Safety of 6-Fluoronicotinonitrile. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Synthesis and herbicidal activity of 2-cyano-3-methylthio-3-(substituted methylamino)acrylates. Author is Gao, Ying; Zou, Xiao-Mao; Yu, Li-Min; Xu, Han; Liu, Bin; Zhu, You-Quan; Hu, Fang-Zhong; Yang, Hua-Zheng.
A series of 3-amino-2-cyano-3-(methylthio)acrylates were synthesized as herbicidal inhibitors of photosystem II electron transport, in order to estimate the effect of fluorine atom, pyridyl group, chirality, and ester chain on activity. The important intermediate 2-fluoro-5-(aminomethyl)pyridine was synthesized with high yield. The bioassay results showed that most of title compounds had high herbicidal activity in postemergence treatment. The introduction of an α-Me into the 3-substituted methylamino could improve the activity notably. The replacement of H by Cl or F group and Ph by pyridyl group showed different effects, and at the same time, the ester chain affected the activity too.
As far as I know, this compound(3939-12-6)Safety of 6-Fluoronicotinonitrile can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem