Synthetic Route of 50551-63-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 50551-63-8, Name is 6-Methoxybenzofuran,introducing its new discovery.
Synthetic models related to methoxalen and menthofuran-cytochrome P450 (CYP) 2A6 interactions. Benzofuran and coumarin derivatives as potent and selective inhibitors of CYP2A6
Human microsomal cytochrome P450 (CYP) 2A6 contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. We prepared a series of benzofuran and coumarin derivatives that have inhibitory effects on the activity of human CYP2A6. The reported compounds methoxalen and menthofuran had potent inhibitory effects on the activity of CYP2A6 with IC50 values of 0.47 muM and 1.27 muM, respectively. Synthetic benzofuran (4-methoxybenzofuran: IC50=2.20 muM) and coumarin (5-methoxycoumarin: IC50=0.13 muM and 6-methoxycoumarin: IC50=0.64 muM) derivatives, which have more selective effects than those of methoxalen and menthofuran, exhibited comparable activities against CYP2A6. These compounds can be used as a lead compounds in the design of CYP2A6 inhibitor drugs to reduce smoking and tobacco-related cancers.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 50551-63-8, and how the biochemistry of the body works.Synthetic Route of 50551-63-8
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1333O – PubChem