), 357-363, database is CAplus and MEDLINE.

Two new arylbenzofuran diglucopyranosides, (2”R)-(-)-moracin-O-5′,3”-β-D-diglucopyranoside (1) and (2”R)-(-)-moracin-P-5′,2”-β-D-diglucopyranoside (2), along with known arylbenzofurans, moracin M 6-β-D-glucopyranoside (3), and an isomeric mixture of R-(-)-moracin O (4) and R-(-)-moracin P (5), were isolated from the root bark of Morus alba L. The structure of the compounds was elucidated based on mass spectrometry, IR, 1D and 2D NMR spectroscopic data.

Journal of Asian Natural Products Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Synthetic Route of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Chen, Doris published the artcileIntramolecular, Interrupted Homo-Nazarov Cascade Biscyclizations to Angular (Hetero)Aryl-Fused Polycycles, Recommanded Product: 2-Iodobenzofuran, the publication is Chemistry – A European Journal, database is CAplus and MEDLINE.

A SnCl₄-catalyzed intramol., interrupted homo-Nazarov cascade biscyclization to access angular (hetero)aryl-fused polycycles was reported. Subsequent decarboxylation of the readily enolizable products afforded the angular products in up to 71 % yield over two steps, with the trans-diastereomers as the major products. The cyclopropyl homo-Nazarov cyclization precursors were formed using a scalable and modular synthetic route that, ultimately, offers access to 6,6,6-, 6,6,5-, 6,5,6-, 6,6,5,6-, and 6,6,6,5-fused angular polycyclic products. To showcase the rigor and utility of the method, an 8-step total synthesis of (±)-1-oxoferruginol, an antibacterial aromatic abietane diterpenoid, was disclosed.

Chemistry – A European Journal published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Recommanded Product: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Jeong, Ji Yeon published the artcilePancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions, HPLC of Formula: 56317-21-6, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(11), 2269-2274, database is CAplus and MEDLINE.

The leaves of Morus alba (Moraceae) have been traditionally used for the treatment of metabolic diseases including diabetes and hyperlipidemia. Thus, inhibitory effect of M. alba leaves on pancreatic lipase and their active constituents were investigated in this study. Twenty phenolic compounds including ten flavonoids, eight benzofurans, one stilbene and one chalcones were isolated from the leaves of M. alba. Among the isolated compounds, morachalcone A (20) exerted strong pancreatic lipase inhibition with IC₅₀ value of 6.2 μM. Other phenolic compounds containing a prenyl group showed moderate pancreatic lipase inhibition with IC₅₀ value of <50 μM. Next, extraction conditions with maximum pancreatic lipase inhibition and phenolic content were optimized using response surface methodol. with three-level-three-factor Box-Behnken design. Our results suggested the optimized extraction condition for maximum pancreatic lipase inhibition and phenolic content as ethanol concentration of 74.9%; temperature 57.4 °C and sample/solvent ratio, 1/10. The pancreatic lipase inhibition and total phenolic content under optimized condition were found to be 58.5% and 26.2 μg GAE (gallic acid equivalent)/mg extract, resp., which were well matched with the predicted value.

Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Li, Hong Xu published the artcileLipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes, Related Products of benzofurans, the publication is Natural Product Research (2018), 32(16), 1963-1966, database is CAplus and MEDLINE.

In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds and showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, resp. In addition, compounds , and showed significant inhibitory activity with values from 15.4 to 21.2% and compounds , – and – exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochem. source against lipid accumulation.

Natural Product Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Dat, Nguyen Tien published the artcileHypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived Diels-Alder adducts from Morus species, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Journal of Natural Products (2009), 72(1), 39-43, database is CAplus and MEDLINE.

Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen concentrations and vital to many aspects of cancer biol. Bioassay-guided fractionation of the chloroform-soluble extracts of Morus species using a hypoxia response element (HRE)-dependent reporter assay led to identification of six benzofurans (1-6) and two chalcone-derived Diels-Alder adducts (7, 8) from Mori Cortex Radicis and three prenylated benzofurans (9-11) and four chalcone-derived Diels-Alder adducts (12-15) from Morus bombycis. The structure of the new 2-arylbenzofuran-type compound, moracin Q (3), was elucidated by spectroscopic methods, and the absolute configuration of 2 was determined for the first time. The selected compounds (1-3, 5, 7, 9, 10, and 12) from the cell-based reporter assay were found to inhibit hypoxia-induced HIF-1α accumulation in a dose-dependent manner in human hepatocelluar carcinoma cell-line Hep3B cells. Furthermore, these compounds were also active against hypoxia-induced vascular endothelial growth factor (VEGF) secretion in Hep3B cells.

Journal of Natural Products published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fan, Huiru published the artcileSulfur (VI) Fluoride Exchange Polymerization for Large Conjugate Chromophores and Functional Main-Chain Polysulfates with Nonvolatile Memory Performance, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is ChemPlusChem (2018), 83(5), 407-413, database is CAplus and MEDLINE.

Sulfur (VI) fluoride exchange (SuFEx) reactions can be applied not only in organic click synthesis, but also in the preparation of functional main-chain polymers. In this work, four functional main-chain polysulfates (PNT-PS, NPNT-PS, PHF-PS, and TPE-PS) are synthesized in high yield using the SuFEx reaction at room temperature The polysulfates exhibit satisfactory thermal stability and solution processability. They are used as the active layer for memory devices (ITO/PNT-PS/Al, ITO/NPNT-PS/Al, ITO/PHF-PS/Al, and ITO/TPE-PS/Al). I-V measurements show that ITO/PNT-PS/Al and ITO/NPNT-PS/Al exhibit stable flash-memory (write-read-erase) behavior, while ITO/PHF-PS/Al and ITO/TPE-PS/Al exhibit WORM (write once read many) behavior. Our studies provide a feasible and efficient synthetic methodol. for the preparation of new memory materials.

ChemPlusChem published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kang, Yu Jin published the artcileA zig-zag type bidibenzofuran based host material for green phosphorescent organic light-emitting diodes, Recommanded Product: 2-Iodobenzofuran, the publication is Dyes and Pigments (2015), 278-282, database is CAplus.

A zig-zag type carbazole modified bidibenzofuran compound, 2,2′-di(carbazol-9-yl)-4,4′-bidibenzo[b,d]furan, was synthesized as the host material for green phosphorescent organic light-emitting diodes by coupling 2 9-(dibenzo[b,d]furan-2-yl)carbazole moieties via 4- position of dibenzofuran. The carbazole modified bidibenzofuran host showed a triplet energy of 2.75 eV and the HOMO/the LUMO of -6.10 eV/-2.87 eV for hole and electron injection. The bidibenzofuran host was doped with green emitting tris(2-phenylpyridine) Ir and high quantum efficiency of 20.6% was achieved in the green phosphorescent organic light-emitting diodes.

Dyes and Pigments published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Recommanded Product: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem