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NOVEL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Provided are 2-(piperidin-1-yl)pyrimidin-4(3H)-ones or pharmaceutically acceptable salts thereof, each characterized by having a 1,8-diazaspiro[4.5]deca-3-ene, 1-oxa-8-azaspiro[4.5]deca-3-ene, 2,8-diazaspiro[4.5]deca-3-ene, 2-oxa-8-azaspiro[4.5]deca-3-ene, 2,9-diazaspiro[5.5]undeca-3-ene, 1-oxa-9-azaspiro[5.5]undeca-3-ene, 1,9-diazaspiro[5.5]undeca-4-ene, or 3,9-diazaspiro[5.5]undeca-1-ene structure represented by the following general formula (1):

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H4240O – PubChem

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The design and synthesis of orally active short duration spiroindane growth hormone secretagogues

The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally active secretagogues with a short duration of action.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H4243O – PubChem

Awesome Chemistry Experiments For 1552-42-7

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Application of 1552-42-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 1552-42-7, Crystal violet lactone, introducing its new discovery.

Preparation process of phthalide compound

A process for preparing a phthalide compound represented by the formula (1): STR1 wherein R1, R2, R3, R4, R5 and R6 are individually an alkyl group, and R1 and R2, R3 and R4, and R5 and R6 can respectively bond to each other to form a heterocyclic ring together with a nitrogen atom, comprising oxidizing a triphenylmethane compound represented by the formula (2) STR2 wherein R1, R2, R3, R4, R5 and R6 are the same as above, is oxidized in the presence of activated carbon in an aqueous solvent by an oxidizing agent. The process can provide a fast reaction that produces a high purity product with high yield.

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Benzofuran – Wikipedia,
Benzofuran | C8H4141O – PubChem

Properties and Exciting Facts About Thymolphthalein

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Application of 125-20-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Conference Paper, and a compound is mentioned, 125-20-2, Thymolphthalein, introducing its new discovery.

An automatic system for acidity determination based on sequential injection titration and the monosegmented flow approach

An automatic sequential injection system, combining monosegmented flow analysis, sequential injection analysis and sequential injection titration is proposed for acidity determination. The system enables controllable sample dilution and generation of standards of required concentration in a monosegmented sequential injection manner, sequential injection titration of the prepared solutions, data collecting, and handling. It has been tested on spectrophotometric determination of acetic, citric and phosphoric acids with sodium hydroxide used as a titrant and phenolphthalein or thymolphthalein (in the case of phosphoric acid determination) as indicators. Accuracy better than 4.4% (RE) and repeatability better than 2.9% (RSD) have been obtained. It has been applied to the determination of total acidity in vinegars and various soft drinks. The system provides low sample (less than 0.3 mL) consumption. On average, analysis of a sample takes several minutes.

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Benzofuran – Wikipedia,
Benzofuran | C8H4330O – PubChem

Extracurricular laboratory:new discovery of Thymolphthalein

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Adsorption properties of acid dye on amine-terminated dendritic polymer

A series of amine-terminated dendritic polymers (ADPs) were synthesized by stepwise substitution reaction and were used as an adsorbent for removal of acid black dye NT from aqueous solution. Comparison experiments showed that the ADP-3 has good adsorption effect. Then, the effects of various parameters such as initial acid black dye NT concentration (50-300mg/L) and solution pH(1.5- 6.5) were investigated. The point of zero charge (PZC) of ADP-3 has been determined. Specific surface area and average adsorption pore size of the ADP-3 were 21.378m2/g and 3.833nm, respectively. Field scanning electron microscopy (FESEM) indicated that the adsorption material has porous structure, which provided favorable conditions for adsorption process. The experimental data were analyzed by Langmuir and Freundlich models of adsorption. Equilibrium data were fitted well with the Freundlich model. Thermodynamics parameters, DeltaG, DeltaH and DeltaS indicate that the adsorption of acid black dye NT onto ADPs were spontaneous and endothermic process in nature. Pseudo-first-order and pseudo-second-order kinetic models were used to fit the adsorption kinetic data. The adsorption kinetics was found to follow the pseudo-first-order kinetic model. Amino blocking indicated that the amino content plays an important role in the adsorption process. The adsorbent was also applied to the treatment of leather dye effluent, the results showed that ADP-3 exhibit a prominent adsorption property on leather dye effluent.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H4399O – PubChem

Final Thoughts on Chemistry for Thymolphthalein

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Developments in the chemistry and applications of phthalein dyes. Part 1: industrial applications

This review describes the huge impact of phthalein dyes on multiple industries. Although phthalein dyes demonstrate several vital applications, there appears to be no review in the literature. Part 1 of this review focuses on developments in the chemistry and industrial applications of phthalein dyes. The industrial applications of phthalein dyes are grouped into building/construction applications, coating applications, electronic/electrical applications and miscellaneous applications. The importance of these dyes in various commercial products is also revealed, and patent analysis is provided in the appendix. The uses of phthalein dyes in various fields are important but their growing popularity with fascinating colour change features is particularly notable. Part 2 of the review will focus on the developments in the chemistry and biological applications of phthalein dyes.

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Benzofuran – Wikipedia,
Benzofuran | C8H4379O – PubChem

New explortion of Thymolphthalein

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A specific fluorescent probe for zinc ion based on thymolphthalein and it’s application in living cells

Many diseases are connected with chemical substances, zinc ion is most important ion in chemical substances, because zinc ion (Zn2+) has been shown extensively involved in various physiological and pathological processes. In this work, thymolphthalein with good biocompatibility was introduced, the probe was constructed with interweaved benzimidazole and phenol from into the fluorophore system, hydroxyl and amino creating a multipoint binding pocket, which zinc can coordinate in a cooperative breaking Excited-State Intramolecular Proton Transfer, ESIPT. The fluorescence of this probe adding Zn2+ showed an obvious ?turn on? in a quick response within 5 s. In addition, the probe had a good selectivity for zinc ion over other analytes. Furthermore, we also studied the fluorescence imaging of probe in the presence of Zn2+ in living A549 cells.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H4311O – PubChem

Some scientific research about 1552-42-7

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Application of 1552-42-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1552-42-7, Name is Crystal violet lactone, molecular formula is C26H29N3O2. In a Article£¬once mentioned of 1552-42-7

Composite phase change materials with good reversible thermochromic ability in delignified wood substrate for thermal energy storage

Phase change materials applied in the thermal insulation of building or storage system are beneficial to slow down internal temperature fluctuation and decrease energy consumption. Visible temperature change can provide convenience for people’s production and life. In this work, the thermochromic delignified wood composite phase change materials (TCDWs) composed of thermochromic (TC) compound and delignified wood (DW) are fabricated by vacuum-assisted impregnation method. Various techniques are applied to characterize mechanical and thermal properties of TCDWs. Results indicate that TCDWs exhibit suitable phase change temperature, large latent heat, good thermal reliability, as well as excellent thermal stability and mechanical properties. More importantly, TCDWs have excellent reversible thermochromic ability and visibly show the phase change progress and temperature by color change from dark blue to off-white. The thermal insulation ability of TCDWs can reduce heat flow and heat exchange between inside and outside environment, maintaining the internal temperature for longer time. The largest absorption capacity of DW is 65%, which is 15% more than that of pristine wood (PW). The excellent reversible thermochromic, thermal and mechanical properties of TCDWs have great potential in thermal energy storage applications including thermal insulation, decoration, furniture, storage and building energy conservation.

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Benzofuran – Wikipedia,
Benzofuran | C8H4215O – PubChem

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Solution properties of dissymmetric sulfonate-type anionic gemini surfactants

Dissymmetric and symmetric anionic gemini surfactants, N-alkyl-N?-alkyl-N,N?dipropanesulfonylethylenediamine (CmCnSul, where m and n represent alkyl chain lengths of m-n = 4-16, 6-14, 8-12, 10-10, and 12-12), were synthesized by two- or three-step reactions. Their physicochemical properties were characterized by equilibrium surface tension measurements, steady-state fluorescence spectroscopy of pyrene, and dynamic light scattering. The critical micelle concentration (CMC) of the dissymmetric surfactants C4C16Sul, C6C14Sul, and C8C12Sul was slightly lower than that of the symmetric surfactant C10C10Sul. The occupied area per molecule (A) of C8C12Sul was smaller than that of C10C10Sul, indicating that C8C12Sul has a high surface activity. However, the increase in the degree of dissymmetry from C8C12Sul to C6C14Sul and then to C4C16Sul resulted in high surface tension and large A. Based on the surface tension, the standard free energies of micellization (?Gmic) and adsorption (?Gads), the efficiency of surface adsorption (pC20), and the effectiveness of surface adsorption (CMC/C20) were obtained. These parameters suggested that C8C12Sul formed micelles more readily than the other surfactants. The properties determined from the surface tension indicated that C8C12Sul?s ability is intermediate between those of C10C10Sul and C12C12Sul. The pyrene fluorescence and dynamic light scattering results revealed that the micelle size depends on the longer of the two alkyl chains in dissymmetric surfactants.

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Benzofuran – Wikipedia,
Benzofuran | C8H4425O – PubChem

Awesome Chemistry Experiments For Crystal violet lactone

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Synthetic Route of 1552-42-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1552-42-7, Name is Crystal violet lactone, molecular formula is C26H29N3O2. In a Article£¬once mentioned of 1552-42-7

The inhibition of triphenylmethane primary dye fading in carbonless copying paper systems by singlet oxygen quenching bis(dithiocarbamato)nickel(II) complexes

Several of the dyes used in commercial carbonless copying systems act as singlet oxygen sensitisers, the production of which causes fading of the dyes [1]. A series of bis-(dithiocarbamato)nickel(II) complexes were synthesised and shown to be efficient singlet oxygen quenchers in solution in the presence of the acid activated clay. On the dry clay, however, only the hydroxyl-containing complexes were effective as they bound more efficiently to the clay. Fading was retarded more efficiently with fluoran TPM dyes, which produce more singlet oxygen, than phthalide TPM dyes. In some cases, the position and intensity of the lambdamax of the dyes was preserved efficiently.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H4156O – PubChem