Month: October 2021

In 2019 SCI CHINA CHEM published article about ASYMMETRIC CONJUGATE ADDITION; CARBOXYLIC-ACIDS; FACILE ACCESS; QUATERNARY; DIHYDRONAPHTHOQUINONES; BENZOFURAN-2(3H)-ONES; BENZOFURAN-2-ONES; STEREOCENTERS; DERIVATIVES; CYCLIZATION in [Wang, Jie; Li, Xin; Cheng, Jin-Pei] Nankai Univ, State Key Lab Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn, Coll Chem, Tianjin 300071, Peoples R China in 2019, Cited 44. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Quality Control of Isobenzofuran-1(3H)-one

A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3- substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were synthesized in moderate to good yields (up to 96%) with high diastereoselectivities (up to >19:1 dr) and enantioselectivities (up to 96:4 er).

Quality Control of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, J; Li, X; Cheng, JP or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: Isobenzofuran-1(3H)-one. Authors Wang, CQ; Liu, G; Dou, GJ; Yang, Y; Chen, L; Ma, H; Jiang, ZY; Ma, HY; Li, CL; Li, L; Jiang, MD; Lu, QW; Li, P; Qi, HY in ELSEVIER GMBH published article about in [Wang, Chengqiang; Liu, Gen; Dou, Guojun; Yang, Yi; Chen, Lu; Ma, Hui; Jiang, Zhuyun; Ma, Haoyue; Li, Li; Qi, Hongyi] Southwest Univ, Coll Pharmaceut Sci, 2 Tiansheng Rd, Chongqing 400715, Peoples R China; [Wang, Chengqiang; Liu, Gen; Dou, Guojun; Yang, Yi; Chen, Lu; Ma, Hui; Jiang, Zhuyun; Ma, Haoyue; Li, Li; Qi, Hongyi] Southwest Univ, Coll Chinese Med, 2 Tiansheng Rd, Chongqing 400715, Peoples R China; [Li, Chenglong] Sichuan Prov Peoples Hosp, Dept Hematol, Chengdu 610212, Sichuan, Peoples R China; [Jiang, Mingdong; Lu, Qianwei; Li, Pan] Chongqing Ninth Peoples Hosp, Dept Oncol & Hematol, Jialing Village 69, Chongqing 400700, Peoples R China in 2021, Cited 24. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Background: Acute myeloid leukemia (AML) is a devastating hematologic malignancy with a high mortality. The nuclear receptors Nur77 and NOR-1 are commonly downregulated in human AML blasts and have emerged as key therapeutic targets for AML. Methods: This study aimed to identify Z-ligustilide (Z-LIG), the main phthalide of Rhizoma Chuanxiong, as a potential agent that can selectively target AML. The anti-AML activity of Z-LIG was evaluated in vitro and in vivo, and the effect and underlying mechanisms of Z-LIG on the restoration of Nur77 and NOR-1 was determined. Moreover, the role of Nur77 and NOR-1 in the regulation of Z-LIG-induced apoptosis and differentiation of AML cells was explored. Results: Z-LIG preferentially inhibited the viability of human AML cells, as well as suppressed the proliferation and colony formation ability. Notably, a concentration-dependent dual effect of Z-LIG was observed in AML cells: inducing apoptosis at relatively high concentrations (25 mu M to 100 mu M) and promoting differentiation at relatively low concentrations (10 mu M and 25 mu M). Importantly, Z-LIG restored Nur77 and NOR-1 expression in AML cells by increasing Ace-H3 (lys9/14) enrichment in their promoters. Meanwhile, Z-LIG enhanced the recruitment of p300 and reduced the recruitment of HDAC1, HDAC4/5/7, and MTA1 in the Nur77 promoter and enhanced the recruitment of p-CREB and reduced HDAC1 and HDAC3 in the NOR-1 promoter. Furthermore, Z-LIG-induced apoptosis was shown to be correlated with the mitochondria localization of Nur77/NOR-1 and subsequent Bcl-2 conformational change, converting Bcl-2 from a cyto-protective phenotype into a cyto-destructive phenotype. ZLIG-promoted differentiation was found to be related to Nur77/NOR-1-mediated myeloid differentiation-associated transcription factors Jun B, c-Jun, and C/EBP beta. Finally, silencing of Nur77 and NOR-1 attenuated anti-AML activity of Z-LIG in NOD/SCID mice. Conclusions: Our study suggests that Z-LIG may serve as a novel bifunctional agent for AML by restoring Nur77/NOR-1-mediated apoptosis and differentiation

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article A g-C3N4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C-H oxygenations published in 2019. COA of Formula: C8H6O2, Reprint Addresses Hu, JC (corresponding author), Chongqing Normal Univ, Coll Chem, Chongqing 401331, Peoples R China.; Cai, YF (corresponding author), Chongqing Univ, Sch Chem & Chem Engn, 174 Shazheng St, Chongqing 400030, Peoples R China.; Cai, YF (corresponding author), Chongqing Univ, Chongqing Key Lab Theoret & Computat Chem, 174 Shazheng St, Chongqing 400030, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C3N4) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biologically valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this green methodology was further demonstrated by applying in bioactive and drug valued target syntheses.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Geng, PX; Tang, YR; Pan, GT; Wang, WT; Hu, JC; Cai, YF or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about RESAZURIN, Saw an article supported by the Thailand Research Fund (TRF)Thailand Research Fund (TRF) [RSA6280019]; National Center for Genetic Engineering and Biotechnology (BIOTEC grant) [P19-50917]. Published in ELSEVIER in AMSTERDAM ,Authors: Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Quality Control of Isobenzofuran-1(3H)-one

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about P2X(1) ION-CHANNEL; MOUSE MODEL; ATP; ACTIVATION; EXPRESSION; RESPONSES; NF449; INHIBITOR; PHARMACOLOGY; NUCLEOTIDES, Saw an article supported by the BMBF (German Federal Ministry for Education and Research) within the BioPharma initiative NeuroallianzFederal Ministry of Education & Research (BMBF); Arab-German Young Academy of Sciences and Humanities (AGYA); CONICYT/FONDECYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [1180427]. Recommanded Product: 87-41-2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 mu M) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 mu M), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

Recommanded Product: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. Recently I am researching about CARBON; NANOPARTICLES; COSIX/CNTS; XPS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21373038, 21403026]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [DUT18GJ206]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhang, LL; Chen, X; Chen, YJ; Peng, ZJ; Liang, CH. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Chemoselective hydrogenation of phthalic anhydride is regarded as the most promising route for producing downstream high-performance phthalide. A series of intermetallic cobalt-nickel silicide catalysts embedded in a carbon matrix (CoxNi2-xSi@C) with acid-tolerance prepared by microwave-assisted chemical vapor deposition have been investigated in this reaction system. Activity measurements show a remarkable positive synergistic effect, forming a volcano-shaped plot over the nominal Co metal fraction for CoxNi2-xSi@C catalysts with a peak at x = 1.5, which corresponds to a 4.5-fold enhancement of the yield of phthalide over Co2Si@C and a 2.0-fold enhancement over the Ni2Si@C monometallic silicide catalysts, which can be correlated with the interaction of cobalt-nickel and metal-silicon bonds. In addition, the cobalt-rich bimetallic silicide exhibits an equal activity to the reference noble metal catalysts (Au, Pd, and Pt) and a significantly higher activity than transition metal catalysts. Moreover, the bimetallic silicide as an intermetallic compound catalyst has demonstrated robust acid corrosion resistance compared to the corresponding metal catalysts.

Computed Properties of C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhang, LL; Chen, X; Chen, YJ; Peng, ZJ; Liang, CH or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2021 GREEN CHEM published article about IRIDIUM COORDINATION POLYMERS; GAMMA-VALEROLACTONE; BIOMASS; CONVERSION; PLATFORM; RU; NANOSHEETS; COMPLEXES; CHEMICALS; PRODUCTS in [Shen, Lingyun; Zheng, Qingshu; Liu, Yaoqi; Wu, Jiajie; Lu, Zeye; Tu, Tao] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China; [Tu, Tao] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China; [Tu, Tao] Zhengzhou Univ, Green Catalysis Ctr, 100 Kexue Ave, Zhengzhou 450001, Peoples R China; [Tu, Tao] Zhengzhou Univ, Coll Chem, 100 Kexue Ave, Zhengzhou 450001, Peoples R China in 2021, Cited 60. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

A practical, efficient, and mild hydrogenation of levulinic acid (LA) to gamma-valerolactone (GVL) under 1 atm H-2 was realized by single-sited 3D porous self-supported N-heterocyclic carbene iridium catalysts. Quantitative yields and selectivities were achieved at 0.02 mol% catalyst loading, and the catalyst could be reused for 9 runs without obvious loss of selectivity or activity.

HPLC of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Shen, LY; Zheng, QS; Liu, YQ; Wu, JJ; Lu, ZY; Tu, T or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 CHEM ENG J published article about VOLATILE ORGANIC-COMPOUNDS; ENHANCED PHOTOCATALYTIC ACTIVITY; VISIBLE-LIGHT PHOTOCATALYSIS; TOTAL-ENERGY CALCULATIONS; TITANIUM-DIOXIDE; CATALYTIC COMBUSTION; INDOOR AIR; OXIDATION; PHOSPHATE; REMOVAL in [Wang, Zhuang; Mahmood, Asad; Xie, Xiaofeng; Wang, Xiao; Sun, Jing] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China; [Wang, Zhuang; Qiu, Hanxun] Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China in 2020, Cited 75. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Safety of Isobenzofuran-1(3H)-one

For the oxide-based photocatalysts, polyoxylic acid modification can affect their adsorption/desorption properties and further regulate photocatalytic reaction pathway, which is crucial for enhancing photocatalytic activity and selectivity. Herein, phosphoric acid modified TiO2 was synthesized by a facile impregnation-calcination method for photocatalytic degradation of gaseous o-xylene. According to FTIR, XPS, and EDS analysis, phosphoric acid was anchored on the surface of TiO2 successfully. The surface P atomic percentages for PT1 was 2.45%. The as-prepared phosphoric acid modified TiO2 (PTx) had a photocatalytic performance superior to that of commercial TiO2 and unmodified TiO2 (PT0), with increasing by 2.2 times at most. Interestingly, the phosphoric acid molecules strongly adsorbed on anatase TiO2 surface by forming H-O-2C and =O-Ti-5C chemical bonds according to the first principle calculations, which changed TiO2 surface properties (specific surface area and surface negative electrostatic field) and further improved adsorption and charge carrier separation and transfer, thus improving the photocatalytic activity. Additionally, according to the intermediates results, the relative abundance of intermediates shows obvious difference. Acetone was detected as the most abundant intermediates during o-xylene degradation for PT0, whereas that was o-methyl benzaldehyde for PT1, which could be ascribed to the difference of surface adsorption configuration of o-xylene. According to the temperature-programmed desorption (TPD) results, the surface modified by phosphoric acid could change the o-xylene adsorption configuration to favor its methyl oxidation (standing configuration), whereas the unmodified surface could be more favorable to the benzene ring-open reaction (lying configuration). This work will deepen the understanding of the relevance of surface modification and surface photocatalytic reaction, which also provides a feasible strategy to improve photocatalytic selectivity.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

SDS of cas: 87-41-2. Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C in [Zhang, Qiaohong; He, Honghao; Wang, Huibin; Chen, Chen] Ningbo Univ, Sch Mat Sci & Chem Engn, 818 Fenghua Rd, Ningbo 315211, Peoples R China; [Zhang, Zhan] China Tobacco Henan Ind Co Ltd, 8 3rd Ave, Zhengzhou 450001, Peoples R China published Efficient catalytic oxidation of methyl aromatic hydrocarbon with N-alkyl pyridinium salts in 2019, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A series of N-alkyl pyridinium salts were synthesized and employed as metal-free catalyst for the selective oxidation of methyl aromatic hydrocarbon with molecular oxygen. The electronic effect of the substitutes was found to be an important factor for the catalytic performance. With the introduction of electron-donating substitute -N(CH3)(2), the conversion of p-xylene and selectivity of p-toluic acid could be simultaneously increased. 1-Benzyl-4-N,N-dimethylaminopyridinium salt showed the highest catalytic activity, and 95% conversion with 84% of selectivity to p-toluic acid could be obtained for the selective oxidation of p-xylene. Several methyl aromatic hydrocarbons could all be efficiently oxidized with the reported catalyst at the absence of any metal species.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C or concate me.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters WOS:000589715100001 published article about ENANTIOSELECTIVE C-ACYLATION; SECONDARY ALCOHOLS; DERIVATIVES in [Zhou, Muxing; Zhang, Zhenfeng; He, Ende; Liu, Yangang; Zhang, Wanbin] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Gridneva, Tatiana; Zhang, Wanbin] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China in 2021, Cited 47. Recommanded Product: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-pi interactions and not the previously considered cation/pi-pi interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhou, MX; Gridneva, T; Zhang, ZF; He, ED; Liu, YG; Zhang, WB or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem