Day: October 21, 2021

An article Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists WOS:000541741100028 published article about P2X(1) ION-CHANNEL; MOUSE MODEL; ATP; ACTIVATION; EXPRESSION; RESPONSES; NF449; INHIBITOR; PHARMACOLOGY; NUCLEOTIDES in [Tian, Maoqun; Abdelrahman, Aliaa; Azazna, Djamil; Spanier, Claudia; Densborn, Sabrina; Hinz, Sonja; Mueller, Christa E.] Univ Bonn, PharmaCtr Bonn, Pharmaceut Inst, Pharmaceut & Med Chem, D-53121 Bonn, Germany; [Baqi, Younis] Sultan Qaboos Univ, Dept Chem, Fac Sci, Muscat 123, Oman; [Fuentes, Eduardo] Univ Talca, Dept Clin Biochem & Immunohaematol, Thrombosis Res Ctr, Med Technol Sch,Fac Hlth Sci,Interdisciplinary Ct, Talca 3460000, Chile; [Schmid, Ralf] Univ Leicester, Dept Mol & Cell Biol, Leicester LE1 7RH, Leics, England; [Schmid, Ralf] Univ Leicester, Leicester Inst Struct & Chem Biol, Leicester LE1 7RH, Leics, England in 2020, Cited 78. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. SDS of cas: 87-41-2

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 mu M) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 mu M), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE or concate me.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity WOS:000469292300026 published article about PROTEIN-PROTEIN INTERACTIONS; BACTERIOFERRITIN STRUCTURE; IRON-METABOLISM; BINDING; ANTIBIOTICS; FERREDOXIN; RESISTANCE; DYNAMICS; PROMOTES; GALLIUM in [Hewage, Achala N. D. Punchi; Eshelman, Kate] Univ Kansas, Dept Chem, 2030 Becker Dr, Lawrence, KS 66047 USA; [Yao, Huili; Rivero, Mario] Louisiana State Univ, Dept Chem, 229A Choppin Hall, Baton Rouge, LA 70803 USA; [Nammalwar, Baskar; Gnanasekaran, Krishna Kumar; Bunce, Richard A.] Oklahoma State Univ, Dept Chem, Stillwater, OK 74078 USA; [Lovell, Scott] Univ Kansas, Prot Struct Lab, 2034 Becker Dr, Lawrence, KS 66047 USA; [Phaniraj, Sahishna M.; Lee, Molly M.; Peterson, Blake R.] Univ Kansas, Dept Med Chem, 2034 Becker Dr, Lawrence, KS 66047 USA; [Battaile, Kevin P.] Hauptman Woodward Med Res Inst, IMCA CAT, 9700 South Cass Ave,Bldg 435A, Argonne, IL 60439 USA; [Reitz, Allen B.] Fox Chase Chem Divers Ctr Inc, 3805 Old Easton Rd, Doylestown, PA 18902 USA; [Nammalwar, Baskar] 10522 Parkdale Ave, San Diego, CA 92126 USA; [Gnanasekaran, Krishna Kumar] 4591 Gatineau Ave, Mississauga, ON L4Z 2R9, Canada; [Eshelman, Kate] 10 Waterview Blvd, Parsippany, NJ 07054 USA; [Lee, Molly M.] NCI, Hatfield CRC, Bldg 10, Bethesda, MD 20892 USA in 2019, Cited 60. COA of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the structure-guided development of small molecule inhibitors of the BfrB-Bfd protein-protein interaction. The process was initiated by screening a fragment library and followed by obtaining the structure of a fragment hit bound to BfrB. The structural insights were used to develop a series of 4-(benzylamino)- and 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively bind BfrB at the Bfd binding site. Challenging P. aeruginosa cells with the 4-substituted isoindoline analogs revealed a dose-dependent growth phenotype. Further investigation determined that the analogs elicit a pyoverdin hyperproduction phenotype that is consistent with blockade of the BfrB-Bfd interaction and ensuing irreversible accumulation of iron in BfrB, with concomitant depletion of iron in the cytosol. The irreversible accumulation of iron in BfrB prompted by the 4-substituted isoindoline analogs was confirmed by visualization of BfrB-iron in P. aeruginosa cell lysates separated on native PAGE gels and stained for iron with Ferene S. Challenging P. aeruginosa cultures with a combination of commercial fluoroquinolone and our isoindoline analogs results in significantly lower cell survival relative to treatment with either antibiotic or analog alone. Collectively, these findings furnish proof of concept for the usefulness of small molecule probes designed to dysregulate bacterial iron homeostasis by targeting a protein-protein interaction pivotal for iron storage in the bacterial cell.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Hewage, ANDP; Yao, HL; Nammalwar, B; Gnanasekaran, KK; Lovell, S; Bunce, RA; Eshelman, K; Phaniraj, SM; Lee, MM; Peterson, BR; Battaile, KP; Reitz, AB; Rivero, M or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

SDS of cas: 87-41-2. In 2020 TOXICOL IN VITRO published article about PEROXIDE-INDUCED DAMAGE; OXIDATIVE STRESS; 3-SUBSTITUTED ISOCOUMARINS; CELLS; CHEMISTRY in [Teixeira, Aniely dos Reis; Ribeiro, Iara Mariana Lellis; Oliveira, Laser Antonio Machado; Nogueira, Katiane de Oliveira Pinto Coelho] Univ Fed Ouro Preto, Dept Biol Sci, Neurobiol & Biomat Lab, Ouro Preto, MG, Brazil; [Teixeira, Robson Ricardo; Pereira, Wagner Luiz] Univ Fed Vicosa, Dept Chem, Vicosa, MG, Brazil; [Manhabosco, Taise Matte; de Brito, Ana Carolina Ferreira] Univ Fed Ouro Preto, Dept Phys, REDEMAT, Ouro Preto, MG, Brazil in 2020, Cited 52. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The isobenzofuran-1(3H)-ones (phthalides) exhibit various biological activities, including antioxidant activity on reactive oxygen species (ROS). An excess of ROS that cannot be naturally contained by cellular enzymatic systems is called redox imbalance, which damage cell membranes, proteins, and DNA, thereby possibly triggering neuronal death in several neurodegenerative diseases. Considering our ongoing efforts to find useful compounds to control redox imbalance, herein we evaluated the antioxidant activity of two phtalides (compounds 3 and 4), using primary cultures of hippocampal neurons. Spectrophotometric assays showed that compound 3 significantly reduced (p <= 0.05) ROS levels and lipid peroxidation compared to the control treatment, while compound 4 was unable at any of the tested concentrations. Despite their structural similarity, these compounds behave differently in the intracellular environment, which was reliably corroborated by the determination of oxidation potentials via cyclic voltammetry. It was demonstrated that compound 3 presents a lower oxidation potential. The combination of the mentioned methods allowed us to find a strong correlation between the chemical structure of compounds and their biological effects. Taking together, the results indicate that compound 3 presents desirable characteristics to act as a candidate pharmacological agent for use in the prevention and treatment of neurodegenerative diseases. SDS of cas: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Teixeira, AD; Teixeira, RR; Ribeiro, IML; Pereira, WL; Manhabosco, TM; de Brito, ACF; Oliveira, LAM; Nogueira, KDPC or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Du, T; Gao, RH; Deng, YF; Wang, C; Zhou, Q; Geng, YH in WILEY-V C H VERLAG GMBH published article about CHANNEL ORGANIC SEMICONDUCTORS; PI-CONJUGATED MATERIALS; HIGH-PERFORMANCE; BUILDING-BLOCK; THIOPHENE-S,S-DIOXIDIZED INDOPHENINE; QUINOIDAL OLIGOTHIOPHENES; SIDE-CHAIN; MOLECULES; POLYMERS; ANALOGS in [Du, Tian; Gao, Ruiheng; Deng, Yunfeng; Wang, Cheng; Zhou, Qian; Geng, Yanhou] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China; [Deng, Yunfeng; Geng, Yanhou] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China; [Deng, Yunfeng; Geng, Yanhou] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China; [Geng, Yanhou] Tianjin Univ, Joint Sch Natl Univ Singapore & Tianjin Univ, Int Campus, Fuzhou 350207, Fujian, Peoples R China in 2020, Cited 46. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A series of 1,3-indandione-terminated pi-conjugated quinoids were synthesized by alkoxide-mediated rearrangement reaction of the respective alkene precursors, followed by air oxidation. This new protocol allows access to quinoidal compounds with variable termini and cores. The resulting quinoids all show LUMO levels below -4.0 eV and molar extinction coefficients above 10(5) L mol(-1) cm(-1). The optoelectronic properties of these compounds can be regulated by tuning the central cores as well as the aryl termini ascribed to the delocalized frontier molecular orbitals over the entire molecular skeleton involving aryl termini. n-Channel organic thin-film transistors with electron mobility of up to 0.38 cm(2) V-1 s(-1) were fabricated, showing the potential of this new class of quinoids as organic semiconductors.

Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Du, T; Gao, RH; Deng, YF; Wang, C; Zhou, Q; Geng, YH or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. In 2020 ORG BIOMOL CHEM published article about AEROBIC OXIDATION; SELECTIVE OXIDATION; ETHERS; COPPER; ISOCOUMARINS; PHTHALIDES; ALKANES in [Thatikonda, Thanusha; Deepake, Siddharth K.; Kumar, Pawan; Das, Utpal] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India; [Deepake, Siddharth K.; Kumar, Pawan; Das, Utpal] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2020, Cited 38. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A metal-free organocatalytic system has been developed for highly efficient benzylic C-H oxygenations of cyclic ethers using oxygen as an oxidant. This oxidation reaction utilizes alpha-angelica lactone as a low cost/low molecular weight catalyst. The optimized reaction conditions allow the synthesis of valued isocoumarins and phthalides from readily available precursors in good yields. Mechanistic studies indicate that the reaction pathway likely involves a radical process via a peroxide intermediate.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Thatikonda, T; Deepake, SK; Kumar, P; Das, U or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about C-H BONDS; CATALYZED BORYLATION; PHOTOINDUCED BORYLATION; ORGANOBORON CHEMISTRY; N-TOSYLHYDRAZONES; ADDITIVE-FREE; ESTERS; EFFICIENT; CARBON; FUNCTIONALIZATION, Saw an article supported by the Canada Research Chair FoundationCanada Research Chairs; Canada Foundation for InnovationCanada Foundation for InnovationCGIAR; FQRNT Center in Green Chemistry and CatalysisFQRNT; Natural Sciences and Engineering Research Council of CanadaNatural Sciences and Engineering Research Council of Canada (NSERC)CGIAR; McGill University. Recommanded Product: Isobenzofuran-1(3H)-one. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Li, JB; Wang, HN; Qiu, ZH; Huang, CY; Li, CJ. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Direct conversion of aldehydes and ketones into alkylboronic esters via deoxygenative borylation represents an unknown yet highly desirable transformation. Herein, we present a one-step and metal-free method for carbonyl deoxy-borylation under mild conditions. A wide range of aromatic aldehydes and ketones are tolerated and successfully converted into the corresponding benzylboronates. By the same deoxygenation manifold with aliphatic aldehydes and ketones, we also enable a concise synthesis of 1,1,2-tris(boronates), a family of compounds that currently lack efficient synthetic methods. Given its simplicity and versatility, we expect that this novel borylation approach could show great promise in organoboron synthesis and inspire more carbonyl deoxygenative transformations in both academic and industrial settings.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Li, JB; Wang, HN; Qiu, ZH; Huang, CY; Li, CJ or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 CHEMOSPHERE published article about POLYCYCLIC AROMATIC-HYDROCARBONS; PHOTOLYSIS HALF-LIVES; SPIRIT OIL-SPILL; CRUDE-OIL; AQUEOUS PHOTODEGRADATION; PHOTOCATALYTIC DEGRADATION; UV-LIGHT; TOXICITY; PAHS; SEDIMENTS in [Kang, Hyun-Joong; Jung, Yerin; Kwon, Jung-Hwan] Korea Univ, Div Environm Sci & Ecol Engn, 145 Anam Ro, Seoul 02841, South Korea in 2019, Cited 65. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Formula: C8H6O2

Crude oil released into the environment contains many polycyclic aromatic hydrocarbons (PAHs). Alkylated PAHs are more abundant than unsubstituted PAHs and their toxicity is also of serious concern. Among the various physical, chemical, and biological weathering processes of crude oils, photodegradation is one of the most important for determining the environmental fate of oil residues. In this study, the photodegradation rate constants of naphthalene and alkylated naphthalenes were determined under simulated laboratory conditions at different temperature. Changes in the luminescence inhibition of Aliivibrio fischeri, as an indicator of the baseline toxicity, were observed in photodegradation mixtures. The major transformation products were also identified by gas chromatography-mass spectrometry. The photodegradation of naphthalene and the eight alkylated naphthalenes was described well by pseudofirst-order kinetics regardless of experimental temperature. The measured toxicity of the reaction mixtures obtained by photodegradative weathering slightly increased initially and then decreased with further weathering. In all cases, the observed toxicity was greater than accounted for by the parent compounds, indicating that the photodegradation products also contributed significantly to the overall toxicity of the mixtures. The identified photodegradation products were mostly oxygenated compounds such as alcohols, aldehydes, ketones, and quinones, which warrant further investigation. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Kang, HJ; Jung, Y; Kwon, JH or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Platinum-on-Carbon-Catalyzed Aqueous Oxidative Lactonization of Diols by Using Molecular Oxygen WOS:000486072800012 published article about AEROBIC OXIDATION; DEHYDROGENATIVE LACTONIZATION; PALLADIUM NANOPARTICLES; ALCOHOLS; EFFICIENT; HYDROXIDE; 1,4-DIOLS; LACTONES; BEARING in [Takakura, Ryoya; Ban, Kazuho; Sajiki, Hironao; Sawama, Yoshinari] Gifu Pharmaceut Univ, Lab Organ Chem, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan in 2019, Cited 49. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Name: Isobenzofuran-1(3H)-one

A lactonization of various diols catalyzed by platinum on carbon (Pt/C) in water under an atmosphere of molecular oxygen was developed. Derivatives of 1,4- 1,5- and 1,6-diols were transformed into the corresponding five-, six-, and seven-membered lactones by the present oxidative lactonization method.

Name: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Takakura, R; Ban, K; Sajiki, H; Sawama, Y or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Antimicrobial drimane – phthalide derivatives from Hypoxylon fendleri BCC32408 WOS:000498290700028 published article about RESAZURIN in [Intaraudom, Chakapong; Bunbamrung, Nantiya; Dramae, Aibrohim; Boonruangprapa, Tanapong; Pittayakhajonwut, Pattama] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathum Thani, Thailand; [Punyain, Wikorn] Naresuan Univ, Fac Sci, Dept Chem, Phitsanulok 65000, Thailand in 2019, Cited 12. Recommanded Product: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P or concate me.. Recommanded Product: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C in [Zhang, Qiaohong; He, Honghao; Wang, Huibin; Chen, Chen] Ningbo Univ, Sch Mat Sci & Chem Engn, 818 Fenghua Rd, Ningbo 315211, Peoples R China; [Zhang, Zhan] China Tobacco Henan Ind Co Ltd, 8 3rd Ave, Zhengzhou 450001, Peoples R China published Efficient catalytic oxidation of methyl aromatic hydrocarbon with N-alkyl pyridinium salts in 2019, Cited 47. Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A series of N-alkyl pyridinium salts were synthesized and employed as metal-free catalyst for the selective oxidation of methyl aromatic hydrocarbon with molecular oxygen. The electronic effect of the substitutes was found to be an important factor for the catalytic performance. With the introduction of electron-donating substitute -N(CH3)(2), the conversion of p-xylene and selectivity of p-toluic acid could be simultaneously increased. 1-Benzyl-4-N,N-dimethylaminopyridinium salt showed the highest catalytic activity, and 95% conversion with 84% of selectivity to p-toluic acid could be obtained for the selective oxidation of p-xylene. Several methyl aromatic hydrocarbons could all be efficiently oxidized with the reported catalyst at the absence of any metal species.

Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem