Day: October 25, 2021

Recommanded Product: 87-41-2. Authors Wang, CQ; Liu, G; Dou, GJ; Yang, Y; Chen, L; Ma, H; Jiang, ZY; Ma, HY; Li, CL; Li, L; Jiang, MD; Lu, QW; Li, P; Qi, HY in ELSEVIER GMBH published article about in [Wang, Chengqiang; Liu, Gen; Dou, Guojun; Yang, Yi; Chen, Lu; Ma, Hui; Jiang, Zhuyun; Ma, Haoyue; Li, Li; Qi, Hongyi] Southwest Univ, Coll Pharmaceut Sci, 2 Tiansheng Rd, Chongqing 400715, Peoples R China; [Wang, Chengqiang; Liu, Gen; Dou, Guojun; Yang, Yi; Chen, Lu; Ma, Hui; Jiang, Zhuyun; Ma, Haoyue; Li, Li; Qi, Hongyi] Southwest Univ, Coll Chinese Med, 2 Tiansheng Rd, Chongqing 400715, Peoples R China; [Li, Chenglong] Sichuan Prov Peoples Hosp, Dept Hematol, Chengdu 610212, Sichuan, Peoples R China; [Jiang, Mingdong; Lu, Qianwei; Li, Pan] Chongqing Ninth Peoples Hosp, Dept Oncol & Hematol, Jialing Village 69, Chongqing 400700, Peoples R China in 2021, Cited 24. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Background: Acute myeloid leukemia (AML) is a devastating hematologic malignancy with a high mortality. The nuclear receptors Nur77 and NOR-1 are commonly downregulated in human AML blasts and have emerged as key therapeutic targets for AML. Methods: This study aimed to identify Z-ligustilide (Z-LIG), the main phthalide of Rhizoma Chuanxiong, as a potential agent that can selectively target AML. The anti-AML activity of Z-LIG was evaluated in vitro and in vivo, and the effect and underlying mechanisms of Z-LIG on the restoration of Nur77 and NOR-1 was determined. Moreover, the role of Nur77 and NOR-1 in the regulation of Z-LIG-induced apoptosis and differentiation of AML cells was explored. Results: Z-LIG preferentially inhibited the viability of human AML cells, as well as suppressed the proliferation and colony formation ability. Notably, a concentration-dependent dual effect of Z-LIG was observed in AML cells: inducing apoptosis at relatively high concentrations (25 mu M to 100 mu M) and promoting differentiation at relatively low concentrations (10 mu M and 25 mu M). Importantly, Z-LIG restored Nur77 and NOR-1 expression in AML cells by increasing Ace-H3 (lys9/14) enrichment in their promoters. Meanwhile, Z-LIG enhanced the recruitment of p300 and reduced the recruitment of HDAC1, HDAC4/5/7, and MTA1 in the Nur77 promoter and enhanced the recruitment of p-CREB and reduced HDAC1 and HDAC3 in the NOR-1 promoter. Furthermore, Z-LIG-induced apoptosis was shown to be correlated with the mitochondria localization of Nur77/NOR-1 and subsequent Bcl-2 conformational change, converting Bcl-2 from a cyto-protective phenotype into a cyto-destructive phenotype. ZLIG-promoted differentiation was found to be related to Nur77/NOR-1-mediated myeloid differentiation-associated transcription factors Jun B, c-Jun, and C/EBP beta. Finally, silencing of Nur77 and NOR-1 attenuated anti-AML activity of Z-LIG in NOD/SCID mice. Conclusions: Our study suggests that Z-LIG may serve as a novel bifunctional agent for AML by restoring Nur77/NOR-1-mediated apoptosis and differentiation

Recommanded Product: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, CQ; Liu, G; Dou, GJ; Yang, Y; Chen, L; Ma, H; Jiang, ZY; Ma, HY; Li, CL; Li, L; Jiang, MD; Lu, QW; Li, P; Qi, HY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Name: Isobenzofuran-1(3H)-one. Rysak, V; Dixit, R; Trivelli, X; Merle, N; Agbossou-Niedercorn, F; Vanka, K; Michon, C in [Rysak, Vincent; Merle, Nicolas; Agbossou-Niedercorn, Francine; Michon, Christophe] Univ Lille, Univ Artois, UMR 8181 UCCS Unite Catalyse & Chim Solide, Cent Lille,CNRS, F-59000 Lille, France; [Dixit, Ruchi; Vanka, Kumar] Natl Chem Lab, Phys & Mat Chem Div, CSIR, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Dixit, Ruchi] Acad Sci & Innovat Res AcSIR, Ghaziahad 201002, India; [Trivelli, Xavier] Univ Lille, Univ Artois, Cent Lille, FR 2638 IMEC Inst Michel Eugene Chevreul,CNRS,INR, F-59000 Lille, France; [Michon, Christophe] Univ Strasbourg, Univ Haute Alsace, Ecole Europeenne Chim Polymeres & Mat, CNRS,LIMA,UMR 7042, 25 Rue Becquerel, F-67087 Strasbourg, France published Catalytic reductive deoxygenation of esters to ethers driven by hydrosilane activation through non-covalent interactions with a fluorinated borate salt in 2020, Cited 117. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

We report the catalytic and transition metal-free reductive deoxygenation of esters to ethers through the use of a hydrosilane and a fluorinated borate BArF salt as a catalyst. Experimental and theoretical studies support the role of noncovalent interactions between the fluorinated catalyst, the hydrosilane and the ester substrate in the reaction mechanism.

Name: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Rysak, V; Dixit, R; Trivelli, X; Merle, N; Agbossou-Niedercorn, F; Vanka, K; Michon, C or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Wang, RY; Wu, ZW; Li, ZK; Qin, ZF; Chen, CM; Zheng, ZF; Wang, GF; Fan, WB; Wang, JG in ELSEVIER SCIENCE BV published article about ACID IONIC LIQUIDS; EFFICIENT SYNTHESIS; CHEMICAL-EQUILIBRIUM; METHANOL; REDUCTION; SITES; OME; PARAFORMALDEHYDE; IMPROVEMENT; TRIOXANE in [Wang, Ruiyi; Wu, Zhiwei; Li, Zhikai; Qin, Zhangfeng; Chen, Chengmeng; Zheng, Zhanfeng; Wang, Guofu; Fan, Weibin; Wang, Jianguo] Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, POB 165, Taiyuan 030001, Shanxi, Peoples R China; [Chen, Chengmeng] Chinese Acad Sci, Inst Coal Chem, Key Lab Carbon Mat, Taiyuan 030001, Shanxi, Peoples R China in 2019, Cited 48. HPLC of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Polyoxymethylene dimethyl ethers (PODE, with the formula of CH3O-(CH2O)(n)-CH3), as a promising environmentally benign diesel fuel or additive with an enormous potential in the reduction of soot and NIC, emissions, can be efficiently synthesized from methanol derivatives such as dimethoxymethane (DMM) and trioxymethylene (TOM), which requests a proper catalyst of high performance. In this work, the catalytic performance of graphene oxide (GO) in the synthesis of PODEn as well as its relation to the catalyst structure was thoroughly investigated. The results indicate that GO is an excellent catalyst in the synthesis of PODEn from DMM and TOM; a TOM conversion of 94.6% and selectivity of 86.0% to PODE2-8 are achieved under mild reaction conditions, which is superior to the majority of the state-of-the-art catalysts. Meanwhile, the active species and characteristic layer structure of GO sheets catalytically responsible for PODEn formation were discriminated through selectively removing certain surface functional groups, thermally annealing at different temperatures, and carefully comparing with a series of model compounds. The results illustrate that the superior catalytic performance of GO in the PODEn synthesis should be ascribed to a synergy between the surface sulfonyl, hydroxyl and carboxyl groups present on the GO surface and the unique layered structure of GO sheets, wherein the surface sulfonyl groups act as the main active sites. The insights shown in this work are beneficial to a deep understanding on the catalytic principle of GO and development of efficient catalyst for the synthesis of PODEn.

HPLC of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, RY; Wu, ZW; Li, ZK; Qin, ZF; Chen, CM; Zheng, ZF; Wang, GF; Fan, WB; Wang, JG or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. Takakura, R; Ban, K; Sajiki, H; Sawama, Y in [Takakura, Ryoya; Ban, Kazuho; Sajiki, Hironao; Sawama, Yoshinari] Gifu Pharmaceut Univ, Lab Organ Chem, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan published Platinum-on-Carbon-Catalyzed Aqueous Oxidative Lactonization of Diols by Using Molecular Oxygen in 2019, Cited 49. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A lactonization of various diols catalyzed by platinum on carbon (Pt/C) in water under an atmosphere of molecular oxygen was developed. Derivatives of 1,4- 1,5- and 1,6-diols were transformed into the corresponding five-, six-, and seven-membered lactones by the present oxidative lactonization method.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Takakura, R; Ban, K; Sajiki, H; Sawama, Y or concate me.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Selective aerobic oxidation of cyclic ethers to lactones over Au/CeO2 without any additives WOS:000518591800023 published article about COPPER(II) COMPLEXES; CATALYTIC-OXIDATION; TETRAHYDROFURAN; FUNCTIONALIZATION; CLUSTERS in [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Chen, Bingfeng; Han, Buxing; Liu, Huizhen] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid & Interface, Beijing 100190, Peoples R China; [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Chen, Bingfeng; Han, Buxing; Liu, Huizhen] Chinese Acad Sci, Thermodynam Inst Chem, Beijing 100190, Peoples R China; [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Han, Buxing; Liu, Huizhen] Univ Chinese Acad Sci, Beijing 100149, Peoples R China in 2020, Cited 40. Quality Control of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Selective oxidation of ethers to lactones with O-2 as a benign oxidant using Au/CeO2 as the catalyst has been developed. The oxygen vacancies and Au-0 species on the surface of CeO2 contribute to the activation of O-2. The excellent selectivity of lactones is due to the adsorption of ethers and activation of the C(sp(3))-H bond on Au/CeO2.

Quality Control of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Liu, SL; Li, SP; Shen, XJ; Wang, YY; Du, J; Chen, BF; Han, BX; Liu, HZ or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 J CLEAN PROD published article about ADVANCED OXIDATION PROCESSES; AQUEOUS-SOLUTION; WASTE-WATER; PHOTOCHEMICAL DEGRADATION; HYDROXYL RADICALS; HYDROGEN-PEROXIDE; AZO-DYE; MECHANISM; REMOVAL; KINETICS in [Lu, Chao; Yao, Jun; Amde, Meseret; Gu, Jihai; Liu, Jianli; Li, Hao] China Univ Geosci Beijing, Res Ctr Environm Sci & Engn, Sch Water Resource & Environm, 29 Xueyuan Rd, Beijing 100083, Peoples R China; [Knudsen, Tatjana Solevic] Univ Belgrade, Inst Chem Technol & Met, Njegoseva 12, Belgrade 11000, Serbia; [Amde, Meseret] Haramaya Univ, Coll Nat & Computat Sci, Dept Chem, POB 138, Dire Dawa, Ethiopia; [Zhang, Junyang] Curtin Univ, Western Australia Sch Mines, Dept Min & Met Engn, Kalgoorlie, WA, Australia in 2019, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Category: benzofurans

Flotation reagents, especially new chelating agents represented by alpha-nitroso-beta-naphthol, are the main components of cobalt mining drainage. This study reports the degradation of alpha-nitroso-beta-naphthol by simulated UVA-B (280-400 nm) activated systems using three common oxidants, hydrogen peroxide, sodium persulfate and potassium monopersulfate at a laboratory scale using a photoreactor. Parameters which can affect the degradation process were investigated and comparison of the degradation performance of the three systems were made. Based on the results, UVA-B/sodium persulfate system exhibited best performance towards the removal of alpha-nitroso-beta-naphthol with a lower cost of oxidant and energy consumption compared to the others. The removal efficiency was found to increase as the oxidant dosage and the UVA-B power increases. Only potassium monopersulfate could be activated by bicarbonate and chloride ions, and SO42- has insignificant effect on the removal efficiency of alpha-nitroso-beta-naphthol for all systems while NO3- inhibited the degradation of alpha-nitroso-beta-naphthol. In the UVA-B/hydrogen peroxide system, the hydroxyl radical had a leading role in the degradation of alpha-nitroso-beta-naphthol, while in the other two systems, the degradation of alpha-nitroso-beta-naphthol was mainly caused by the hydroxyl and sulphate radicals. Ten major intermediates from alpha-nitroso-beta-naphthol degradation in the three oxidation systems were identified by gas chromatography and mass spectrometry. In summary, this report could be a great input in developing UVA-B activated oxidants-based treatment technologies. The UVA-B/sodium persulfate system is strongly recommended for its consideration in the treatment of mine impacted wastewaters. (c) 2019 Elsevier Ltd. All rights reserved.

Category: benzofurans. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lu, C; Yao, J; Knudsen, TS; Amde, M; Gu, JH; Liu, JL; Li, H; Zhang, JY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Environmental Sciences & Ecology; Toxicology very interesting. Saw the article Investigation of the Potential Environmental Risks of Phthalate Derivatives Designed To Be Environmentally Friendly published in 2020. Application In Synthesis of Isobenzofuran-1(3H)-one, Reprint Addresses Li, Y (corresponding author), North China Elect Power Univ, Coll Environm Sci & Engn, Beijing, Peoples R China.; Li, Y (corresponding author), North China Elect Power Univ, State Key Lab Reg Optimizat Energy Syst, Beijing, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalate derivatives with low estrogenic activity, high infrared spectrum signals, high Raman characteristic vibration spectrum, high fluorescence intensity, and high ultraviolet sensitivity were selected as precursors from our previous studies, so that the changes in their toxicity and estrogenic activity during biological metabolism, ozone oxidation, photocatalytic degradation, photodegradation, and microbial degradation could be studied.The transformation pathways of these derivatives were simulated, and the reaction energy barriers were calculated. To determine the potential environmental risks of these phthalate derivatives, the pharmacophore models of biotoxicity and estrogen activity of phthalates were used to predict the biotoxicity and estrogen activity of the transformed products. The results showed an increase in the biotoxicity and estrogen activity of the biometabolites, ozonation products, photocatalytic degradation products, and microbial degradation products; the only products that did not follow this trend were the photodegradation products. Notably, the pathways that produced more potentially toxic compounds were the less favorable paths. Our results indicate that the transformation products of the designed environmentally friendly phthalate derivatives potentially pose environmental risks. To avoid such risks, the environmental transformation pathway of these derivatives should be simulated to screen for environmentally friendly phthalate molecules. Environ Toxicol Chem 2020;00:1-11. (c) 2020 SETAC

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhang, WH; Sun, RH; Hou, YL; Qiu, YL; Li, Y or concate me.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Acid-tolerant intermetallic cobalt-nickel silicides as noble metal-like catalysts for selective hydrogenation of phthalic anhydride to phthalide WOS:000460322700023 published article about CARBON; NANOPARTICLES; COSIX/CNTS; XPS in [Zhang, Liangliang; Chen, Xiao; Chen, Yujing; Liang, Changhai] Dalian Univ Technol, State Key Lab Fine Chem, Lab Adv Mat & Catalyt Engn, Sch Chem Engn, Dalian 116024, Peoples R China; [Zhang, Liangliang; Peng, Zhijian] China Univ Geosci, Sch Engn & Technol, Beijing 100083, Peoples R China in 2019, Cited 35. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

Chemoselective hydrogenation of phthalic anhydride is regarded as the most promising route for producing downstream high-performance phthalide. A series of intermetallic cobalt-nickel silicide catalysts embedded in a carbon matrix (CoxNi2-xSi@C) with acid-tolerance prepared by microwave-assisted chemical vapor deposition have been investigated in this reaction system. Activity measurements show a remarkable positive synergistic effect, forming a volcano-shaped plot over the nominal Co metal fraction for CoxNi2-xSi@C catalysts with a peak at x = 1.5, which corresponds to a 4.5-fold enhancement of the yield of phthalide over Co2Si@C and a 2.0-fold enhancement over the Ni2Si@C monometallic silicide catalysts, which can be correlated with the interaction of cobalt-nickel and metal-silicon bonds. In addition, the cobalt-rich bimetallic silicide exhibits an equal activity to the reference noble metal catalysts (Au, Pd, and Pt) and a significantly higher activity than transition metal catalysts. Moreover, the bimetallic silicide as an intermetallic compound catalyst has demonstrated robust acid corrosion resistance compared to the corresponding metal catalysts.

HPLC of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhang, LL; Chen, X; Chen, YJ; Peng, ZJ; Liang, CH or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Qian, SQ; Li, ZQ; Li, MY; Wisniewski, SR; Qiao, JX; Richter, JM; Ewing, WR; Eastgate, MD; Chen, JS; Yu, JQ in AMER CHEMICAL SOC published article about C-H FUNCTIONALIZATION; DERIVATIVES; ARYLATION; OXIDATION; ACTIVATION; BONDS in [Qian, Shaoqun; Li, Zi-Qi; Li, Minyan; Yu, Jin-Quan] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA; [Wisniewski, Steven R.; Eastgate, Martin D.] Bristol Myers Squibb, Chem & Synthet Dev, New Brunswick, NJ 08903 USA; [Chen, Jason S.] Scripps Res Inst, Automated Synth Facil, La Jolla, CA 92037 USA; [Qiao, Jennifer Xiaoxin; Ewing, William R.] Bristol Myers Squibb, Discovery Chem, Princeton, NJ 08543 USA; [Richter, Jeremy M.] Bristol Myers Squibb, Res & Dev, Hopewell, NJ 08534 USA in 2020, Cited 41. Name: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biologically important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing.

Name: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Qian, SQ; Li, ZQ; Li, MY; Wisniewski, SR; Qiao, JX; Richter, JM; Ewing, WR; Eastgate, MD; Chen, JS; Yu, JQ or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Application In Synthesis of Isobenzofuran-1(3H)-one. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation published in 2020, Reprint Addresses Du, JR (corresponding author), Sichuan Univ, Dept Pharmacol, Chengdu, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the underlying mechanisms. Transient middle cerebral artery occlusion (tMCAO) was used as a mouse model of ischemic stroke, while BV2 cells stimulated with conditioned medium collected from oxygen-glucose deprivation-treated HT22 cells were used in in vitro ischemic studies. The current results showed that CD21 dose-dependently and significantly improved neurological outcomes in tMCAO mice. Biochemical analyses revealed that CD21 decreased the expression of M1 phenotype markers (CD86, interleukin-1 beta and inducible nitric oxide synthase) and increased the expression of M2 phenotype markers (CD206, interleukin-10 and YM1/2) in both ischemic brain tissues and BV2 cells. Meanwhile, CD21 decreased the production of proinflammatory cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha), promoted the release of the antiinflammatory cytokine (interleukin-10), and enhanced the phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) in ischemic brain tissue and BV2 cells. Furthermore, the AMPK inhibitor (compound C) reversed these effects of CD21 in BV2 cells. These findings indicate that CD21 alleviates post-ischemic neuroinflammation through induction of microglial M2 polarization that is at least in part medicated by AMPK activation, suggesting that CD21 may be a promising candidate for protecting against ischemic brain injury.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR or concate me.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem